Skip to main content
SpringerLink
Log in

Red pigment produced by Zooshikella ganghwensis inhibited the growth of human cancer cell lines and MMP-1 gene expression

  • Note
  • Published:
Applied Biological Chemistry Submit manuscript

Abstract

A red pigment produced by Zooshikella ganghwensis, was purified by solvent extraction and fractionation. The pigment was identified to be prodigiosin on the basis of spectroscopic data such as 1H-NMR, 13C-NMR, DEPT, 2D-NMR, IR, and FAB-MS. Prodigiosin inhibited matrix metalloproteinase-1 gene expression and the growth of human cancer cell lines, SK-BR-3, HCT-116, SK-OV-3, HeLa, HepG2, and SK-MEL-5.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  • Aberoumand A (2011) A review article on edible pigments properties and sources as natural biocolorants in foodstuff and food industry. World J Dairy Food Sci 6:71–78

    Google Scholar 

  • Castro AJ (1967) Antimalarial activity of prodigiosin. Nature 213:903–904

    Article  CAS  Google Scholar 

  • Dong KK, Damaghi N, Picart SD, Markova NG, Obayashi K, Okano Y, Masaki H, Grether-Beck S, Krutmann J, Smiles KA, Yarosh DB (2008) UV-induced DNA damage initiates release of MMP-1 in human skin. Exp Dermatol 17:1037–1044

    Article  CAS  Google Scholar 

  • Khanafari A, Assadi MM, Fakhr FA (2006) Review of prodigiosin, pigmentation in Serratia marcescens. J Biol Sci 6:1–13

    Article  Google Scholar 

  • Maheswarappa G, Kavitha D, Vijayarani K, Kumanan K (2013) Prodigiosin as anticancer drug produced from bacteria of termite gut. Indian J Basic Appl Med Res 3:257–266

    Google Scholar 

  • Mangione L, Scoglio ME, Alonzo V (1976) Antibacterial activity of prodigiosin. Atti Soc Pelorit Sci Fis Mat Nat 22:149–160

    CAS  Google Scholar 

  • Venil CK, Lakshmanaperumalsamy P (2009) An insightful overview on microbial pigment, prodigiosin. Electron J Biol 5:49–61

    Google Scholar 

  • Venil CK, Zakariab ZA, Ahmada WA (2013) Bacterial pigments and their applications. Process Biochem 48:1065–1079

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This study was financially supported from the Korea Health Industry Development Institute (Grant No. HN11C0044).

Author information

Authors and Affiliations

  1. Department of Oriental Medicine and Biotechnology, Graduate School of Biotechnology, Kyung Hee University, Yongin, 446-701, Republic of Korea

    Eun-Ji Oh, Jung-Hwa Kwon, Su-Yeon Kim, Seo-Ji In, Jeon Hwang-Bo, In-Sik Chung & Nam-In Baek

  2. Research and Development Center, GFC Co., Ltd., Suwon, 443-813, Republic of Korea

    Dong-Geol Lee, Mi-Yeon Cha & Hee-Cheol Kang

  3. Department of Horticultural Biotechnology, Kyung Hee University, Yongin, 446-701, Republic of Korea

    Youn-Hyung Lee

Authors
  1. Eun-Ji Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jung-Hwa Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Su-Yeon Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Seo-Ji In
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dong-Geol Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mi-Yeon Cha
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hee-Cheol Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jeon Hwang-Bo
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Youn-Hyung Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. In-Sik Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Nam-In Baek
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nam-In Baek.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oh, EJ., Kwon, JH., Kim, SY. et al. Red pigment produced by Zooshikella ganghwensis inhibited the growth of human cancer cell lines and MMP-1 gene expression. Appl Biol Chem 59, 567–571 (2016). https://doi.org/10.1007/s13765-016-0196-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13765-016-0196-1

Keywords

Search

Navigation