Definition
Lymphocyte population dynamics is the time evolution process in lymphocyte population composition. Lymphocytes are the main actors of the “adaptive” immunity and are characterized by various cell subpopulations that differentiate in so-called “central” compartments, the bone marrow for B cells and the thymus for T cells. This differentiation process involves high proliferation and somatic gene rearrangements in lymphocyte precursors resulting in high diversity of antigen specific receptors, namely B cell receptors (BCR) and T cell receptors (TCR). This differentiation process generates the collection of antigen receptor defining the “immune repertoire.” After a stringent selection process characterized by high cell death, mature T and B cells are able to react to antigenic stimulation in...
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References
Asquith B, Borghans JA et al (2009) Lymphocyte kinetics in health and disease. Trends Immunol 30(4):182–189
Freitas A, Rocha B (1993) Lymphocyte lifespans: homeostasis, selection and competition. Immunol Today 14:25
Freitas AA, Rocha B et al (1986) Lymphocyte population kinetics in the mouse. Immunol Rev 91:5
Kedzierska K, La Gruta NL et al (2008) Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Mol Immunol 45(3):607–618
Miqueu P, Guillet M et al (2007) Statistical analysis of CDR3 length distributions for the assessment of T and B cell repertoire biases. Mol Immunol 44(6):1057–1064
Murphy, Travers P, Walport M (2008) Janeway’s immunobiology, 7th edn. Garland Science, New York
Zuniga-Pflucker JC, van den Brink MR (2007) Giving T cells a chance to come back. Semin Immunol 19(5):279
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Thomas-Vaslin, V., Six, A., Bellier, B., Klatzmann, D. (2013). Lymphocyte Dynamics and Repertoires, Biological Methods. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_95
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_95
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