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Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis

  • Case Report
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Modern Rheumatology

Abstract

We report two cases of hydralazine-induced vasculitis with rare complications: pulmonary renal syndrome and digital gangrene. We also review 68 published cases of hydralazine-induced vasculitis. Hydralazine-induced vasculitis mimics idiopathic antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis. However, it also produces other autoantibodies, such as antinuclear antibodies, antihistone antibodies, anti-dsDNA antibodies, and antiphospholipid antibodies. Patients with hydralazine-induced vasculitis typically have a more severe course than those with hydralazine-induced lupus, predominantly due to renal vasculitis, and require a more aggressive treatment.

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Acknowledgments

The authors thank Dr. Jyothi Jagadeesh for collecting clinical information of patient 1.

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Authors and Affiliations

  1. Division of Rheumatology, University of Pennsylvania, 3600 Spruce Street-507 Maloney Bldg, Philadelphia, PA, 19104-4283, USA

    Naoto Yokogawa & Frederick B. Vivino

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  1. Naoto Yokogawa
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  2. Frederick B. Vivino
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Correspondence to Naoto Yokogawa.

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Yokogawa, N., Vivino, F.B. Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis. Mod Rheumatol 19, 338–347 (2009). https://doi.org/10.1007/s10165-009-0168-y

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  • DOI: https://doi.org/10.1007/s10165-009-0168-y

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