Abstract
In Northern State, Sudan, a feasibility study for sterile insect technique (SIT) in an area-wide integrated pest management was established for the first time in an African country. The aim of the study was to see whether it is feasible, from a technical, an economical and a biological perspective, to use sterile male mosquitoes to control mosquito populations in designated areas in the African context. The project was focussed on Anopheles arabiensis, one of the major malaria vectors. Meteorological data, larval surveillance and population genetic studies were carried out on the disease vectors. The first phase of the study focussed on the development of an efficient sex-separation system, development of dose-sterility curves for the pupal and adult stages and testing of a range of doses in competition experiments to determine effective sterility dose. This stage was followed by a semi-field phase that monitored their swarming and mating behaviours, effectiveness of irradiated males in competitive experiments with wild males and insemination rates. Information regarding irradiation and transportation of irradiated males were also obtained during the study. Unfortunately, the SIT study was terminated in 2017 before starting field release of irradiated males. In spite of the challenges, such investment need not be totally abandoned as valuable experience has been gained and capacity built, which are of high value to malaria control program in Sudan.
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References
Ageep T, Damiens D, Alsharif B, Ahmed A, Salih E, Ahmed F, Diabaté A, Lees R, Gilles J, El Sayed B (2014) Participation of irradiated Anopheles arabiensis males in swarms following field release in Sudan. Malar J 13:484. http://www.malariajournal.com/content/13/1/484
Akpodiete N, Diabate A, Tripet F (2019) Effect of water source and feed regime on development and phenotypic quality in Anopheles gambiae (s.l.): prospects for improved mass-rearing techniques towards release programmes. Parasite Vector 12:210. https://doi.org/10.1186/s13071-019-3465-0
Ali B, Ageep T, Ahmed A, Salih E, Tagelsir F, El Sayed B (2018) Field evaluation of novel candidate traps for surveillance of mosquitoes in area for sterile insect technique trial in Sudan. Poster
Azrag R, Ibrahim K, Malcolm C, El Rayah E, El-Sayed B (2016) Laboratory rearing of Anopheles arabiensis: impact on genetic variability and implications for Sterile Insect Technique (SIT) based mosquito control in northern Sudan. Malar J 15:432. https://doi.org/10.1186/s12936-016-1484-2
Balfour A (1904) First report of the Welcome Tropical Research Laboratories at the Gordon Memorial College Department of Education. Gordon Medical College, Khartoum, p 12
Benedict M, Robinson A (2003) The first releases of transgenic mosquitoes: an argument for the sterile insect technique. Trends Parasitol 19:349–355
Catteruccia F, Benton J, Crisanti A (2005) An Anopheles transgenic sexing strain for vector control. Nat Biotechnol 23:1414–1417
Culbert N, Maiga H, Somda N, Gilles J, Bouyer J, Mamai W (2018) Longevity of mass-reared, irradiated and packed male Anopheles arabiensis and Aedes aegypti under simulated environmental field conditions. Parasite Vector 11:603. https://doi.org/10.1186/s13071-018-3191-z
Curtis C (1978) Genetic sex separation in Anopheles arabiensis and the production of sterile hybrids. Bull World Health Organ 56(3):453–454
Dame D, Lowe R, Williamson D (1981) Assessment of released sterile Anopheles albimanus and Glossina morsitans morsitans. In: Kitzmiller JB, Kanda T (eds) Cytogenetics and genetics of vectors. Elsevier Biomedical, New York, pp 231–248
Damiens D, Benedict M, Wille M, Gilles J (2012) An inexpensive and effective larval diet for Anopheles arabiensis (Diptera: Culicidae): eat like a horse, a bird, or a fish? J Med Entomol 49(5):1001–1011. https://doi.org/10.1603/ME11289
Damiens D, Vreysen M, Gilles J (2013) Anopheles arabiensis sperm production after genetic manipulation, dieldrin treatment, and irradiation. J Med Entomol 50(2):314–316. https://doi.org/10.1603/ME12058
El Gadal AA, Haridi AM, Hassan F, Hussein H (1985) Malaria control in the Gezira-Managil irrigated scheme of the Sudan. J Trop Med Hyg 88:153–159
El Sayed B, Malcolm C, Babiker A, Malik E, El Tayeb M, Saeed N, Nugud A, Knols B (2009) Ethical, legal and social aspects of the approach in Sudan. Malar J 8(Suppl. 2):S3. https://doi.org/10.1186/1475-2875-8-S2-S3
Grossman G, Rafferty C, Clayton J, Stevens T, Mukabayire O, Benedict M (2001) Germline transformation of the malaria vector, Anopheles gambiae, with the piggyBac transposable element. Insect Mol Biol 10:597–604
Gunathilaka N, Ranathunge T, Udayanga L, Wijegunawardena A, Gilles J, Abeyewickreme W (2019) Use of mechanical and behavioural methods to eliminate female Aedes aegypti and Aedes albopictus for sterile insect technique and incompatible insect technique applications. Parasit Vectors 12:148. https://doi.org/10.1186/s13071-019-3398-7
Haridi AM (1972) Partial exophily of Anopheles gambiae species B in Khashm Elgirba area in eastern Sudan. Bull World Health Organ 46:39–46
Hassan M, Zain H, Basheer M, Elhaj H, El-Sayed B (2014) Swarming and mating behavior of male Anopheles arabiensis Patton (Diptera: Culicidae) in an area of the Sterile Insect Technique Project in Dongola, northern Sudan. Acta Trop 132S:S64–S69
Helinski M, Knols B (2009) Sperm quantity and size variation in un-irradiated and irradiated males of the malaria mosquito Anopheles arabiensis Patton. Acta Trop 109:64–69
Helinski M, El-Sayed B, Knols B (2006a) The Sterile Insect Technique: can established technology beat malaria? Entomol Berichten 66(1):13–20
Helinski M, Parker A, Knols B (2006b) Radiation-induced sterility for pupal and adult stages of the malaria mosquito Anopheles arabiensis. Malar J 5:41. https://doi.org/10.1186/1475-2875-5-41
Helinski M, Hassan M, El-Motasim W, Malcolm C, Knols B, El-Sayed B (2008a) Towards a sterile insect technique field release of Anopheles arabiensis mosquitoes in Sudan: irradiation, transportation, and field cage experimentation. Malar J 7:65. https://doi.org/10.1186/1475-2875-7-65
Helinski M, Hood R, Knols B (2008b) A stable isotope dual-labelling approach to detect multiple insemination in un-irradiated and irradiated Anopheles arabiensis mosquitoes. Parasit Vectors 1:9. https://doi.org/10.1186/1756-3305-1-9
Ismail BA, Kafy HT, Suleiman JE, Subramaniam K, Thomas B, Kassim NF, Ahmad AH, Knox TB, Kleinschmidt I, Donelly MJ (2018) Temporal and spatial trends in insecticide resistance in Anopheles arabiensis in Sudan: outcomes from an evaluation of implications of insecticide for malaria vector control. Parasit Vectors 11:122
Klassen W, Curtis C (2005) History of the sterile insect technique. In: Dyck VA, Hendrichs J, Robinson AS (eds) Sterile insect technique: principles and practices in area-wide integrated pest management. Springer, Dordrecht, pp 39–68
Lees R, Gilles J, Hendrichs J, Vreysen M, Bourtzis K (2015) Back to the future: the sterile insect technique against mosquito disease vectors. Curr Opin Insect Sci 10:156–162
Lofgren C, Dame D, Breeland S, Weidhaas D, Jeffery G, Kaiser R, Ford H, Boston M, Baldwin K (1974) Release of chemosterilized males for the control of Anopheles albimanus in El Salvador III. Field methods and population control. Am J Trop Med Hyg 23:288–297
Malcolm C, Welsby D, El Sayed B (2007) SIT for malaria vector Anopheles arabiensis in northern state, Sudan: an historical review of the field site. In: Vreysen MJB, Robinson AS, Hendrichs J (eds) Area-wide control of insect pests. Springer, Dordrecht, pp 361–372
Malik EM, Ali E, Mohamed TA (2006) Efforts to control malaria in Sudan—case study of the National Malaria Control Programme, 2001–2005. SIMET 11:77–85
Mshinda H, Killeen G, Mukabana W, Mathenge E, Mboera L, Knols B (2004) Development of genetically modified mosquitoes in Africa. Lancet Infect Dis 4:264–265. http://infection.thelancet.com
Munhenga G, Brooke B, Chirwa T, Hunt R, Coetzee M, Govender D, Koekemoer L (2011) Evaluating the potential of the sterile insect technique for malaria control: relative fitness and mating compatibility between laboratory colonized and a wild population of Anopheles arabiensis from the Kruger National Park, South Africa. Parasit Vectors 4:208. http://www.parasitesandvectors.com/content/4/1/208
Munhenga G, Brooke B, Gilles J, Slabbert K, Kemp A, Dandalo L, Wood O, Lobb L, Govender D, Renke M, Koekemoer L (2016) Mating competitiveness of sterile genetic sexing strain males (GAMA) under laboratory and semi-field conditions: steps towards the use of the Sterile Insect Technique to control the major malaria vector Anopheles arabiensis in South Africa. Parasit Vectors 9:122. https://doi.org/10.1186/s13071-016-1385-9
Oliva C, Benedict M, Soliban S, Lemperiere G, Balestrino F, Gilles J (2012) Comparisons of life-history characteristics of a genetic sexing strain with laboratory strains of Anopheles arabiensis (Diptera: Culicidae) from northern Sudan. J Med Entomol 49(5):1045–1051. https://doi.org/10.1603/ME11292
Poda S, Guissou E, Maïga H, Bimbile-Somda S, Gilles J, Rayaisse J, Lefèvre T, Roux O, Dabiré R (2018) Impact of irradiation on the reproductive traits of field and laboratory An. arabiensis mosquitoes. Parasit Vectors 11:641. https://doi.org/10.1186/s13071-018-3228-3
Robinson A, Knols B, Voigt G, Hendrichs J (2009) Conceptual framework and rationale. Malar J 8(Suppl 2):S1. https://doi.org/10.1186/1475-2875-8-S2-S1
Scolari F, Siciliano P, Gomulski P, Bonomi A, Malacrida G (2010) Safe and fit genetically modified insects for pest control: from lab to field applications. Genetica. https://doi.org/10.1007/s10709-010-9483-7
Touré Y, Dolo G, Petrarca V, Traoré S, Bouaré M, Dao A, Carnahan J, Taylor C (1998) Mark–release–recapture experiments with Anopheles gambiae s.l. in Banambani Village, Mali, to determine population size and structure. Med Vet Entomol 12:74–83
Urquidi J, Brar R, Rodriguez S, Hansen I (2015) The development of new radiation protocols for insect sterilization using long wavelength X-rays. Radiat Phys AIP Conf Proc 1671:020010-1–020010-7. https://doi.org/10.1063/1.4927187
Vreysen M (1995) Radiation induced sterility to control Tsetse flies. PhD thesis, Wageningen Agricultural University
White G (1974) Anopheles gambiae complex and disease transmission in Africa. Trans Roy Soc Trop Med Hyg 68:278–301
WHO (2020) World malaria report: 20 years of global progress and challenges. World Health Organization, Geneva. ISBN: 978-92-4-001579-1. https://www.who.int/publications/i/item/9789240015791
Wilke A, Nimmo D, John O, Kojin B, Capurro M, Marrelli M (2009) Mini-review: genetic enhancements to the sterile insect technique to control mosquito populations. Asia Pac J Mol Biol Biotechnol 17(3):65–74
Yamada H, Benedict M, Malcolm C, Oliva C, Soliban S, Gilles J (2012) Genetic sex separation of the malaria vector, Anopheles arabiensis, by exposing eggs to dieldrin. Malar J 11:208–219. https://doi.org/10.1186/1475-2875-11-208
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Elaagip, A., Adedapo, A. (2021). Three Decades of Malaria Vector Control in Sudan: The Plausible Role of Sterile Insect Technique (SIT). In: Tyagi, B.K. (eds) Genetically Modified and other Innovative Vector Control Technologies. Springer, Singapore. https://doi.org/10.1007/978-981-16-2964-8_6
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