Skip to main content
SpringerLink
Log in

TT virus (TTV) is not associated with acute sporadic hepatitis

  • Brief Report
  • Published:
Infection Aims and scope Submit manuscript

Summary

A novel virus, TT virus (TTV), recently discovered byOkamoto et al. in the serum of a patient with posttransfusion hepatitis, is thought to be one of the causative agents of blood-borne acute hepatitis. The association of this virus with acute sporadic hepatitis was evaluated. TTV DNA was detected in 4 (4.9%) of 81 cases of acute hepatitis A, in 5 (16.7%) of 30 cases of acute hepatitis B, in 1 (25.0%) of 4 cases of acute hepatitis C, in 1 (9.1%) of 9 cases of cytomegalovirus and Eppstein-Barr infection, and in 8 (13.6%) of 59 cases of acute hepatitis of unknown etiology. These positive rates of TTV in various etiologies did not differ significantly amongst each other, and were similar to those of healthy volunteers, i.e. 12.0% (12/100). The comparison of levels of alamine aminotransferase, aspartate aminotransferase, total bilirubin, hepaplastin test and prothrombin time between TT virus-positive and- negative patients did not show any differences. This indicates that TTV is neither a main causative agent of acute sporadic hepatitis of unknown etiology, nor does it affect the clinical features of acute hepatitis with already known etiology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Nishizawa, T., Okamoto, H., Konishi, K., Yoshizawa, H., Miyakawa, Y., Mayumi, M.: A novel virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem. Biophys. Res. Commun. 241 (1997) 92–97.

    Article  CAS  Google Scholar 

  2. Okamoto, H., Nishizawa, T., Kato, N., Ukita, M., Ikeda, H., Iizuka, H., Miyakawa, Y., Mayumi, M.: Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology. Hepatol. Res. 10 (1998) 1–16.

    Article  Google Scholar 

  3. Sumazaki, R., Yamada-Osaki, M., Kajiwara, Y., Shirahata, A., Matsui, A.: Transfusion transmitted virus. Lancet 352 (1998) 1308–1309.

    Article  PubMed  CAS  Google Scholar 

  4. Alter, H. J., Nakatsuji, Y., Melpolder, J., Wages, J., Wesley, R., Wesley, R., Shih, J. W., Kim, J. P.: The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease. N. Engl. J. Med. 336 (1997) 747–754.

    Article  PubMed  CAS  Google Scholar 

  5. Yamada-Osaki, M., Sumazaki, R., Noguchi, E., Shibasaka, M., Matsui, A.: Transfusion-transmitted virus. Lancet 352 (1998) 1309–1310.

    Article  PubMed  CAS  Google Scholar 

  6. Brown, K. E., Green, S. W., Young, N. S.: Goose parvovirus—an autonomous member of the dependovirus genus? Virology 210 (1995) 283–291.

    Article  PubMed  CAS  Google Scholar 

  7. Almeida, J. D., Deinhardt, F., Holmes, A. W., Peterson, D. A., Wolfe, L., Zuckerman, A. J.: Morphology of the GB hepatitis agent. Nature 261 (1976) 608–609.

    Article  PubMed  CAS  Google Scholar 

  8. Appleton, H.: Virus particles in marmosets hepatitis. Nature 267 (1977) 729–730.

    Article  PubMed  CAS  Google Scholar 

  9. Yoto, Y., Kudoh, T., Haseyama, K., Suzuki, N., Chiba, S.: Human parvovirus B19 infection associated with acute hepatitis. Lancet 347 (1996) 868–869.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Second Dept. of Internal Medicine, Nagoya University School of Medicine, 65 Tsuruma, Showa, 466-855, Nagoya, Japan

    Y. Fukuda M.D., I. Nakano M.D., Y. Katano M.D. & T. Hayakawa M.D.

  2. Dept. of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan

    T. Kumada M.D., K. Hayashi M.D. & S. Nakano M.D.

Authors
  1. Y. Fukuda M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Nakano M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Katano M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Kumada M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Hayashi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Nakano M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. T. Hayakawa M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fukuda, Y., Nakano, I., Katano, Y. et al. TT virus (TTV) is not associated with acute sporadic hepatitis. Infection 27, 125–127 (1999). https://doi.org/10.1007/BF02560512

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02560512

Keywords

Search

Navigation