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Noncatecholic Phenylethylamines and MAO Activity in Diabetes and Migraine

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Neurobiology of the Trace Amines
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Abstract

Human studies have resulted in extensive and many times conflicting reports of alterations in plasma and platelet monoamine oxidase (MAO) activity, Vmax and Km in a variety of disease states (1,2). A partial list of these conditions include affective bipolar disorders, schizophrenia, essential hypertension, iron deficiency anemia, specific developmental dislexia, migraine headache and insulin-dependent (Type I) diabetes (2). Kinetic parameters of this enzyme also appear to be significantly modified by a number of drug treatments (3).

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References

  1. Zeller E. A., Boshes B., Arbit J., Bieber M., Blonsky E. R., Dolkart M., and Huprikar S. V. (1976) Molecular biology of neurological and psychiatric disorders. 1. Effects of Parkinsonism, age, sex and L-DOPA on platelet monoamine oxidase. J. Neural Transmission 39, 63–77.

    Article  CAS  Google Scholar 

  2. Mosnaim A. D., Wolf M. E., Huprikar S., Singh S. P., and Zeller E. A. (1979) Reduced monoamine oxidase activity in blood platelets from insulin-dependent diabetics. Diabetes 28, 455–456.

    Article  PubMed  CAS  Google Scholar 

  3. Friedhoff A. J., Miller J. C., and Weisenfreund J. (1978) Human platelet MAO in drug-free and medicated schizophrenic patients. Amer. J. Psychiat. 135, 952–955.

    PubMed  CAS  Google Scholar 

  4. Kimball C. P. (1971) Emotional and psychosocial aspects of diabetes mellitus. Med. Clin. North Am. 55, 1007–1018.

    PubMed  CAS  Google Scholar 

  5. Mosnaim A. D. and Wolf M. E. (eds.) (1978) Non-catecholic Phenylethylamines, Part 1: Phenylethylamine: Biological Mechanisms and Clinical Aspects. Marcel Dekker, New York.

    Google Scholar 

  6. Mosnaim A. D. and Wolf M. E. (eds.) (1980) Non-catecholic Phenylethylamines, Part 2: Phenylethanolamine, Tyramines and Octopamine. Marcel Dekker, New York.

    Google Scholar 

  7. Feldman J. and Lebovitz H. J. (1971) The nature of the interaction of amines with the pancreatic beta cell to influence insulin secretion. J. Pharmacol. Exp.Ther. 179, 56–65.

    PubMed  CAS  Google Scholar 

  8. Sandler M. (1977) Transitory platelet monoamine oxidase deficit in migraine: Some reflections. Headache 17, 153–158.

    Article  PubMed  CAS  Google Scholar 

  9. Diamond S. and Medina J. L. (1980) Review article: Current thoughts on migraine. Headache 20, 208–212.

    Article  PubMed  CAS  Google Scholar 

  10. Mosnaim A. D., Karoum F., Zeller A., Callaghan O. H., Singh S. P., and Wolf M. E. (1982) Platelet monoamine oxidase activity and plasma levels of non- catecholic phenylethylamines in insulin-dependent diabetic subjects. Clin. Chim. Acta 126, 237–242.

    Article  PubMed  CAS  Google Scholar 

  11. Tryding N., Nilsson S. E., Tufvesson G., Berg R., Carlstrom S., Elmfors B., and Nilsson J. E. (1969) Physiological and pathological influences on serum monoamine oxidase level: Effect of age, sex, contraceptive steroids and diabetes mellitus. Scand. J. Clin. Lab. Invest. 23, 79–84.

    Article  PubMed  CAS  Google Scholar 

  12. Billett E., Hanley S., Heptinstall S., and Mayer R. J. (1983) Monoamine oxidase activity in diabetes. Diabetes 32, 130–133.

    Article  PubMed  CAS  Google Scholar 

  13. Mayanil C. S. K., Kazmi S. M. I., and Baquer N. Z. (1982) Changes in monoamine oxidase activity in rat brain during alloxan diabetes. J. Neurochem. 38, 179–183.

    Article  PubMed  CAS  Google Scholar 

  14. Wolf M. E. and Mosnaim A. D. (1983) Phenylethylamine in neuropsychiatrie disorders. Gen. Pharmacol. 14, 385–390.

    PubMed  CAS  Google Scholar 

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© 1984 The Humana Press Inc.

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Mosnaim, A.D., Wolf, M.E., Diamond, S. (1984). Noncatecholic Phenylethylamines and MAO Activity in Diabetes and Migraine. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_47

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  • DOI: https://doi.org/10.1007/978-1-4612-5312-9_47

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9781-9

  • Online ISBN: 978-1-4612-5312-9

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