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Gastric Cancer and Paraneoplastic Pemphigus

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Abstract

Paraneoplastic pemphigus is a relatively rare but significant acquired autoimmune mucocutaneous disorder that is characterised by diffuse erythema, painful blistering and sores of the skin and mucus membranes. The underlying pathogenesis is believed to be triggered by altered immune system in response to underlying neoplasm. The manifestations can predate, occur at the same time or after the diagnosis of cancer. Associations with gastric cancer have only been reported twice. A 78-year-old lady presented with a month’s history of extensive skin lesions that started off as bullous lesions and biopsy revealed bullous pemphigus. Endoscopy for anemia revealed gastric cancer. This case reinforced the need to consider underlying malignancy in elderly patient with new onset dermatological presentation.

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The authors declare that they have no competing interest.

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Authors and Affiliations

  1. Endoscopy Unit, RIPAS Hospital, Bandar Seri Begawan, BA 1710, Brunei

    Norwani Basir & Vui Heng Chong

  2. Department of Pathology, RIPAS Hospital, Bandar Seri Begawan, BA 1710, Brunei

    Pemasari Upali Telisinghe

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  1. Norwani Basir
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  2. Pemasari Upali Telisinghe
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  3. Vui Heng Chong
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Correspondence to Vui Heng Chong.

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Basir, N., Telisinghe, P.U. & Chong, V.H. Gastric Cancer and Paraneoplastic Pemphigus. Indian J Surg 77, 545–546 (2015). https://doi.org/10.1007/s12262-015-1311-y

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  • DOI: https://doi.org/10.1007/s12262-015-1311-y

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