Abstract
The endothelial lining of blood vessels comprises a pivotal interface between flowing blood and vessel wall, performing a variety of specific functions to maintain normal functioning of vessel wall and normal blood flow. It is widely accepted now that injury of vascular endothelium may be the initial step in development of some pathologies, i.e., thrombosis, atherosclerosis, etc. Studies have indicated that endothelial functions are closely related to morphological organization of endothelial monolayer, the latter reflecting changes in circulatory system and vessel wall.
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References
Langille BL, Adamson SL (1981) Relationship between blood flow direction and endothelial cell orientation at arterial branch sites in rabbit and mice. Circ Res 48:481–485.
Levesque MJ, Liepsch D, Moravec S, Nerem RM (1986) Correlation in endothelial cell shape and wall sheer stress in a stenosed dog aorta. Arteriosclerosis 6:220–229.
De Chastonay C, Gabbiani G, Elemer G, Huttner I (1983) Remodeling of the rat aortic endothelial layer during experimental hypertensia: Changes in replication rate, cell density, and surface morphology. Lab Invest 48:45-52.
Shepro D, Welles SL, Hecjtman HB (1984) Vasoactive agonists prevent erythrocyte extravasation in thrombocytopenic hamsters. Thromb Res 45:421–427.
Welles SL, Shepro D, Heichtman HB (1985) Vasoactive amines modulate actin calbes (stress fibres) and surface area in cultured bovine endothelium. J Cell Physiol 123:337–342.
Sandra A, Bar RS, Dolash S, Marshall SJ, Kaduce TL, Spector AA (1985) Morphological alterations in cultured endothelial cells induced by arachidonic acid. Exp Cell Res 158:484–492.
Galdal KS, Evensen SA, Brosstad F (1981) Effects of divalent cations and various vasoactive and haemostatically active agents on the integrity of monolayers of cultured human endothelial cells. Thromb Res 21:273–284.
Galdal KS, Evensen SA, Nilsen E (1983) Thrombin-induded shape changes of cultured endothelial cells: Metabolic and functional observations. Thromb Res 32:57–66.
Nabika T, Nara Y, Yamori Y, Lovenberg W, Endo J (1985) Angiotensin II and phorbol ester enhance isoproterenol- and vasoactive intestinal peptide (VIP) — induced cyclic AMP accumulation in vascular smooth muscle cells. Biochem Biophys Res Communs 131:30–36.
Vanecek I, Sugden D, Weller J, Klein D (1985) Atypical synergistic alpha1- and beta-adrenergic regulation of adenosine 3′,5′ -monophosphate and guanosine 3′,5′-monophosphate in rat pinealocytes. Endocrinology 116:2167–2173.
Sibley DR, Jeffs RA, Daniel K, Nambi P, Lefkowitz RJ (1986) Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes. Arch Biochem Biophys 244:373–381.
Reidy MA (1985) Biology of disease. A reassessment of endothelial injury and arterial lesion formation. Lab Invest 53:513–520.
Christensen BC (1974) Repair of arterial tissue. A scanning electron microscopic (SEM) and light microscopic study on the endothelium of rabbit thoracic aorta following noradrenaline in toxic doses. Virchows Arch [A] 363:33–38.
Repin VS, Dolgov W, Zaikina OE, Novikov ID, Antonov AS, Nikolaeva MA, Smirnov VN (1984) Heterogeneity of endothelium in human aorta — A quantitative analysis by scanning electron microscopy. Atherosclerosis 50:35–52.
Zimmerman M, McGeachie J (1986) Quantitation of the relationship between aortic endothelial intercellular morphology and peameability to albumin. Atherosclerosis 59:277–282.
Antonov AS, Nikolaeva MA, Klueva TS, Romanov YuA, Babaev VR, Bystrevskaya VB, Perov NA, Repis VS, Smirnov VN (1986) Primary culture of endothelial cells from atherosclerotic human aorta. Part I. Identification, morphological and ultrastructural characteristics of two endothelial cell subpopulations. Atherosclerosis 59:1–19.
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Smirnov, V.N., Antonov, A.S., Lukashev, M.E., Romanov, Y.A., Cornhill, J.F., Gerrity, R.G. (1990). Second Messengers in Human Vascular Endothelial Cells: Regulation of Endothelial Monolayer Formation and Repair. In: Glagov, S., Newman, W.P., Schaffer, S.A. (eds) Pathobiology of the Human Atherosclerotic Plaque. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3326-8_3
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DOI: https://doi.org/10.1007/978-1-4612-3326-8_3
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