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“FunctionType” is a concept of identification (generated from the IDENTIFICATION axiom) of IMGT-ONTOLOGY, the global reference in immunogenetics and immunoinformatics (Giudicelli and Lefranc 1999; Lefranc et al. 2004, 2005, 2008; Duroux et al. 2008), built by IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org) (IMGT® Information System), that allows to identify the type of function. In molecular biology, “FunctionType” allows to identify the type of function of a Molecule_EntityType leafconcept.
Thus, for example, the “FunctionType” concept allows to identify:
- 1.
For the immunoglobulins (IG) or antibodies and the T cell receptors, that are the antigen receptors of the adaptive immune response, the function of “antigen binding” and “antigen recognition” by the variable (V) domains (Variable (V) Domain) of the specific antigen receptors, these types of functions being strongly related with the “SpecificityType” concept that...
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References
Duroux P, Kaas Q, Brochet X, Lane J, Ginestoux C, Lefranc M-P, Giudicelli V (2008) IMGT-Kaleidoscope, the Formal IMGT-ONTOLOGY paradigm. Biochimie 90:570–583
Giudicelli V, Lefranc M-P (1999) Ontology for immunogenetics: the IMGT-ONTOLOGY. Bioinformatics 12:1047–1054
Lefranc M-P, Giudicelli V, Ginestoux C, Bose N, Folch G, Guiraudou D, Jabado-Michaloud J, Magris S, Scaviner D, Thouvenin V, Combres K, Girod D, Jeanjean S, Protat C, Yousfi Monod M, Duprat E, Kaas Q, Pommié C, Chaume D, Lefranc G (2004) IMGT-ONTOLOGY for immunogenetics and immunoinformatics. In Silico Biol 4:17–29
Lefranc M-P, Clément O, Kaas Q, Duprat E, Chastellan P, Coelho I, Combres K, Ginestoux C, Giudicelli V, Chaume D, Lefranc G (2005) IMGT-Choreography for immunogenetics and immunoinformatics. In Silico Biol 5:45–60
Lefranc M-P, Giudicelli V, Regnier L, Duroux P (2008) IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics. Brief Bioinform 9:263–275
Magdelaine-Beuzelin C, Kaas Q, Wehbi V, Ohresser M, Jefferis R, Lefranc M-P, Watier H (2007) Structure-function relationships of the variable domains of monoclonal antibodies approved for cancer treatment. Crit Rev Oncol Hematol 64:210–225
Pappalardo F, Lefranc M-P, Lollini P-L, Motta S (2010) A novel paradigm for cell and molecular interaction: from the CMM model to IMGT-ONTOLOGY. Immunome Res 6:1
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Lefranc, MP. (2013). IMGT-ONTOLOGY, FunctionType. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_665
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_665
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