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Influenza A Viruses in Peridomestic Mammals

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Animal Influenza Virus

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2123))

Abstract

During recent years, serological evidence has shown that a number of peridomestic mammals (e.g., those commonly found in or around human structures) are naturally exposed to influenza A viruses (IAVs). In addition, experimental studies have demonstrated that many of these species can successfully replicate several different IAVs, including IAVs of high consequence to public or agricultural health. The replication of some IAVs within this group of mammals could have implications for biosecurity associated with poultry production and live bird markets in some regions of the world. Given this evidence, the need for further study and understanding of the role that peridomestic mammals may play in IAV dynamics is increasingly being recognized. This chapter will provide a general overview on IAV associations in peridomestic mammals, especially as they pertain to avian IAVs, and provide some general views and guidelines for sampling these species in various situations.

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References

  1. Romero Tejeda A, Aiello R, Salomoni A, Berton V, Vascellari M, Cattoli G (2015) Susceptibility to and transmission of H5N1 and H7N1 highly pathogenic avian influenza viruses in bank voles (Myodes glareolus). Vet Res 46:51

    Article  Google Scholar 

  2. Horimoto T, Maeda K, Murakami S, Kiso M, Iwatsuki-Horimoto K, Sashika M, Ito T, Suzuki K, Yokoyama M, Kawaoka Y (2011) Highly pathogenic avian influenza virus infection in feral raccoons, Japan. Emerg Infect Dis 17:714–717

    Article  Google Scholar 

  3. Mori E, Mazza G, Menchetti M, Panzeri M, Gager Y, Bertolino S, Di Febbraro M (2015) The masked invader strikes again: The conquest of Italy by the Northern raccoon. Hystrix 26:1–5

    Google Scholar 

  4. Hassell JM, Begon M, Ward MJ, Fèvre EM (2017) Urbanization and Disease Emergence: Dynamics at the Wildlife–Livestock–Human Interface. Trends Ecol Evol 32:55–67

    Article  Google Scholar 

  5. Brown C (2013) Spillover: Animal infection and the next human pandemic. Emerg Infect Dis 19:349

    Article  Google Scholar 

  6. Hall JS, Bentler KT, Landolt G, Elmore SA, Minnis RB, Campbell TA, Barras SC, Root JJ, Pilon J, Pabilonia K, Driscoll C, Slate D, Sullivan H, McLean RG (2008) Influenza infection in wild raccoons. Emerg Infect Dis 14:1842–1848

    Article  Google Scholar 

  7. Root JJ, Shriner SA, Bentler KT, Gidlewski T, Mooers NL, Ellis JW, Spraker TR, VanDalen KK, Sullivan HJ, Franklin AB (2014) Extended viral shedding of a low pathogenic avian influenza virus by striped skunks (Mephitis mephitis). PLoS One 9:e70639

    Article  Google Scholar 

  8. Root JJ, Shriner SA, Bentler KT, Gidlewski T, Mooers NL, Spraker TR, VanDalen KK, Sullivan HJ, Franklin AB (2014) Shedding of a low pathogenic avian influenza virus in a common synanthropic mammal - the cottontail rabbit. PLoS One 9:e103513

    Article  Google Scholar 

  9. Zhou J, Sun W, Wang J, Guo J, Yin W, Wu N, Li L, Yan Y, Liao M, Huang Y, Luo K, Jiang X, Chen H (2009) Characterization of the H5N1 highly pathogenic avian influenza virus derived from wild pikas in China. J Virol 83:8957–8964

    Article  CAS  Google Scholar 

  10. Shriner SA, VanDalen KK, Mooers NL, Ellis JW, Sullivan HJ, Root JJ, Franklin AB (2012) Low-pathogenic avian influenza viruses in wild house mice. PLoS One 7:e39206

    Article  CAS  Google Scholar 

  11. Yamaguchi E, Fujii K, Ogawa H, Imai K (2018) First detection of influenza A virus genes from wild raccoons in Japan. Virus Genes 54:591–595

    Article  CAS  Google Scholar 

  12. Caron A, Cappelle J, Cumming GS, de Garine-Wichatitsky M, Gaidet N (2015) Bridge hosts, a missing link for disease ecology in multi-host systems. Vet Res 46:83

    Article  Google Scholar 

  13. Kaplan BS, Russier M, Jeevan T, Marathe B, Govorkova EA, Russell CJ, Kim-Torchetti M, Choi YK, Brown I, Saito T, Stallknecht DE, Krauss S, Webby RJ (2016) Novel highly pathogenic avian A(H5N2) and A(H5N8) influenza viruses of clade 2.3.4.4 from North America have limited capacity for replication and transmission in mammals. mSphere 1:e00003–e00016

    Article  CAS  Google Scholar 

  14. Root JJ, Bosco AM, Marlenee NL, Bowen RA (2018) Cottontail rabbits shed clade 2.3.4.4 H5 highly pathogenic avian influenza A viruses. Arch Virol 163:2823–2827

    Article  CAS  Google Scholar 

  15. Root JJ, Shriner SA, Ellis JW, VanDalen KK, Sullivan HJ (2017) Low viral doses are sufficient to infect cottontail rabbits with avian influenza A virus. Arch Virol 162:3381–3388

    Article  CAS  Google Scholar 

  16. Achenbach JE, Bowen RA (2011) Transmission of avian influenza A viruses among species in an artificial barnyard. PLoS One 6:e17643

    Article  CAS  Google Scholar 

  17. Cummings CO, Hill NJ, Puryear WB, Rogers B, Mukherjee J, Rosenbaum MH, Rustlander JA (2019) Evidence of influenza A in wild Norway rats (Rattus norvegicus) in Boston, Massachusetts. Front Ecol Evol 7:36

    Google Scholar 

  18. Runstadler JA, Happ GM, Slemons RD, Sheng ZM, Gundlach N, Petrula M, Senne D, Nolting J, Evers DL, Modrell A, Huson H, Hills S, Rothe T, Marr T, Taubenberger JK (2007) Using RRT-PCR analysis and virus isolation to determine the prevalence of avian influenza virus infections in ducks at Minto Flats State Game Refuge, Alaska, during August 2005. Arch Virol 152:1901–1910

    Article  CAS  Google Scholar 

  19. Spackman E, Senne DA, Bulaga LL, Myers TJ, Perdue ML, Garber LP, Lohman K, Daum LT, Suarez DL (2003) Development of real-time RT-PCR for the detection of avian influenza virus. Avian Dis 47:1079–1082

    Article  CAS  Google Scholar 

  20. Root JJ, Bentler KT, Shriner SA, Mooers NL, VanDalen KK, Sullivan HJ, Franklin AB (2014) Ecological routes of avian influenza virus transmission to a common mesopredator: an experimental evaluation of alternatives. PLoS One 9:e102964

    Article  Google Scholar 

  21. Su S, Xing G, Wang J, Li Z, Gu J, Yan L, Lei J, Ji S, Hu B, Gray GC, Yan Y, Zhou J (2016) Characterization of H7N2 avian influenza virus in wild birds and pikas in Qinghai-Tibet Plateau area. Sci Rep 6:30974

    Article  CAS  Google Scholar 

  22. Root JJ, Bosco-Lauth AM, Bielefeldt-Ohmann H, Bowen RA (2016) Experimental infection of peridomestic mammals with emergent H7N9 (A/Anhui/1/2013) influenza A virus: implications for biosecurity and wet markets. Virology 487:242–248

    Article  CAS  Google Scholar 

  23. VanDalen KK, Nemeth NM, Thomas NO, Barrett NL, Ellis JW, Franklin AB, Shriner SA (2019) Experimental infections of Norway rats with avian-derived low pathogenic influenza A viruses. Arch Virol 164:1831–1836

    Google Scholar 

  24. Qi X, Li X, Rider P, Fan W, Gu H, Xu L, Yang Y, Lu S, Wang H, Liu F (2009) Molecular characterization of highly pathogenic H5N1 avian influenza A viruses isolated from raccoon dogs in China. PLoS One 4:e4682

    Article  Google Scholar 

  25. Ciacci-Zanella JR, Vincent AL, Prickett JR, Zimmerman SM, Zimmerman JJ (2010) Detection of anti-influenza A nucleoprotein antibodies in pigs using a commercial influenza epitope-blocking enzyme-linked immunosorbent assay developed for avian species. J Vet Diagn Invest 22:3–9

    Article  Google Scholar 

  26. Van Hemert C, Spivey TJ, Uher-Koch BD, Atwood TC, Sinnett DR, Meixell BW, Hupp JW, Jiang K, Adamas LG, Gustine DD, Ramey AM, Wan XF (2019) Survey of arctic Alaskan wildlife for influenza A antibodies: limited evidence for exposure of mammals. J Wildl Dis 55:387–398

    Article  Google Scholar 

  27. Sullivan HJ, Blitvich BJ, VanDalen K, Bentler KT, Franklin AB, Root JJ (2009) Evaluation of an epitope-blocking enzyme-linked immunosorbent assay for the detection of antibodies to influenza A virus in domestic and wild avian and mammalian species. J Virol Methods 161:141–146

    Article  CAS  Google Scholar 

  28. Roberts NM, Henzler DJ, Clark L (2009) Serologic evidence of avian influenza (H4N6) exposure in a wild-caught raccoon. Avian Dis 53:455–457

    Article  Google Scholar 

  29. Cwach KT, Sandbulte HR, Klonoski JM, Huber VC (2012) Contribution of murine innate serum inhibitors toward interference within influenza virus immune assays. Influenza Other Respir Viruses 6:127–135

    Article  CAS  Google Scholar 

  30. Yamaguchi E, Sashika M, Fujii K, Kobayashi K, Bui VN, Ogawa H, Imai K (2014) Prevalence of multiple subtypes of influenza A virus in Japanese wild raccoons. Virus Res 189:8–13

    Article  CAS  Google Scholar 

  31. Yu Z, Cheng K, Sun W, Xin Y, Cai J, Ma R, Zhao Q, Li L, Huang J, Sang X, Li X, Zhang K, Wang T, Qin C, Qian J, Gao Y, Xia X (2014) Lowly pathogenic avian influenza (H9N2) infection in plateau pika (Ochotona curzoniae), Qinghai Lake, China. Vet Microbiol 173:132–135

    Article  Google Scholar 

  32. Segovia KM, França MS, Bahnson CS, Latorre-Margalef N, Stallknecht DE (2018) Are microneutralization and hemagglutination inhibition assays comparable? Serological results from influenza experimentally infected mallard ducks. Avian Dis 63:138–144

    Google Scholar 

  33. Li Y, Xiao H, Huang C, Sun H, Li L, Su J, Ma J, Liu D, Wang H, Liu W, Gao GF, Li X, Yan J (2015) Distribution of sialic acid receptors and experimental infections with different subtypes of influenza A viruses in Qinghai-Tibet plateau wild pika. Virol J 12:63

    Article  Google Scholar 

  34. Yan Y, Gu JY, Yuan ZC, Chen XY, Li ZK, Lei J, Hu BL, Yan LP, Xing G, Liao M, Zhou JY (2017) Genetic characterization of H9N2 avian influenza virus in plateau pikas in the Qinghai Lake region of China. Arch Virol 162:1025–1029

    Article  CAS  Google Scholar 

  35. Velkers FC, Blokhuis SJ, Veldhuis Kroeze EJB, Burt SA (2017) The role of rodents in avian influenza outbreaks in poultry farms: A review. Vet Q 37:182–194

    Article  Google Scholar 

  36. Grear DA, Dusek RJ, Walsh DP, Hall JS (2017) No evidence of infection or exposure to highly pathogenic avian influenzas in peridomestic wildlife on an affected poultry facility. J Wildl Dis 53:37–45

    Article  Google Scholar 

  37. Shriner SA, Root JJ, Lutman MW, Kloft JM, VanDalen KK, Sullivan HJ, White TS, Milleson MP, Chandler SC, Wolf PC, Turnage CT, McCluskey BJ, Vincent AL, Torchetti MK, Gidlewski T, Deliberto TJ (2016) Surveillance for highly pathogenic H5 avian influenza A virus in synanthropic wildlife associated with poultry facilities during an acute outbreak. Sci Rep 6:36237

    Article  CAS  Google Scholar 

  38. Ellis JW, Shriner SA, McLean HE, Petersen L, Root JJ (2017) Inventory of wildlife use of mortality pits as feeding sites: Implications of pathogen exposure. Hum Wildl Interact 11:8–18

    Google Scholar 

  39. Brown VL, Drake JM, Stallknecht DE, Brown JD, Pedersen K, Rohani P (2013) Dissecting a wildlife disease hotspot: the impact of multiple host species, environmental transmission and seasonality in migration, breeding and mortality. J R Soc Interface 10:20120804

    Article  CAS  Google Scholar 

  40. Shimizu Y, Hayama Y, Yamamoto T, Murai K, Tsutsui T (2018) Matched case-control study of the influence of inland waters surrounding poultry farms on avian influenza outbreaks in Japan. Sci Rep 8:3306

    Article  Google Scholar 

  41. Britton AP, Sojonky KR, Scouras AP, Bidulka JJ (2010) Pandemic (H1N1) 2009 in skunks, Canada. Emerg Infect Dis 16:1043–1045

    Article  Google Scholar 

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Correspondence to J. Jeffrey Root .

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Root, J.J., Shriner, S.A. (2020). Influenza A Viruses in Peridomestic Mammals. In: Spackman, E. (eds) Animal Influenza Virus. Methods in Molecular Biology, vol 2123. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0346-8_32

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  • DOI: https://doi.org/10.1007/978-1-0716-0346-8_32

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0345-1

  • Online ISBN: 978-1-0716-0346-8

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