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What We Know and Do Not Know About Actin

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The Actin Cytoskeleton

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 235))

Abstract

Seven decades of research have revealed much about actin structure, assembly, regulatory proteins, and cellular functions. However, some key information is still missing, so we do not understand the mechanisms of most processes that depend on actin. This chapter summarizes our current knowledge and explains some examples of work that will be required to fill these gaps and arrive at a mechanistic understanding of actin biology.

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Acknowledgments

Research from the author’s laboratory reported in this publication was supported by National Institute of General Medical Sciences of the National Institutes of Health under award numbers R01GM026132 and R01GM026338. The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health.

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Authors and Affiliations

  1. Department of Molecular Cellular and Developmental Biology, Yale University, 208103, New Haven, CT, 06520-8103, USA

    Thomas D. Pollard

  2. Department of Molecular Biophysics and Biochemistry, Yale University, 208103, New Haven, CT, 06520-8103, USA

    Thomas D. Pollard

  3. Department of Cell Biology, Yale University, 208103, New Haven, CT, 06520-8103, USA

    Thomas D. Pollard

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Correspondence to Thomas D. Pollard .

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  1. Cell Biology, Life Sciences, BRICS, TU Braunschweig, Braunschweig, Germany

    Brigitte M. Jockusch

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Pollard, T.D. (2016). What We Know and Do Not Know About Actin. In: Jockusch, B. (eds) The Actin Cytoskeleton. Handbook of Experimental Pharmacology, vol 235. Springer, Cham. https://doi.org/10.1007/164_2016_44

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