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Calcium Signaling during Phagocytosis

  • Chapter
Molecular Mechanisms of Phagocytosis

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

Phagocytosis is important for a wide diversity of organisms. From simple unicellular organisms that use phagocytosis to eat, to complex metazoans in which phagocytic cells represent an essential branch of the immune system. Evolution has armed cells with a fantastic repertoire of molecules that serve to bring about this complex event regardless of the organism or specific molecules concerned. However, all phagocytic processes are driven by a finely controlled rearrangement of the actin cytoskeleton where calcium (Ca2+) signals play important roles. Ca2+ plays many roles in cytoskeletal changes by affecting the actions of a number of contractile proteins, as well as being a cofactor for the activation of a number of intracellular signaling proteins, known to play important roles during phagocytosis. In the mammalian immune system, the requirement of Ca2+ for the initial steps in phagocytosis, and the subsequent phagosome maturation, can be quite different depending on the type of cell and on the type of receptor that is driving phagocytosis.

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    Alirio J. Melendez

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Melendez, A.J. (2005). Calcium Signaling during Phagocytosis. In: Molecular Mechanisms of Phagocytosis. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-28669-3_9

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