Abstract
The hemostatic effect of tranexamic acid (TA) was evaluated in patients undergoing coronary artery bypass grafting (CABG). The subjects were 33 serial patients who underwent elective CABG performed by the same team between January 1997 and April 2000. They were divided into a group that received TA (n=15) and a non-TA control group (n=18). The TA group received 50mg/kg of TA intravenously before starting cardiopulmonary bypass (CPB) and 25 mg/kg immediately after CPB. Blood loss from the end of CPB to completion of surgery (post-CPB), as well as during the first 6h (BL6), 6–12 h (BL6–12), 12–18h (BL12–18), and 18–24h after surgery (BL18–24), was compared between the two groups. The time of chest tube removal, the volume of blood transfused, and graft patency were also compared. The blood loss at BL6, BL6–12, BL12–18, and BL18–24, as well as the blood transfussion volume, were all significantly (P<0.05) lower in the TA group than in the control group. There was no significant difference in graft patency between the two groups. In CABG patients, TA reduced blood loss without affecting graft patency, suggesting that it is useful in this setting.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Soslou G, Horrow J, Brodsky I. The effect of tranexamic, acid on platelet ADP during extracorporeal circulation. Am J Hematol 1991;38:113–119
Katsaros D, Petricevic M, Snow NJ, Woodhall DD, Bergen RV, Tranexamic acid reduces postbypass blood use: a double blinded, prospective, randomized study of 210 patients. Ann Thorac Surg 1996;61:1131–1135
Karski JM, Teasdale SJ, Norman PH. Prevention of bleeding after cardiopulmonary bypass with high-dose tranexamic acid: double-blind, randomized clinical trial. J Thorac Cardiovasc Surg 1995;110:835–842
Horrow JC, Van Riper DF, Strong MD, Brodsky I, Parmet JL. Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery. Circulation 1991;84:2063–2070
Horrow JC, Hlavacek J, Strong MD, Collier W, Brodsky I, Goldman SM, Goel IP. Prophylactic tranexamic acid decreases bleeding after cardiac operations. J Thorac Cardiovasc Surg 1990;99:70–74
Osaka M, Fukuda I, Ohuchi H. Aprotinin and recombinant human erythropoietin reduce the need for homologous blood transfusion in cardiac surgery. J Jpn Assn Thorac Surg 1998;46:846–853
Bidstrup BP, Underwood SR, Sapsford RN. Effect of aprotinin (trasylol) on aorta-coronary bypass graft patency. J Thorac Cardiovasc Surg 1993;105:147–153
Havel M, Grabenwoger F, Schneider J, Laufer G, Wollenek G, Owen A, Simon P, Teufelsbauer H, Wolner E. Aprotinin does not decrease early graft patency after coronary artery bypass grafting despite reducing postoperative bleeding and use of donated blood. J Thorac Cardiovasc Surg 1994;107:807–810
Minohara S-I, Asada K, Kondo K-I, Tatsumi T, Hasegawa S, Sawada Y, Morimoto T, Matsuyama N, Sasaki S. Effect of aprotinin on bleeding during and graft patency after coronary artery bypass grafting. J Jpn Assn Thorac Surg 1997;45:821–824
Lemmer JH Jr, Stanford W, Bonney SL, Breen JF, Chomka EV, Eldredge WJ, Holt WW, Karp RB, Laub GW, Lipton MJ, Schaff HV, Tatooles CJ, Rumberger JA. Aprotinin for coronary bypass operations. Efficacy, safety, and influence on eariy saphenous vein graft patency. A multicenter, randomized, double-blind, placebo-controlled study. J Thorac Cardiovasc Surg 1994;107:543–553
Laub GW, Riebman JB, Chen C, Adkins MS, Anderson MA, Fernandez J, McGrath LB. The impact of aprotinin on coronary artery bypass graft patency. Chest 1994;106:1370–1375
Bukhari EA, Krukenkamp IB, Burns PG, Gaudette GR, Schulman JJ, Al-Fagih MR, Levitsky S. Does aprotinin increase the myocardial damage in the setting of ischemia and precoditioning? Ann Thorac Surg 1995;60:307–310
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kohno, K., Kimura, S., Kashima, T. et al. Hemostatic effect of tranexamic acid (transamin) during coronary artery bypass grafting. J Artif Organs 4, 241–244 (2001). https://doi.org/10.1007/BF02479901
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02479901