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References
International Fragrance Association (IFRA). Code of practice. Definitions. Home page at: http://www.ifraorg.org
Müller J (1992) The H&R book of perfume. Understanding fragrance. Origin, history, development. Guide to fragrance ingredients. Glöss, Hamburg, Germany
Poucher WA (1993) Poucher’s perfumes, cosmetics and soaps. The production, manufacture and application of perfumes, 9th edn, vol 2. Chapman and Hall, London
Bernard G, Giménez-Arnau E, Rastogi SC, Heydorn S, Johansen JD, Menné T, Goossens A, Andersen K, Lepoittevin JP (2003) Contact allergy to oak moss: search for sensitizing molecules using combined bioassay-guided chemical fractionation, GC-MS, and structure-activity relationship analysis. Arch Dermatol Res 295:229–235
Bauer K, Garbe D, Surburg H (1990) Common fragrance and flavor materials, 2nd edn. VCH Verlagsgesellschaft, Weinheim, Germany
SCCNFP (1998) The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. Opinion concerning fragrance inventory. Adopted by the SCCNFP during the plenary session of 23 September 1998
Johansen JD (2002) Contact allergy to fragrances: clinical and experimental investigations of the fragrance mix and its ingredients. Contact Dermatitis 46(Suppl 3):4–31
Harder U (1998) The art of creating a perfume. In: Frosch PJ, Johansen JD, White IR (eds) Fragrances-beneficial and adverse effects. Springer, Berlin Heidelberg New York, pp 3–5
Lepoittevin JP, Mutterer V (1998) Molecular aspects of fragrance sensitisation. In: Frosch PJ, Johansen JD, White IR (eds) Fragrances — beneficial and adverse effects. Springer, Berlin Heidelberg New York, pp 49–56
Karlberg AT (1998) d-limonene — an old perfume ingredient introduced as a “natural” solvent in industry: is there a risk of sensitization? In: Frosch PJ, Johansen JD, White IR (eds) Fragrances — beneficial and adverse effects. Springer, Berlin Heidelberg New York, pp 106–112
Basketter DA (1992) Skin sensitization to cinnamic alcohol: the role of skin metabolism. Acta Derm Venereol (Stockh) 72:264–265
Nilsson AM, Jonsson C, Luthman K, Nilsson JL, Karlberg AT (2004) Inhibition of the sensitizing effect of carvone by the addition of non-allergenic compounds. Acta Derm Venereol (Stockh) 84:99–105
Karlberg AT, Nilsson AM, Luthman K, Nilsson JL (2001) Structural analogues inhibit the sensitizing capacity of carvone. Acta Derm Venereol (Stockh) 81:398–402
Johansen JD, Skov L, Volund A, Andersen K, Menné T (1998) Allergens in combination have a synergistic effect on the elicitation response: a study of fragrance-sensitized individuals. Br J Dermatol 139:264–270
Grabbe S, Steinert M, Mahnke K, Schwarz A, Luger TA, Schwarz T (1996) Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J Clin Invest 98:1158–1164
Marzulli FN, Maibach HI (1980) Contact allergy: predictive testing of fragrance ingredients in humans by Draize and maximization methods. J Environ Pathol Toxicol 3:235–245
Frankild S (1999) Dose-response studies in guinea pig allergy tests. PhD thesis, Faculty of Health Sciences, University of Southern Denmark, Denmark
Patlewicz GY, Wright ZM, Basketter DA, Pease CK, Lepoittevin JP, Arnau EG (2002) Structure-activity relationships for selected fragrance allergens. Contact Dermatitis 47:219–26
Rastogi SC, Lepoittevin JP, Johansen JD, Frosch P, Menné T, Bruze M, Dreier B, Andersen KE, White I (1998) Fragrances and other materials in deodorants — search for potentially sensitizing molecules using combined GC-MS and structure activity relationship (SAR) analysis. Contact Dermatitis 39:293–303
Patlewicz GY, Basketter DA, Pease CK, Wilson K, Roberts DW, Bernard G, Arnau EG, Lepoittevin JP (2004) Further evaluation of quantitative structure activity relationship models for the prediction of the skin sensitization potency of selected fragrance allergens. Contact Dermatitis 50:91–97
Larsen WG (1977) Perfume dermatitis. A study of 20 patients. Arch Dermatol 113:623–626
Malten KE, van Ketel WG, Nater JP, Liem DH (1984) Reactions in selected patients to 22 fragrance materials. Contact Dermatitis 11:1–10
de Groot AC, Liem DH, Nater JP, van Ketel WG (1985) Patch tests with fragrance materials and preservatives. Contact Dermatitis 12:87–92
Wilkinson JD, Andersen KE, Camarasa J, Ducombs G, Frosch PJ, Lahti A, Menné T, Rycroft RJG, White I (1989) Preliminary results on the effectiveness of two forms of fragrance mix as screening agents for fragrance sensitivity. In: Frosch PJ, Dooms-Goossens A, Lachapelle JM, Rycroft RJG, Sheper RJ (eds) Current topics in contact dermatitis. Springer, Berlin Heidelberg New York, pp 127–131
Frosch PJ, Pilz B, Andersen KE, Burrows D, Camasara JG, Dooms-Goossens A, Ducombs G, Fuchs T, Hannuksela M, Lachapelle JM, Lahti A, Maibach HI, Menne T, Rycroft RJG, Shaw S, Wahlberg JE, White IR, Wilkinson JD (1995) Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes. Contact Dermatitis 33:333–342
Frosch PJ, Johansen JD, Menné T, Pirker C, Rastogi SC, Andersen KE, Bruze M, Goossens A, Lepoittevin JP, White IR (2000) Further important sensitizers in patients sensitive to fragrances. I. Reactivity to 14 frequently used chemicals. Contact Dermatitis 47:78–85
Frosch PJ, Johansen JD, Menné T, Pirker C, Rastogi SC, Andersen KE, Bruze M, Goossens A, Lepoittevin JP, White IR (2002) Further important sensitizers in patients sensitive to fragrances. II. Reactivity to essential oils. Contact Dermatitis 47:279–287
Frosch PJ, Pirker C, Rastogi SC, Andersen KE, Bruze M, Svedman C, Goossens A, White IR, Uter W, Arnau EG, Lepoittevin JP, Menné T, Johansen JD (2005) Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. Contact Dermatitis 52:207–215
Frosch PJ, Rastogi SC, Pirker C, Brinkmeier T, Andersen KE, Bruze M, Svedman C, Goossens A, White IR, Uter W, Arnau EG, Lepoittevin JP, Johansen JD, Menné T (2005) Patch testing with a new fragrance mix — reactivity to the single constituents and chemical detection in relevant cosmetic products. Contact Dermatitis 52:216–225
Larsen W, Nakayama H, Lindberg M, Fischer T, Elsner P, Burrows D, Jordan W, Shaw S, Wilkinson J, Marks J Jr, Sugawara M, Nethercott J (1996) Fragrance contact dermatitis: a worldwide multicenter investigation, part I. Am J Contact Dermatitis 7:77–83
Larsen W, Nakayama H, Fischer T, Elsner P, Frosch P, Burrows D, Jordan W, Shaw S, Wilkinson J, Marks J Jr, Sugawara M, Nethercott M, Nethercott J (2001) Fragrance contact dermatitis: a worldwide multicenter investigation, part II. Contact Dermatitis 44:344–346
Larsen W, Nakayama H, Fischer T, Elsner P, Frosch P, Burrows D, Jordan W, Shaw S, Wilkinson J, Marks J Jr, Sugawara M, Nethercott M, Nethercott J (2002) Fragrance contact dermatitis: a worldwide multicenter investigation, part III. Contact Dermatitis 46:141–144
Larsen W, Nakayama H, Fischer T, Elsner P, Frosch P, Burrows D, Jordan W, Shaw S, Wilkinson J, Marks J Jr, Sugawara M, Nethercott M, Nethercott J (1998) A study of new fragrance mixtures. Am J Contact Dermat 9:202–206
Frosch PJ, Johansen JD, Menné T, Rastogi SC, Bruze M, Andersen KE, Lepoittevin JP, Arnau EG, Pirker C, Goossens A, White IR (1999) Lyral is an important sensitizer in patients sensitive to fragrances. Br J Dermatol 141:1076–1083
Enders F, Przybilla B, Ring J (1989) Patch testing with fragrance mix 16% and 8%, and its individual constituents. Contact Dermatitis 20:237–238
Buckley DA, Wakelin SH, Holloway D, Rycroft RJG, White IR, McFadden JP (2000) The frequency of fragrance allergy in a patch test population over a 17-year period. Br J Dermatol 142:279–283
Meding B, Wrangsjo K, Brisman J, Jarvholm B (2003) Hand eczema in 45 bakers — a clinical study. Contact Dermatitis 48:7–11
Bauer A, Geier J, Elsner P (2002) Type IV allergy in the food processing industry: sensitization profiles in bakers, cooks and butchers. Contact Dermatitis 46:228–235
Rastogi SC, Johansen JD, Menné T (1996) Natural ingredient based cosmetics. Content of selected fragrance sensitizers. Contact Dermatitis 34:423–426
Rastogi SC, Johansen JD, Frosch PJ, Menné T, Bruze M, Lepoittevin JP, Dreier B, Andersen KE, White IR (1998) Deodorants on the European market: quantitative chemical analysis of 21 fragrances. Contact Dermatitis 38:29–35
Rastogi SC, Johansen JD, Menné T, Frosch PJ, Bruze M, Andersen KE, Lepoittevin JP, Wakelin S, White IR (1999) Contents of fragrance allergens in children’s cosmetics and cosmetic-toys. Contact Dermatitis 41:84–88
Johansen JD, Rastogi SC, Menné T (1996) Contact allergy to popular perfumes; assessed by patch test, use test and chemical analysis. Br J Dermatol 135:419–422
Elahi EN, Wright Z, Hinselwood D, Hotchkiss SA, Basketter DA, Pease CK (2004) Protein binding and metabolism influence the relative skin sensitization potential of cinnamic compounds. Chem Res Toxicol 17:301–310
European Communities (2004) Council directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the member states relating to cosmetic products. European Communities Official Journal, L262
Tananka S, Royds C, Buckley D, Basketter DA, Goossens A, Bruze M, Svedman C, Menné T, Johansen JD, White IR, McFadden JP (2004) Contact allergy to isoeugenol and its derivatives: problems with allergen substitution. Contact Dermatitis 51:288–291
Barratt MD, Basketter DA (1992) Possible origin of the skin sensitization potential of isoeugenol and related compounds, (I). Preliminary studies of potential reactions mechanisms. Contact Dermatitis 27:98–104
Bertrand F, Basketter DA, Roberts DW, Lepoittevin JP (1997) Skin sensitization to eugenol and isoeugenol in mice: possible metabolic pathways involving ortho-quinone and quinone methide intermediates. Chem Res Toxicol 10:335–343
Basketter DA, Wright ZM, Warbrick EV, Dearman RJ, Kimber I, Ryan CA, Gerberick GF, White IR (2001) Human potency predictions for aldehydes using the local lymph node assay. Contact Dermatitis 45:89–94
Fenn RS (1989) Aroma chemical usage trends in modern perfumery. Perfumer Flavorist 14:1–10
Goossens A, Merckx L (1997) Allergic contact dermatitis from farnesol in a deodorant. Contact Dermatitis 37:179–180
Schnuch A, Uter W, Geier J, Lessmann H, Frosch PJ (2004) Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. Contact Dermatitis 50:117–121
Heydorn S, Menné T, Andersen KE, Bruze M, Svedman C, White IR, Basketter DA (2003) Citral a fragrance allergen and irritant. Contact Dermatitis 49:32–36
Heydorn S, Johansen JD, Andersen KE, Bruze M, Svedman C, White IR, Basketter DA, Menné T (2003) Fragrance allergy in patients with hand eczema — clinical study. Contact Dermatitis 48:317–323
Rothenborg HW, Menné T, Sjolin KE (1977) Temperature dependent primary irritant dermatitis from lemon perfume. Contact Dermatitis 3:37–48
Mutterer V, Gimenez Arnau E, Lepoittevin JP, Johansen JD, Frosch PJ, Menné T, Andersen KE, Bruze M, Rastogi SC, White IR (1999) Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix. Contact Dermatitis 40:196–199
Kunkeler AC, Weijland JW, Bruynzeel DP (1998) The role of coumarin in patch testing. Contact Dermatitis 39:327–328
Matura M, Goossens A, Bordalo O, Garcia-Bravo B, Magnusson K, Wrangsjo K, Karlberg AT (2003) Patch testing with oxidized R-(+)-limonene and its hydroperoxide fraction. Contact Dermatitis 49:15–21
Matura M, Goossens A, Bordalo O, Garcia-Bravo B, Magnusson K, Wrangsjo K, Karlberg AT (2002) Oxidized citrus oil (R-limonene): a frequent skin sensitizer in Europe. J Am Acad Dermatol 47:709–714
Skold M, Borje A, Matura M, Karlberg AT (2002) Studies on the autoxidation and sensitizing capacity of the fragrance chemical linalool, identifying a linalool hydroperoxide. Contact Dermatitis 46:267–272
Skold M, Borje A, Harambasic E, Karlberg AT (2004) Contact allergens formed on air exposure of linalool. Identification and quantification of primary and secondary oxidization products and effects on skin sensitization. Chem Res Toxicol 17:1697–1705
Schnuch A, Lessmann, Geier J, Frosch PJ, Uter W: IDVK (2004) Contact allergy to fragrances: frequencies of sensitization from 1996 to 2002. Results of the IVDK. Contact Dermatitis 50:65–76
Johansen JD, Andersen KE, Svedman C, Bruze M, Bernard G, Gimenez-Arnau E, Rastogi SC, Lepoittevin JP, Menné T (2003) Chloroatranol, an extremely potent allergen hidden in perfumes: a dose-response elicitation study. Contact Dermatitis 49:180–184
Rastogi SC, Bossi R, Johansen JD, Menné T, Bernard G, Giménez-Arnau E, Lepoittevin JP (2004) Content of oak moss allergens atranol and chloroatranol in perfumes and similar products. Contact Dermatitis 50:367–370
Scientific Committee on Consumer Products (SCCP) (2004) Opinion on atranol and chloroatranol present in natural extracts (e.g. oak moss and tree moss extract). Adopted by SCCP during the 2nd plenary meeting of 7 Dec 2004
Nakayama H (1998) Fragrance hypersensitivity and its control In: Frosch PJ, Johansen JD, White IR (eds) Fragrances — beneficial and adverse effects. Springer, Berlin Heidelberg New York, pp 83–91
Hausen BM, Simatupang T, Bruhn G, Evers P, Koenig WA (1995) Identification of new allergens constituents and proof of evidence for coniferyl benzoate in balsam of Peru. Am J Contact Dermat 6:199–208
Hjorth N (1961) Eczematous allergy to balsams. Allied perfumes and flavoring agents — with special reference to balsam of Peru. Thesis. University of Copenhagen, Denmark
Hausen BM (2001) Contact allergy to balsam of Peru. II. Patch test results in 102 patients with selected balsam of Peru constituents. Am J Contact Dermat 12:93–102
International Fragrance Association (IFRA) (1974) Recommendations concerning Peru balsam. Code of Practice. October 1974, last amended December 1991. Home page at http://www.ifraorg.org
Karlberg AT (2000) Colophony. In: Kanerva L, Elsner P, Wahlberg J, Maibach H (eds) Handbook of occupational dermatology, vol 64. Springer, Berlin Heidelberg New York, pp 509–516
International Fragrance Association (IFRA) Standards. Colophony. Last amended December 1991. Home page at <url>http://www.ifraorg.org</url>
de Groot AC, Frosch PJ (1997) Adverse reactions to fragrances. A clinical review. Contact Dermatitis 36:57–87
Cronin E (1980) Perfumes. Contact dermatitis. Churchill Livingstone, Edinburgh, pp 158–170
Trattner A, David M (2003) Patch testing with fine fragrances: comparison with fragrance mix, balsam of Peru and a fragrance series. Contact Dermatitis 49:287–289
Maouad M, Fleischer AB, Sherertz EF, Feldman SR (1999) Significance-prevalence index number: a reinterpretation and enhancement of data from the North American Contact Dermatitis group. J Am Acad Dermatol 41:573–576
Li LF, Guo J, Wang J (2004) Environmental contact factors in eczema and the results of patch testing Chinese patients with a modified European standard series of allergens. Contact Dermatitis 51:22–25
Greig JE, Carson CF, Stuckey MS, Riley TV (2000) Prevalence of delayed hypersensitivity to the European standard series in a self-selected population. Australas J Dermatol 41:86–89
Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE (2002) Contact allergy and allergic contact dermatitis in adolescents: revalence measures and associations. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). Acta Derm Venereol (Stockh) 82:352–358
Nielsen NH, Menné T (1992) Allergic contact sensitization in an unselected Danish population. The Glostrup Allergy Study. Acta Derm Venereol (Stockh) 72:456–460
Nielsen NH, Linneberg A, Menné T, Madsen F, Frolund L, Dirksen A, Jorgensen T (2001) Allergic contact sensitization in an adult Danish population: two cross-sectional surveys eight years apart (the Copenhagen Allergy Study). Acta Derm Venereol (Stockh) 81:31–34
Schnuch A, Uter W, Geier J, Gefeller O; IDVK study group (2002) Epidemiology of contact allergy: an estimation of morbidity employing the clinical epidemiology and drug-utilization research (CE-DUR) approach. Contact Dermatitis 47:32–39
Marks JG, Belsito DV, DeLeo VA, Fowler JF, Fransway AF, Maibach HI, Mathias Toby CG, Pratt MD, Rietschel RL, Sherertz EF, Storrs FJ, Taylor J (2003) North American Contact Dermatitis Group patch-test results, 1998 to 2000. Am J Contact Dermat 14:59–62
Buckley DA, Rycroft RJG, White IR, McFadden JP (2003) The frequency of fragrance allergy in patch-tested patients increases with their age. Br J Dermatol 149: 986–989
Uter W, Schnuch A (2004) Fragrance allergy increases with age. Br J Dermatol 150:1212–1234
Mortz C, Andersen KE (1999) Allergic contact dermatitis in children and adolescents. Contact Dermatitis 41:121–30
Heine G, Schnuch A, Uter W, Worm M (2004) Frequency of contact allergy in German children and adolescents patch tested between 1995 and 2002: results from the Information Network of Departments of Dermatology and the German Contact Dermatitis Group. Contact Dermatitis 51:111–117
Johansen JD, Menné T, Christophersen J, Kaaber K, Veien N (2000) Changes in the sensitization pattern to common allergens in Denmark between 1985-1986 and 1997-1998, with a special view to the effect of preventive strategies. Br J Dermatol 142:490–495
Scheinman PL (2002) Prevalence of fragrance allergy. Dermatology 205:98–102
Rastogi SC, Menné T, Johansen JD (2003) The composition of fine fragrances is changing. Contact Dermatitis 48:130–132
Johansen JD, Andersen TF, Veien N, Avnstorp C, Andersen KE, Menné T (1997) Patch testing with markers of fragrance contact allergy. Do clinical tests correspond to patients’ self-reported problems?. Acta Derm Venereol (Stockh) 77:149–153
Katz AS, Sheretz F (1999) Facial dermatitis: patch test results and final diagnosis. Am J Contact Dermat 10:153–156
Wöhrl S, Hemmer W, Focke M, Görtz M, Jarisch R (2001) The significance of fragrance mix, balsam of Peru, colophony and propolis as screening tools in the detection of fragrance allergy. Br J Dermatol 145:268–27
Edman B (1994) The influence of shaving method on perfume allergy. Contact Dermatitis 31:291–292
Johansen JD, Andersen TF, Kjøller M, Veien N, Avnstorp C, Andersen KE, Menné T (1998) Identification of risk products for fragrance contact allergy: a case-referent study based on patients’ histories. Am J Contact Dermat 2:80–87
Johansen JD, Rastogi SC, Bruze M, Andersen KE, Frosch PJ, Dreier B, Lepoittevin JP, White IR, Menné T (1998) Deodorants: a clinical provocation study in fragrance-sensitive individuals. Contact Dermatitis 39:161–165
Svedman C, Bruze M, Johansen JD, Andersen KE, Goossens A, Frosch PJ, Lepoittevin JP, Rastogi S, White IR, Menne T (2003) Deodorants: an experimental provocation study with hydroxycitronellal. Contact Dermatitis 48:217–223
Bruze M, Johansen JD, Andersen KE, Frosch P, Lepoittevin JP, Rastogi S, Wakelin S, White I, Menne T (2003) Deodorants: an experimental provocation study with cinnamic aldehyde. J Am Acad Dermatol 48:194–200
von Peter C, Hoting E (1993) Anwendungstest mit parfümierten Kosmetika bei Patienten mit positivem Epikutantest auf Duftsstoff-Mischung. Dermatosen 41:237–241
Heydorn S, Menné T, Johansen JD (2003) Fragrance allergy and hand eczema — a review. Contact Dermatitis 48:59–66
Buckley DA, Rycroft RJG, White IR, McFadden JP (2000) Contact allergy to individual fragrance mix constituents in relation to primary site of dermatitis. Contact Dermatitis 43:304–305
Christophersen J, Menne T, Tanghoj P, Andersen KE, Brandrup F, Kaaber K, Osmundsen PE, Thestrup-Pedersen K, Veien NK (1989) Clinical patch test data evaluated by multivariate analysis. Danish Contact Dermatitis Group. Contact Dermatitis 21:291–299
Katsarma G, Gawkrodger DJ (1999) Suspected fragrance contact allergy requires extended patch testing to individual fragrance allergens. Contact Dermatitis 41:193–197
Veien NK (1989) Systemically induced eczema in adults. Acta Derm Venereol Suppl (Stockh) 147:1–58
Niinimaki A (1995) Double-blind placebo-controlled peroral challenges in patients with delayed-type allergy to balsam of Peru. Contact Dermatitis 33:78–83
Veien NK, Hattel T, Laurberg G (1996) Can oral challenge with balsam of Peru predict possible benefit from a lowbalsam diet? Am J Contact Dermat 7:84–87
Johansen JD, Frosch PJ, Svedman C, Andersen KE, Bruze M, Pirker C, Menné T (2003) Hydroxyisohexyl 3-cyclohexene carboxaldehyde — known as Lyral: quantitative aspects and risk assessment of an important fragrance allergen. Contact Dermatitis 48:310–316
Rastogi SC, Heydorn S, Johansen JD, Basketter D (2001) Fragrance chemicals in domestic and occupational products. Contact Dermatitis 45:221–225
Wallenhammar LM, Ortengren U, Andreasson H, Barregard L, Bjorkner B, Karlsson S, Wrangsjo K, Meding B (2000) Contact allergy and hand eczema in Swedish dentists. Contact Dermatitis 43:192–199
Uter W, Schnuch A, Geier J, Pfahlberg A, Gefeller O; IVDK study group. Information Network of Departments of Dermatology (2001) Association between occupation and contact allergy to the fragrance mix: a multifactorial analysis of national surveillance data. Occup Environ Med 58:392–398
Geier J, Lessmann, Schnuch A, Uter W (2004) Contact sensitization in metalworkers with occupational dermatitis exposed to water-based metalworking fluids: results of the research project “FaSt”. Int Arch Occup Environ Health 77:543–551
Owen CM, August PJ, Beck MH (2000) Contact allergy to oak moss resin in a soluble oil. Contact Dermatitis 43:112
Pontén A, Björk J, Carstensen O, Gruvberger B, Isaksson M, Rasmussen K, Bruze M (2004) Associations between contact allergy to epoxy resin and fragrance mix. Acta Derm Venereol (Stockh) 84:151–175
Larsen WG (1987) Detection of allergic dermatitis to fragrances. Acta Derm Venereol (Stockh) 134:83–86
de Groot AC, van der Kley AM, Bruynzeel DP, Meinardi MM, Smeenk G, van Joost T, Pavel S (1993) Frequency of false-negative reactions to the fragrance mix. Contact Dermatitis 28:139–140
Frosch PJ, Pilz B, Burrows D, Camarasa JG, Lachapelle J-M, Lahti A, Menné T, Wilkinson JD (1995) Testing with fragrance mix. Is the addition of sorbitan sesquioleate to the constituents useful? Contact Dermatitis 32:266–272
Johansen JD, Rastogi SC, Menné T (1996) Exposure to selected fragrance materials. A case study of fragrance-mixpositive eczema patients. Contact Dermatitis 34:106–110
Johansen JD, Rastogi SC, Andersen KE, Menné T (1997) Content and reactivity to product perfumes in fragrance mix positive and negative eczema patients. A study of perfumes used in toiletries and skin-care products. Contact Dermatitis 36:291–296
de Groot AC, Coenraads PJ, Bruynzeel DP, Jagtman BA, van Ginkel CJ, Noz K, van der Valk PG, Pavel S, Vink J, Weyland JW (2000) Routine patch testing with fragrance chemicals in the Netherlands. Contact Dermatitis 42:184–185
Geier J, Brasch J, Schnuch A, Lessmann H, Pirker C, Frosch PJ; For the Information Network of Departments of Dermatology (IVDK) and the German Contact Dermatitis Research Group (DKG) (2002) Lyral has been included in the patch test standard series in Germany. Contact Dermatitis 46:295–297
Roberts G (2002) Procedures for supplying fragrance information to dermatologists. Letter to the editor. Am J Contact Dermat 13:206–207
Gimenez-Arnau A, Gimenez-Arnau E, Serra-Baldrich E, Lepoittevin JP, Camarasa JG (2002) Principles and methodology for identification of fragrance allergens in consumer products. Contact Dermatitis 47:345–352
Arnau EG, Andersen KE, Bruze M, Frosch PJ, Johansen JD, Menné T, Rastogi SC, White IR, Lepoittevin JP (2000) Identification of Lilial as a fragrance sensitizer in a perfume by bioassay-guided chemical fractionation and structure-activity relationships. Contact Dermatitis 43:351–358
Johansen JD, Andersen KE, Rastogi SC, Menné T (1996) Threshold responses in cinnamic-aldehyde-sensitive subjects: results and methodological aspects. Contact Dermatitis 34:165–171
Johansen JD, Andersen KE, Menné T (1996) Quantitative aspects of isoeugenol contact allergy assessed by use and patch tests. Contact Dermatitis 34:414–418
Scheinman PL (2001) Exposing covert fragrance chemicals. Am J Contact Dermat 12:225–228
Scheinman PL (1999) The foul side of fragrance-free products: what every clinician should know about managing patients with fragrance allergy. J Am Acad Dermatol 41:1020–1024
European Communities (2004) Detergents directive 73/404/EEC of 22 Nov 1973, amended 2004
Safford RJ, Basketter DA, Allenby CF, Goodwin BF (1990) Immediate contact reactions to chemicals in the fragrance mix and a study of the quenching action of eugenol. Br J Dermatol 123:595–606
Temesvari E, Nemeth I, Balo-Banga MJ, Husz S, Kohanka V, Somos Z, Judak R, Remenyik EVA, Szegedi A, Nebenführer L, Meszaros C, Horvath A (2002) Multicentre study of fragrance allergy in Hungary. Immediate and late type reactions. Contact Dermatitis 46:325–330
Tanaka S, Matsumoto Y, Dlova N, Ostlere LS, Goldsmith PC, Rycroft RJG, Basketter DA, White IR, Banerjee P, McFadden JP (2004) Immediate contact reactions to fragrance mix constituents and Myroxylon pereirae resin. Contact Dermatitis 51:20–21
Katsarou A, Armenaka M, Ale I, Koufou V, Kalogeromitros D (1999) Frequency of immediate reactions to the European standard series. Contact Dermatitis 41:276–279
Kroon S (1979) Musk Ambrette, a new cosmetic sensitizer and photo sensitizer. Contact Dermatitis 5:337–338
Cronin E (1984) Photosensitivity to musk ambrette. Contact Dermatitis 11:88–92
Darvay A, White IR, Rycroft RJ, Jones AB, Hawk JL, McFadden JP (2001) Photoallergic contact dermatitis is uncommon. Br J Dermatol 145:597–601
Cronin E (1980) Phototoxic reactions. Contact dermatitis. Churchill Livingstone, Edinburgh, pp 417–432
Wang L, Sterling B, Don P (2002) Berloque dermatitis induced by “Florida water”. Cutis 70: 29–30
Elberling J, Linneberg A, Dirksen A, Johansen JD, Frolund L, Madsen F, Nielsen NH, Mosbech H (2005) Mucosal symptoms elicited by fragrance products in a populationbased sample in relation to bronchial hyper-reactivity. Clin Exp Allergy 35:75–81
Kumar P, Caradonna-Graham VM, Gupta S, Cai X, RAO PN, Thompson J (1995) Inhalation challenge effects of perfume scent strips in patients with asthma. Ann Allergy Asthma Immunol 75:429–433
Millqvist E, Lowhagen O (1996) Placebo-controlled challenges with perfume in patients with asthma-like symptoms. Allergy 51:434–439
Millqvist E, Bende M, Lowhagen O (1998) Sensory hyperreactivity — a possible mechanism underlying cough and asthma-like symptoms. Allergy 53:1208–1212
Elberling J, Linneberg A, Mosbech H, Dirksen A, Frolund L, Madsen F, Nielsen NH, Johansen JD (2004) A link between skin and airways regarding sensitivity to fragrance products? Br J Dermatol 151:1197–1203
World Health Organization (1997) Criteria for classification of skin-and airway-sensitizing substances in the work and general environments. Flyvholm M (ed) EUR/ICP/EHPM 050201
References
Balzer W, Braun HJ, Chassot L, Clausen T (2001) Diaminopyrazoles: novel primary intermediates for hair dyeing formulations. Söfw J 127:12–16
Bonnevie P (1939) Aetiologie und pathogenese der Ekzemkrankheiten. Klinische Studien über die Ursachen der Ekzeme unter besonderer Berücksichtigung des Diagnostischen Wertes der Ekzemproben. Busch, Copenhagen/Barth, Leipzig, Germany
Sosted H, Hesse U, Menne T, Andersen KE, Johansen JD (2005) Contact dermatitis to hair dye in an adult Danish population — an interview based study. Br J Dermatol 153:132–135
Nohynek GJ, Fautz R, Benech-Kieffer F, Toutain H (2004) Toxicity and human health risk of hair dyes. Food Chem Toxicol 42:517–543
Sosted H, Agner T, Andersen KE, Menne T (2002) 55 cases of allergic reactions to hair dye: a descriptive, consumer complaint-based study. Contact Dermatitis 47: 299–303
Uter W, Lessmann H, Geier J, Schnuch A (2003) Contact allergy to ingredients of hair cosmetics in female hairdressers and clients — an 8-year analysis of IVDK data. Contact Dermatitis 49:236–240
Cronin E (1980) Hair preparations. In: Cronin E (ed) Contact dermatitis. Churchill Livingstone, Edinburgh, pp 115–126
Hsu TS, Davis MD, el Azhary R, Corbett JF, Gibson LE (2001) Beard dermatitis due to para-phenylenediamine use in Arabic men. J Am Acad Dermatol 44:867–869
Frosch PJ, Burrows D, Camarasa JG, Dooms-Goossens A, Ducombs G, Lahti A, Menne T, Rycroft RJ, Shaw S, White IR et al. (1993) Allergic reactions to a hairdressers’ series: results from 9 European centres. The European Environmental and Contact Dermatitis Research Group (EECDRG). Contact Dermatitis 28:180–183
Aguirre A, Zabala R, Sanz de Galdeano, Landa N, Diaz-Perez JL (1994) Positive patch tests to hydrogen peroxide in 2 cases. Contact Dermatitis 30:113
Brancaccio R, Cohen DE (1995) Contact leukoderma secondary to para-phenylenediamine. Contact Dermatitis 32:313
Sharma VK, Mandal SK, Sethuraman G, Bakshi NA (1999) Para-phenylenediamine-induced lichenoid eruptions. Contact Dermatitis 41:40–41
Tosti A, Bardazzi, F, Valeri F, Toni F (1987) Erythema multiforme with contact dermatitis to hair dyes. Contact Dermatitis 17:321–322
Avnstorp C, Rastogi SC, Menné T (2002) Acute fingertip dermatitis from temporary tattoo and quantitative chemical analysis of the product. Contact Dermatitis 47:119–120
Marcoux D, Couture-Trudel PM, Riboulet-Delmas G, Sasseville D (2002) Sensitization to para-phenylenediamine from a streetside temporary tattoo. Pediatr Dermatol 19:498–502
Sosted H, Menne T (2005) Allergy to 3-nitro-p-hydroxyethylamino-phenol and 4-amino-3-nitrophenol in a hair dye. Contact Dermatitis 52:317–319
Koopmans AK, Bruynzeel DP (2003) Is PPD a useful screening agent? Contact Dermatitis 48:89–92
Sosted H, Basketter DA, Estrada E, Johansen JD, Patlewicz GY (2004) Ranking of hair dye substances according to predicted sensitization potency: quantitative structure-activity relationships. Contact Dermatitis 51:241–254
Blanco R, de la Hoz B, Sanchez-Fernandez C, Sanchez-Cano M (1998) Allergy to 4-amino-3-nitrophenol in a hair dye. Contact Dermatitis 39:136
Ho SG, White IR, Rycroft RJ, McFadden JP (2004) A new approach to patch testing patients with para-phenylenediamine allergy secondary to temporary black henna tattoos. Contact Dermatitis 51:213–214
Krasteva M, Cristaudo A, Hall B, Orton D, Rudzki E, Santucci B, Toutain H, Wilkinson J (2002) Contact sensitivity to hair dyes can be detected by the consumer open test. Eur J Dermatol 12:322–326
Pasche-Koo F, French L, Piletta-Zanin PA, Hauser C (1998) Contact urticaria and shock to hair dye. Allergy 53:904–905
Mavroleon G, Begishvili B, Frew AJ (1998) Anaphylaxis to hair dye: a case report. Clin Exp Allergy 28:121–122
Fukunaga T, Kawagoe R, Hozumi H, Kanzaki T (1996) Contact anaphylaxis due to para-phenylenediamine. Contact Dermatitis 35:185–186
Belton AL, Chira T (1997) Fatal anaphylactic reaction to hair dye. Am J Forensic Med Pathol 18:290–292
Landsteiner J, Jacobs JL (1936) Studies on the sensitization of animals with simple chemical compounds. II. J Exp Med 64:625–629
Mayer RL (1954) Group-sensitization to compounds of quinone structure and its biochemical basis role of these substances in cancer. Prog Allergy 4:79–172
Basketter DA, Liden C (1992) Further investigation into the prohapten concept: reactions to benzene derivatives in man. Contact Dermatitis 27:90–92
Lisi P, Hansel K (1998) Is benzoquinone the prohapten in cross-sensitivity among aminobenzene compounds? Contact Dermatitis 39:304–306
Krasteva M, Nicolas J-F, Chabeau G, Garrigue JL, Bour H, Thivolet J, Schmitt D (1993) Dissociation of allergenic and immunogenic functions in contact sensitivity to para-phenylenediamine. Int Arch Allergy Immunol 102:200–204
McFadden JP, Kullavanijaya P, Duangdeeden I, Fletcher S, Basketter DA (2005) p-Phenylenediamine allergy: the role of Bandrowski’s base. J Clin Immunol (in press)
Kawakubo Y, Merk HF, Masaoudi TA, Sieben S, Blomeke B (2000) N-acetylation of paraphenylenediamine in human skin and keratinocytes. J Pharmacol Exp Ther 292:150–155
Schnuch A, Westphal GA, Muller MM, Schulz TG, Geier J, Brasch J, Merk HF, Kawakubo Y, Richter G, Koch P, Fuchs T, Gutgesell T, Reich K, Gebhardt M, Becker D, Grabbe J, Szliska C, Aberer W, Hallier E (1998) Genotype and phenotype of N-acetyltransferase 2 (NAT2) polymorphism in patients with contact allergy. Contact Dermatitis 38:209–211
Picardo M, Zompetta C, Grandinetti M, Ameglio F, Santucci B, Faggioni A, Passi S (1996) Paraphenylenediamine, a contact allergen, induces oxidative stress in normal human keratinocytes in culture. Br J Dermatol 134:681–685
Mathur AK, Gupta BN, Singh S, Singh A, Narang S (1992) Dermal toxicity of paraphenylenediamine. Biomed Environ Sci 5:321–324
Yokozeki H, Watanabe K, Igawa K, Miyazaki Y, Katayama I, Nishioka K (2001) Gammadelta T cells assist alphabeta T cells in the adoptive transfer of contact hypersensitivity to para-phenylenediamine. Clin Exp Immunol 125:351–359
Sieben S, Kawakubo Y, Al Masaoudi T, Merk HF, Blomeke B (2002) Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones. J Allergy Clin Immunol 109:1005–1011
Kligman A (1966) The identification of contact allergens by human assay. 3. The maximization test: a procedure for screening and rating contact sensitizers. J Invest Dermatol 47:393–409
Marzulli FN, Maibach HI (1974) The use of graded concentrations in studying skin sensitizers: experimental contact sensitization in man. Food Cosmet Toxicol 12:219–227
Basketter DA, Scholes EW (1992) Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens. Food Chem Toxicol 30:65–69
Basketter DA, Gerberick GF (1996) An interlaboratory evaluation of the Buehler test for the identification and classification of skin sensitizers. Contact Dermatitis 35:146–151
Kimber I, Basketter DA, Berthold K, Butler M, Garrigue JL, Lea LJ, Newsome C, Roggeband R, Steiling W, Stropp G, Waterman S, Wiemann C (2001) Skin sensitization testing in potency and risk assessment. Toxicol Sci 59:198–208
Gerberick GF, Ryan CA, Kern PS, Dearman RJ, Kimber I, Patlewicz GY, Basketter DA (2004) A chemical dataset for the evaluation of alternative approaches to skin-sensitization testing. Contact Dermatitis 50:274–288
Armstrong DK, Jones AB, Smith HR, Ross JS, White IR, Rycroft RJ, McFadden JP (1999) Occupational sensitization to p-phenylenediamine: a 17-year review. Contact Dermatitis 41:348–349
Marks JG, Belsito DV, DeLeo VA, Fowler JF Jr, Fransway AF, Maibach HI, Mathias CG, Nethercott JR, Rietschel RL, Sherertz EF, Storrs FJ, Taylor JS (1998) North American Contact Dermatitis Group patch test results for the detection of delayed-type hypersensitivity to topical allergens. J Am Acad Dermatol 38:911–918
Sharma VK, Chakrabarti A (1998) Contact sensitizers in Chandigarh, India. A study of 200 patients with the European standard series. Contact Dermatitis 38:127–131
Schnuch A, Uter W, Geier J, Gefeller O; IVDK study group (2002) Epidemiology of contact allergy: an estimation of morbidity employing the clinical epidemiology and drug-utilization research (CE-DUR) approach. Contact Dermatitis 47:32–39
Schafer T, Bohler E, Ruhdorfer S, Weigl L, Wessner D, Filipiak B, Wichmann HE, Ring J (2001) Epidemiology of contact allergy in adults. Allergy 56:1192–1196 (Erratum: Allergy 57:178, 2002)
Basketter DA, Duangdeeden I, Gilmour NG, Kullavanijaya P, McFadden J (2004) Prevalence of contact allergy in an adult Thai population. Contact Dermatitis 50:128–129
Fautz R, Fuchs A, van der WH, Henny V, Smits L (2002) Hair dye-sensitized hairdressers: the cross-reaction pattern with new generation hair dyes. Contact Dermatitis 46:319–324
Goon AT-J, Gilmour NJ, Basketter DA, White IR, Rycroft RJG, McFadden JP (2003) High frequency of simultaneous sensitivity to Disperse Orange 3 in patients with positive patch tests to para-phenylenediamine. Contact Dermatitis 48:248–250
Seidenari S, Mantovani L, Manzini BM, Pignatti M (1997) Cross-sensitizations between azo dyes and para-amino compound. A study of 236 azo-dye-sensitive subjects. Contact Dermatitis 36:91–96
Herve-Bazin B, Gradiski D, Duprat P, Marignac B, Foussereau J, Cavalier C, Bierber P (1977) Occupational eczema from N-isopropyl-N′-phenylparaphenylenediamine (IPPD) and N-dimethyl-1,3 butyl-N′-phenylparaphenylenediamine (DMPPD) in tyres. Contact Dermatitis 3:1–15
Ho SGY, Basketter DA, Jefferies D, Rycroft RJG, White IR, McFadden JP (2005) Analysis of para-phenylenediamine allergic patients in relation to strength of patch test reaction. Br J Dermatol 153:364–367
Frosch PJ, Burrows D, Camarasa JG, Dooms-Goossens A, Ducombs G, Lahti A, Menne T, Rycroft RJ, Shaw S, White IR et al. (1993) Allergic reactions to a hairdressers’ series: results from 9 European centres. The European Environmental and Contact Dermatitis Research Group (EECDRG). Contact Dermatitis 28:180–183
Uter W, Lessmann H, Geier J, Schnuch A (2003) Contact allergy to ingredients of hair cosmetics in female hairdressers and clients — an 8-year analysis of IVDK data. Contact Dermatitis 49:236–240
Guerra L, Tosti A, Bardazzi F, Pigatto P, Lisi P, Santucci B, Valsecchi R, Schena D, Angelini G, Sertoli A et al. (1992) Contact dermatitis in hairdressers: the Italian experience. Gruppo Italiano Ricerca Dermatiti da Contatto e Ambientali. Contact Dermatitis 26:101–107
Nettis E, Marcandrea M, Colanardi MC, Paradiso MT, Ferrannini A, Tursi A (2003) Results of standard series patch testing in patients with occupational allergic contact dermatitis. Allergy 58:1304–1307
European Communities (2004) Council directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the member states relating to cosmetic products, annex III amended. European Communities Official Journal, L262
Sosted H, Rastogi SC, Andersen KE, Johansen JD, Menne T (2004) Hair dye contact allergy: quantitative exposure assessment of selected products and clinical cases. Contact Dermatitis 50:344–348
Guerra L, Bardazzi F, Tosti A (1992) Contact dermatitis in hairdressers’ clients. Contact Dermatitis 26:108–111
Vilaplana J, Romaguera C, Grimalt F (1991) Contact dermatitis from resorcinol in a hair dye. Contact Dermatitis 24:151–152
Garcia Ortiz JC, Terron M, Bellido J (1997) Contact allergy to henna. Int Arch Allergy Immunol 114:298–299
Perez RG, Gonzalez R, Gonzalez M, Soloeta R (2003) Palpebral eczema due to contact allergy to henna used as a hair dye. Contact Dermatitis 48:238
Nigam PK, Saxena AK (1988) Allergic contact dermatitis from henna. Contact Dermatitis 18:55–56
Bolhaar ST, Mulder M, van Ginkel CJ (2001) IgE-mediated allergy to henna. Allergy 56:248
Majoie IM, Bruynzeel DP (1996) Occupational immediatetype hypersensitivity to henna in a hairdresser. Am J Contact Dermat 7:38–40
Fisher AA, Dooms-Goossens A (1976) Persulfate hair bleach reactions. Cutaneous and respiratory manifestations. Arch Dermatol 112:1407–1409
Bowling JC, Scarisbrick J, Warin AP, Downs AM (2002) Allergic contact dermatitis from trideceth-2-carboxamide monoethanolamine (MEA) in a hair dye. Contact Dermatitis 47:116–117
Kligman AM (1966) The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis. J Invest Dermatol 47:375–392
Chan YC, Ng SK, Goh CL (2001) Positive patch-test reactions to para-phenylenediamine, their clinical relevance and the concept of clinical tolerance. Contact Dermatitis 45:217–220
Edwards EK Jr, Edwards EK (1982) Allergic contact dermatitis to lead acetate in a hair dye. Cutis 30:629–630
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Johansen, J.D., Lepoittevin, JP., Basketter, D., McFadden, J., Søsted, H. (2006). Allergens of Special Interest. In: Frosch, P.J., Menné, T., Lepoittevin, JP. (eds) Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31301-X_31
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