Abstract
Human studies have resulted in extensive and many times conflicting reports of alterations in plasma and platelet monoamine oxidase (MAO) activity, Vmax and Km in a variety of disease states (1,2). A partial list of these conditions include affective bipolar disorders, schizophrenia, essential hypertension, iron deficiency anemia, specific developmental dislexia, migraine headache and insulin-dependent (Type I) diabetes (2). Kinetic parameters of this enzyme also appear to be significantly modified by a number of drug treatments (3).
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Zeller E. A., Boshes B., Arbit J., Bieber M., Blonsky E. R., Dolkart M., and Huprikar S. V. (1976) Molecular biology of neurological and psychiatric disorders. 1. Effects of Parkinsonism, age, sex and L-DOPA on platelet monoamine oxidase. J. Neural Transmission 39, 63–77.
Mosnaim A. D., Wolf M. E., Huprikar S., Singh S. P., and Zeller E. A. (1979) Reduced monoamine oxidase activity in blood platelets from insulin-dependent diabetics. Diabetes 28, 455–456.
Friedhoff A. J., Miller J. C., and Weisenfreund J. (1978) Human platelet MAO in drug-free and medicated schizophrenic patients. Amer. J. Psychiat. 135, 952–955.
Kimball C. P. (1971) Emotional and psychosocial aspects of diabetes mellitus. Med. Clin. North Am. 55, 1007–1018.
Mosnaim A. D. and Wolf M. E. (eds.) (1978) Non-catecholic Phenylethylamines, Part 1: Phenylethylamine: Biological Mechanisms and Clinical Aspects. Marcel Dekker, New York.
Mosnaim A. D. and Wolf M. E. (eds.) (1980) Non-catecholic Phenylethylamines, Part 2: Phenylethanolamine, Tyramines and Octopamine. Marcel Dekker, New York.
Feldman J. and Lebovitz H. J. (1971) The nature of the interaction of amines with the pancreatic beta cell to influence insulin secretion. J. Pharmacol. Exp.Ther. 179, 56–65.
Sandler M. (1977) Transitory platelet monoamine oxidase deficit in migraine: Some reflections. Headache 17, 153–158.
Diamond S. and Medina J. L. (1980) Review article: Current thoughts on migraine. Headache 20, 208–212.
Mosnaim A. D., Karoum F., Zeller A., Callaghan O. H., Singh S. P., and Wolf M. E. (1982) Platelet monoamine oxidase activity and plasma levels of non- catecholic phenylethylamines in insulin-dependent diabetic subjects. Clin. Chim. Acta 126, 237–242.
Tryding N., Nilsson S. E., Tufvesson G., Berg R., Carlstrom S., Elmfors B., and Nilsson J. E. (1969) Physiological and pathological influences on serum monoamine oxidase level: Effect of age, sex, contraceptive steroids and diabetes mellitus. Scand. J. Clin. Lab. Invest. 23, 79–84.
Billett E., Hanley S., Heptinstall S., and Mayer R. J. (1983) Monoamine oxidase activity in diabetes. Diabetes 32, 130–133.
Mayanil C. S. K., Kazmi S. M. I., and Baquer N. Z. (1982) Changes in monoamine oxidase activity in rat brain during alloxan diabetes. J. Neurochem. 38, 179–183.
Wolf M. E. and Mosnaim A. D. (1983) Phenylethylamine in neuropsychiatrie disorders. Gen. Pharmacol. 14, 385–390.
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© 1984 The Humana Press Inc.
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Mosnaim, A.D., Wolf, M.E., Diamond, S. (1984). Noncatecholic Phenylethylamines and MAO Activity in Diabetes and Migraine. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_47
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DOI: https://doi.org/10.1007/978-1-4612-5312-9_47
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