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The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma

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Abstract

Angiocentric glioma (AG) has been formally codified in the revised 2007 WHO Classification of Tumours of the Central Nervous System. AGs characteristically exhibit mixed features of ependymal and diffuse astrocytic differentiation and low proliferation rates, with Ki-67 labeling indices ranging from less than 1 to 5%. A single case with anaplastic recurrence and a labeling index of 10% has been reported. In the present study, we report a series of three AGs (Case 1: 4-year-old girl at right frontal lobe; Case 2: 4-year-old boy at left frontal lobe; Case 3: 9-year-old boy at right temporal lobe). Case 1 with elevated proliferation index (~10%) and increased mitotic activity (six mitoses per 10 high-power fields) on phospho-histone H3 (pHH3) immunostain at presentation, nonetheless, has shown protracted recurrence-free survival after 6 years of follow-up. So far, this is the first report for evaluating the mitotic activity in AGs using pHH3 immunostain.

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Authors and Affiliations

  1. Department of Pathology and Lab. Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine, 6 Ohio Drive, Suite 202, Lake Success, NY, 11042, USA

    Jian Yi Li

  2. Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, USA

    Lauren A. Langford & Gregory N. Fuller

  3. Department of Pathology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA

    Adekunle Adesina

  4. Department of Pathology, Covenant Children’s Hospital, Lubbock, TX, USA

    Surender R. Bodhireddy

  5. Austin Pathology Associates, 601 E 15th St, Austin, TX, USA

    Min Wang

Authors
  1. Jian Yi Li
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  2. Lauren A. Langford
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  3. Adekunle Adesina
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  4. Surender R. Bodhireddy
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  5. Min Wang
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  6. Gregory N. Fuller
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Corresponding authors

Correspondence to Jian Yi Li or Gregory N. Fuller.

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Li, J.Y., Langford, L.A., Adesina, A. et al. The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma. Brain Tumor Pathol 29, 68–72 (2012). https://doi.org/10.1007/s10014-011-0062-0

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  • DOI: https://doi.org/10.1007/s10014-011-0062-0

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