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Core Concepts and Treatment of Metabolic Acidosis

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Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance

Abstract

Acid–base homeostasis constitutes one of the most fundamental biologic processes vital to survival of all life-forms. Derangements acid–base balance can result from a variety of causes and can exert multiple effects on many organs. Metabolic acidosis is a state of excess accumulation of acid in the body due to excess production, reduced excretion, or a combination of both. In this chapter, we summarize some basic acid–base chemistry and biology for the clinician, highlights how to utilize simple laboratory findings to approach metabolic acidosis, and finally discuss the evidence that supports the various treatment protocols and controversies in metabolic acidosis.

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Acknowledgments

The authors are grateful to Ms. Vicki Perkins for her expert assistance in the preparation of the chapter. The authors are supported by the National Institutes of Health, The National Kidney Foundation, the Charles and Jane Pak Foundation, and the Simmons Family Foundation.

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  1. Department of Nephrology, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX, 75246, USA

    Michael R. Wiederkehr M.D.

  2. Center for Mineral Metabolism and Clinical Research, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-8885, USA

    Orson W. Moe M.D.

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Correspondence to Orson W. Moe M.D. .

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  1. Brigham and Women's Hospital, Harvard Medical School, VA Boston Healthcare System, Blackfan Circle 4, Boston, 02115, Massachusetts, USA

    David B. Mount

  2. Harvard Medical School, Renal Division, Brigham and Women's Hospital, Francis Street 75, Boston, 02115, Massachusetts, USA

    Mohamed H. Sayegh

  3. Harvard Medical School, Renal Division, Brigham and Women's Hospital, Francis Street 75, Boston, 02115, Massachusetts, USA

    Ajay K. Singh

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Wiederkehr, M.R., Moe, O.W. (2013). Core Concepts and Treatment of Metabolic Acidosis. In: Mount, D., Sayegh, M., Singh, A. (eds) Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-3770-3_8

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