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5-Hydroxytryptamine Receptor 2C

  • Reference work entry
Encyclopedia of Signaling Molecules

  • 229 Accesses

Synonyms

5-HT2C; 5-HT1C

Historical Background

The 5-hydroxytryptamine type 2C receptor (5-HT2C, previously 5-HT1C) is one of the 13 G protein-coupled receptor subtypes activated by serotonin. 5-HT2C receptors are involved in a large variety of physiological functions such as nociception, motor behavior, endocrine secretion, thermoregulation, modulation of appetite, and the control of exchanges between the central nervous system and the cerebrospinal fluid. They have also been implicated in numerous pathologies such as schizophrenia, anxiety, depression, Parkinson’s disease, drug addiction, and obesity (Berg et al. 2008). In line with their implication in various pathological situations, 5-HT2C receptors are considered as a major pharmacological target for the development of new treatments.

With regard to signaling, 5-HT2C receptors are positively coupled to phospholipase Cß protein via Gαq in several brain regions (Berg et al. 2008). Native 5-HT2C receptors also activate phospholipase...

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Authors and Affiliations

  1. Dépt. de Neurobiologie, Institut de Génomique Fonctionnelle, Unité Mixte de Recherche 5203, Centre National de la Recherche Scientifique, Institut National de Santé et de la Recherche Médicale U661, Universités Montpellier 1 and 2, F-34094, Montpellier Cedex 5, France

    Dr. Carine Becamel, Dr. Philippe Marin & Dr. Joël Bockaert

Authors
  1. Dr. Carine Becamel
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  2. Dr. Philippe Marin
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  3. Dr. Joël Bockaert
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Corresponding author

Correspondence to Carine Becamel .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Becamel, C., Marin, P., Bockaert, J. (2012). 5-Hydroxytryptamine Receptor 2C. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_55

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