In vitro experiments showed that heparin adsorbed on activated charcoal can bind antibodies raised against native and single-stranded DNA in a diluted sera pool with a high level of these DNA. Thus, heparin used as anticoagulant during hemosorption procedure can demonstrate supplementary therapeutic activity resulting from its interaction with various agents involved in acute and chronic inflammatory reactions such as DNA- and RNA-binding substances, proinflammatory cytokines, complement components, growth factors, etc. Research and development of heparin-containing carbonic adsorbents for the therapy of numerous inflammatory and autoimmune diseases seems to be a promising avenue in hematology.
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References
Yu. M. Lopukhin and M. N. Molodenkov, Hemosorption [in Russian], Moscow (1985).
V. G. Nikolaev, Method of Hemocarboperfusion in Experiments and Clinics [in Russian], Kiev (1984).
O. Ben-Zaken, S. Tzaban, Y. Tal, et al., J. Biol. Chem., 278, No. 41, 40,041-40,049 (2003).
P. W. Derksen, R. M. Keehnen, L. M. Evers, et al., Blood, 99, No. 4, 1405-1410 (2002).
T. M. Handel, Z. Johnson, S. E. Crown, et al., Annu. Rev. Biochem., 74, 385-410 (2005).
W. Koopmann, C. Ediriwickrema, and M. S. Krangel, J. Immunol., 163, No. 4, 2120-2127 (1999).
A. Linder, O. Soehnlein, and P. Akesson, J. Innate Immun., 2, No. 5, 431-438 (2010).
Y. Ling, Z. Y. Yang, T. Yin, et al., Int. Immunopharmacol., 11, No. 2, 187-193 (2011).
S. J. Patey, E. A. Edwards, E. A. Yates, and J. E. Turnbull, Neurodegener. Dis., 5, Nos. 3-4, 197-199 (2008).
J. M. D. Tascon, Novel Carbon Adsorbents, Oxford (2012).
H. Tsujioka, F. Yotsumoto, S. Hikita, et al., Curr. Opin. Obstet. Gynecol., 23, No. 1, 24-30 (2011).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 442-445, October, 2015
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Snezhkova, E.A., Tridon, A., Evrard, B. et al. Binding Potency of Heparin Immobilized on Activated Charcoal for DNA Antibodies. Bull Exp Biol Med 160, 444–447 (2016). https://doi.org/10.1007/s10517-016-3192-x
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DOI: https://doi.org/10.1007/s10517-016-3192-x