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New Cephalosporins: Fifth and Sixth Generations

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New Antimicrobials: For the Present and the Future

Part of the book series: Emerging Infectious Diseases of the 21st Century ((EIDC))

Abstract

New generation (5th) of cephalosporins have been introduced on the market over the last decade to combat methicillin-resistant Staphylococcus aureus (MRSA), i.e., ceftaroline and ceftobiprole, and avoid the toxicity of vancomycin. To meet the challenge of multiresistant Enterobacteriaceae and Pseudomonas infections, a novel siderophore cephalosporin (cefiderocol) was approved by the US Food and Drug Administration (FDA) for complicated urinary infections and pyelonephritis in 2019. This promising novel cephalosporin is active in vitro against most multiresistant and carbapenem-resistant gram-negative strains, even those resistant to all other antibiotics including colistin. Thus, it will be a useful agent to reserve for these difficult to treat pan-resistant gram-negative bacteria such as P. aeruginosa, A. baumannii, S. maltophilia, B. cepacia, and Serratia spp.

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  1. 4th Fl CC Wing North, Rm 4179, St. Michael’s Hospital, Toronto, ON, Canada

    I. W. Fong

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Fong, I.W. (2023). New Cephalosporins: Fifth and Sixth Generations. In: New Antimicrobials: For the Present and the Future. Emerging Infectious Diseases of the 21st Century. Springer, Cham. https://doi.org/10.1007/978-3-031-26078-0_2

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  • DOI: https://doi.org/10.1007/978-3-031-26078-0_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-26077-3

  • Online ISBN: 978-3-031-26078-0

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