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Placental expression of indoleamine 2,3-dioxygenase

Expression von Indolamin 2,3-dioxygenase in der Plazenta

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Zusammenfassung

Diese Übersicht beleuchtet die Expression des Tryptophan-abbauenden Enzyms Indolamin 2,3-dioxygenase-1 (IDO1) und diskutiert eine Reihe von möglichen Funktionen, die über Immunsuppression and antimikrobielle Aktivität bis zur plazentaren Vasodilatation reichen – letztere basierend auf der endothelialen Expression von IDO zu beiden Seiten der fetomaternalen Grenze.

Summary

This review focuses on the placental expression of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase-1 (IDO1) and its potential roles, which may not only encompass immunosuppression and antimicrobial activity, but also vasodilation based on the endothelial expression on both sides of the feto-maternal interface.

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  1. Center for Molecular Medicine, Institute for Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria

    Peter Sedlmayr & Astrid Blaschitz

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  1. Peter Sedlmayr
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  2. Astrid Blaschitz
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Correspondence to Peter Sedlmayr.

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Sedlmayr, P., Blaschitz, A. Placental expression of indoleamine 2,3-dioxygenase. Wien Med Wochenschr 162, 214–219 (2012). https://doi.org/10.1007/s10354-012-0082-3

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  • DOI: https://doi.org/10.1007/s10354-012-0082-3

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