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Long noncoding RNA HOTAIR involvement in cancer

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Tumor Biology

Abstract

Evidences have been provided that long noncoding RNAs (lncRNAs) act as key molecules in epigenetic regulation and are involved in the development process of cancer in recent studies. HOX transcript antisense RNA (HOTAIR), a long intergenic noncoding RNA (lincRNA), functions as a molecular scaffold to link and target two histone modification complexes PRC2 and LSD1, then reprograms chromatin states by couples histone H3K27 methylation and H3K4 demethylation for epigenetic gene silencing to promote cancer metastasis. HOTAIR, regarded as an oncogene, is pervasively overexpressed in most solid cancers and correlated with tumor invasion, progression, metastasis, and poor prognosis, and HOTAIR has been proven to play a critical role in most biological process of cancer and would be a potential new target in cancer therapy.

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Authors and Affiliations

  1. Department of Maxillofacial and Otorhinolaryngology Head & Neck Surgery, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People’s Republic of China

    Yansheng Wu, Xudong Wang & Lun Zhang

  2. Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People’s Republic of China

    Xiubao Ren

  3. Biotherapy Center, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People’s Republic of China

    Yang Wang, Hui Li, Xiubao Ren, Feng Wei, Wenwen Yu, Jinpu Yu & Xishan Hao

  4. National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China

    Yansheng Wu, Yang Wang, Hui Li, Xiubao Ren, Feng Wei, Wenwen Yu, Xudong Wang, Lun Zhang, Jinpu Yu & Xishan Hao

  5. Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, People’s Republic of China

    Yang Wang, Hui Li, Xiubao Ren, Feng Wei, Wenwen Yu, Jinpu Yu & Xishan Hao

  6. Department of Breast Cancer Medical Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People’s Republic of China

    Li Zhang

  7. Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China

    Li Zhang

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  1. Yansheng Wu
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  2. Li Zhang
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  9. Lun Zhang
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  10. Jinpu Yu
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Corresponding authors

Correspondence to Jinpu Yu or Xishan Hao.

Additional information

Yansheng Wu and Li Zhang contributed equally to this manuscript.

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Wu, Y., Zhang, L., Wang, Y. et al. Long noncoding RNA HOTAIR involvement in cancer. Tumor Biol. 35, 9531–9538 (2014). https://doi.org/10.1007/s13277-014-2523-7

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  • DOI: https://doi.org/10.1007/s13277-014-2523-7

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