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Clinical perspectives of cholecystokinin antagonists in pain management

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Regional Anaesthesia Analgesia and Pain Management

Part of the book series: Topics in Anaesthesia and Critical Care ((TIACC))

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Abstract

Cholecystokinin (CCK) is a peptide widely distributed in the central nervous system. Since its characterization in the porcine intestine, evidence has accumulated that it plays an essential role in several brain functions such as nociception, anxiety, memory, sleep and dopamine modulation. In mammalian brain, CCK is mainly found as an octapeptide (CCK-8) and tetrapeptide (CCK-4) and its effects are mediated by two types of receptors: CCK-A and CCK-B [1, 2]. CCK-8 acts at both receptors whereas CCK-4 shows its main activity at the CCK-B receptors. The distribution of the type-A and type-B receptors shows species differences and this fact has important clinical implications [3]. For example, CCKB binding sites are predominant in the spinal cord of rodents whereas CCK-A receptors prevail in the spinal cord of primates and humans. Therefore, the original nomenclature of peripheral alimentary (type A) and brain (type B) receptors no longer holds. It should be pointed out that, whereas the gene cckA encodes for the CCK-A receptor, the gene cckB encodes for both the CCK-B and gastrin receptor, thus indicating that the type-B binding site is better defined as CCK-B-gastrin receptor.

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Authors
  1. M. Amanzio
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  2. F. Benedetti
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Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    M. Tiengo MD (Professor Emeritus) (Professor Emeritus)

  2. Department of Anaesthesia, Intensive Care and Pain Therapy, University of Trieste, Cattinara Hospital, Trieste, Italy

    V. A. Paladini MD

  3. Department of Anaesthesiology and Intensive Care, Orebro University Hospital, Orebro, Sweden

    N. Rawal MD

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© 1999 Springer Verlag Italia, Milano

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Amanzio, M., Benedetti, F. (1999). Clinical perspectives of cholecystokinin antagonists in pain management. In: Tiengo, M., Paladini, V.A., Rawal, N. (eds) Regional Anaesthesia Analgesia and Pain Management. Topics in Anaesthesia and Critical Care. Springer, Milano. https://doi.org/10.1007/978-88-470-2240-9_10

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  • DOI: https://doi.org/10.1007/978-88-470-2240-9_10

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0044-5

  • Online ISBN: 978-88-470-2240-9

  • eBook Packages: Springer Book Archive

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