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Biotransformation and Enzymatic Reactions of Synthetic Pyrethroids in Mammals

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Pyrethroids

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 314))

Abstract

Synthetic pyrethroids, a major insecticide group, are used worldwide for controlling indoor and agricultural pests. Extensive mammalian metabolism studies have been carried out since the late 1960s, and major metabolic reactions have been found to be oxidation of the acid or alcohol moiety, ester cleavage, and conjugation reactions. In addition, various conjugation reactions occur in mammals, forming hydrophilic and lipophilic conjugates. Pyrethroids are generally rapidly metabolized in mammals and completely excreted from the body in a short period. Human and laboratory animals share similar metabolic reactions for pyrethroids. Oxidation reactions in humans are mediated by several CYP isoforms. On the other hand, ester bonds of pyrethroids are hydrolyzed mainly by carboxylesterase(s).

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Authors and Affiliations

  1. Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, 1-98-3 Kasugadenaka, Konohana-Ku, Osaka, 554-8558, Japan

    Kazuki Mikata, Naohiko Isobe & Hideo Kaneko

Authors
  1. Kazuki Mikata
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  2. Naohiko Isobe
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  3. Hideo Kaneko
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Correspondence to Hideo Kaneko .

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Editors and Affiliations

  1. Dainihon Jochugiku Co. Ltd., 1-chome, Daikoku-cho, Toyonaka-shi 1-11, Osaka, 561-0827, Japan

    Noritada Matsuo

  2. Sumitomo Chemical Co.Ltd., Takatsukasa 4-2-1, Takarazuka-city, 665-8555, Hyogo, Japan

    Tatsuya Mori

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Mikata, K., Isobe, N., Kaneko, H. (2011). Biotransformation and Enzymatic Reactions of Synthetic Pyrethroids in Mammals. In: Matsuo, N., Mori, T. (eds) Pyrethroids. Topics in Current Chemistry, vol 314. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_254

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