Conclusion
The in vitro hemolytic activity directed by the two hly operons of strain 536 differ significantly,which is probably the effect of the different transcriptional rate.
While the coding regions of the two hly determinants are 96% homologous,no similarity can be found in the 5’ flanking regions (except the 8 bp ops motif).The dissimilar upstream elements may explain the different expression of the operons.
Loss of the pathogenicity islands carrying the hemolysin determinants results in an avirulent phenotype.
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Nagy, G., Dobrindt, U., Blum-Oehler, G., Emoődy, L., Goebel, W., Hacker, J. (2002). Analysis of the Hemolysin Determinants of the Uropathogenic Escherichia coli Strain 536. In: Emoődy, L., Pál, T., Hacker, J., Blum-Oehler, G. (eds) Genes and Proteins Underlying Microbial Urinary Tract Virulence. Advances in Experimental Medicine and Biology, vol 485. Springer, Boston, MA. https://doi.org/10.1007/0-306-46840-9_7
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