Skip to main content

Perspectives into Genetic Manipulations for Control of Dengue Vector (Aedes aegypti Linnaeus, 1762) with Reference to Progress in Indian Experiments

  • Chapter
  • First Online:
Genetically Modified and other Innovative Vector Control Technologies

Abstract

Vector-borne diseases like malaria, dengue, chikungunya, Japanese encephalitis, Zika and others claim millions of lives across the globe annually, and as such their control has become an ardent necessity. Past attempts over the decades have introduced vector control through chemical, biological and environmental means. However, these measures, already in place, failed to completely bring down the mortality rates from vector-borne diseases, most of which lack a vaccine to prevent epidemics or even a specific antidote to treat patients. The modern development of technologies such as the release of insects carrying a dominant lethal (RIDL) gene system, an example of transgenesis; the Wolbachia-based cytoplasmic incompatibility inducing infertility in female insects, an example of paratransgenesis; and the revolutionary gene drive (CRISPR/Cas9) technology, has their roots in the sterile insect technology (SIT), which worked by creating sterilized males through irradiation to compete with their wild counterparts and subsequently mate with females in nature to produce infertile eggs; a technology meant to gradually and finally exterminate the vector population in nature. These technologies have shown great promise, albeit many imperfections, particularly regarding acceptance by the concerned societies. As far as vector control is concerned, we have attempted to simplify their definitions for the common man so that the intricate scientific jargon about these technologies do not instill any fear or doubts to the end users.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Carvalho DO, McKemey AR, Garziera L et al (2015) Suppression of a field population of Aedes aegypti in Brazil by sustained release of transgenic male mosquitoes. PLoS Negl Trop Dis 9(7):e0003864

    Article  Google Scholar 

  • Gould EA, Higgs S (2009) Impact of climate change and other factors on emerging arbovirus diseases. Trans R Soc Trop Med Hyg 103(2):109–121

    Article  CAS  Google Scholar 

  • Harris AF, McKemey AR, Nimmo D et al (2012) Successful suppression of a field mosquito population by sustained release of engineered male mosquitoes. Nat Biotechnol 30(9):828–830

    Article  CAS  Google Scholar 

  • Marshall JM (2010) The Cartagena protocol and genetically modified mosquitoes. Nat Biotechnol 28:896–897

    Article  CAS  Google Scholar 

  • Marshall JM (2011) The Cartagena protocol in the context of recent releases of transgenic and Wolbachia-infected mosquitoes. Asia Pac J Mol Biol Biotechnol 19:93–100

    Google Scholar 

  • Marshall JM, Akbari OS (2018) Can CRISPR-based gene drive be confined in the wild? A question for molecular and population biology. ACS Chem Biol 13:424–430

    Article  CAS  Google Scholar 

  • Patil PB, Niranjan Reddy BP, Gorman K et al (2015) Mating competitiveness and life-table comparisons between transgenic and Indian wild-type Aedes aegypti L. Pest Manag Sci 71(7):957–965

    Article  CAS  Google Scholar 

  • Patil PB, Gorman Kevin J, Dasgupta Shaibal K, Seshu Reddy KV, Barwale Shirish R, Zehr Usha B (2018) Self-limiting OX513A Aedes aegypti demonstrate full susceptibility to currently used insecticidal chemistries as compared to Indian wild-type Aedes aegypti. Psyche:7814643, 7 p. https://doi.org/10.1155/2018/7814643

  • Tyagi BK (2020) Mosquito hunters: a history of hostilities against man’s deadliest foe—the mosquito—since 1881. Scientific Publishers, Jodhpur, 474 pp

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Chatterjee, R., Bhattacharya, S., Tyagi, B.K. (2021). Perspectives into Genetic Manipulations for Control of Dengue Vector (Aedes aegypti Linnaeus, 1762) with Reference to Progress in Indian Experiments. In: Tyagi, B.K. (eds) Genetically Modified and other Innovative Vector Control Technologies. Springer, Singapore. https://doi.org/10.1007/978-981-16-2964-8_7

Download citation

Publish with us

Policies and ethics