Synonyms
Definition
Phosphatases are enzymes which catalyze the cleavage of monophosphate ester bonds from the phosphorylated form of different kinds of substrates. Their activity in dephosphorylating substrates is opposite to those of kinases, which are responsible for phosphorylation processes. Protein phosphorylation is the most common and the best-studied posttranslational modification. It has been estimated that about 30 % of all proteins can be regulated by phosphorylation. The reversible phosphorylation of proteins represents a ubiquitous regulatory mechanism for diverse pathways and systems in eukaryotic cells.
Introduction
Two decades ago, phosphorylation signaling pathway, known to be controlled by kinases, has been suggested to be involved in Plasmodiumparasite development/growth. In these first reports, the use of inhibitors for kinases on cultured parasites showed an arrest of their development and a drastic inhibition of their capacity to...
References
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Khalife, J., Fréville, A., Vandomme, A., Pierrot, C. (2013). Phosphatases. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_59-1
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DOI: https://doi.org/10.1007/978-1-4614-8757-9_59-1
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