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Spondyloarthritis: Psoriatic Arthritis

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Encyclopedia of Medical Immunology

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Definition

Psoriatic arthritis (PsA) is an inflammatory musculoskeletal disease associated with psoriasis. Although initially described as seronegative for rheumatoid factor, it has become apparent that some patients with PsA do have a positive rheumatoid factor which may be related to age or other reasons. There are specific features of PsA which help distinguish it from other forms of inflammatory arthritis. Because of its association with extra-articular features, peripheral and axial arthritis, radiological sacroiliitis, and HLA*B27, PsA is classified among the seronegative spondyloarthritis (SpA) group of conditions (Wright and Moll 1976 book).

While the first descriptions of PsA were published in the nineteenth century, it was the efforts of Moll and Wright which led to the recognition of PsA as a specific entity. However, while Moll and Wright considered PsA as a benign condition relative to rheumatoid arthritis (RA), over the past several decades, it has become clear that the...

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References

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Author information

Authors and Affiliations

  1. Centre for Prognosis Studies in the Rheumatic Diseases University of Toronto Psoriatic Arthritis Clinic, Toronto Western Hospital, 399 Bathurst St. 1E-410, Toronto, ON, Canada

    Dafna D. Gladman & Vinod Chandran

Authors
  1. Dafna D. Gladman
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  2. Vinod Chandran
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Corresponding author

Correspondence to Dafna D. Gladman .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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© 2014 Springer Science+Business Media New York

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Gladman, D.D., Chandran, V. (2014). Spondyloarthritis: Psoriatic Arthritis. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_399

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_399

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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