Inflammation Research
Volume 1 / 1969 - Volume 66 / 2017
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395,198 Result(s)
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Journal
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Clinical Drug Investigation
Volume 1 / 1989 - Volume 37 / 2017
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Pharmaceutical Research
Volume 1 / 1984 - Volume 34 / 2017
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Naunyn-Schmiedeberg's Archives of Pharmacology
Volume 1 / 1873 - Volume 390 / 2017
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Article
Patterns, predictors and persistence of chronic sedative use: a population-based observational study of older adults in British Columbia, Canada
Benzodiazepines and benzodiazepine-like sedatives (zopiclone, zolpidem and zaleplon) are commonly prescribed to treat anxiety and insomnia but are contraindicated for chronic use. We sought to study the persis...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Economic Evaluation of Tobramycin Inhalation Powder for the Treatment of Chronic Pulmonary Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis
Chronic lung infection with Pseudomonas aeruginosa occurs in approximately 50% of patients with cystic fibrosis (CF). This infection further compromises lung function, and significantly contributes to the increas...
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Article
Clincal interpretation of the anti-tuberculosis drug concentrations in diabetic and non-diabetic tuberculosis patients
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Article
Decrease in Switches to ‘Unsafe’ Proton Pump Inhibitors After Communications About Interactions with Clopidogrel
In 2009 and 2010 medicines regulatory agencies published official safety statements regarding the concomitant use of proton pump inhibitors and clopidogrel. We wanted to investigate a change in prescription be...
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Article
Hepatic Uptake Mechanism of Ophiopogonin D Mediated by Organic Anion Transporting Polypeptides
Ophiopogonin D (OPD) is one of the main active ingredients of SMI (Shenmai injection) which is widely used in clinical practice in China. Our previous study indicated that OPD might be transported from blood ...
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Article
Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage
Roflumilast, a selective inhibitor for PDE4, is approved by FDA as an anti-inflammation drug for treatment of chronic obstructive pulmonary disease (COPD). This study investigates the effects of roflumilast on...
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Article
Revised editorial guidelines for manuscripts on the pharmacology of plant extracts
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Article
A Critical Role for IL-21 Receptor Signaling in the Coxsackievirus B3-Induced Myocarditis
To determine whether IL-21 receptor signaling plays a significant role in promoting Tfh cell-mediated cardiac injury in viral myocarditis (VMC), we compared IL-21R-deficient mice for some parameters of VMC. Ba...
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Article
Development and Validation of a Novel Questionnaire for Adherence with Topical Treatments in Psoriasis (QATOP)
Self-report measures are the most used methodologies for the evaluation of adherence to psoriasis topical treatment, although currently there is no standard questionnaire for this purpose.
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Article
Preemptive Panel-Based Pharmacogenetic Testing: The Time is Now
While recent discoveries have paved the way for the use of genotype-guided prescribing in some clinical environments, significant debate persists among clinicians and researchers about the optimal approach to ...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus
Callisalignenes G–I (1–3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations ...
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Article
Diclofenac sex-divergent drug-drug interaction with Sunitinib: pharmacokinetics and tissue distribution in male and female mice
Coadministration of diclofenac and sunitinib, tyrosine kinase inhibitor, led to sex-divergent pharmacokinetic drug-drug interaction outcomes. Male and female mice were administered 60 mg/kg PO sunitinib alone ...
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Article
CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure
This study examined whether a CYP2D6 polymorphism (CYP2D6*4) was related to beta-blocker maintenance dose in patients with heart failure.
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Article
A dosing algorithm for metformin based on the relationships between exposure and renal clearance of metformin in patients with varying degrees of kidney function
The aims of this study were to investigate the relationship between metformin exposure, renal clearance (CLR), and apparent non-renal clearance of metformin (CLNR/F) in patients with varying degrees of kidney fun...
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Article
Anti-inflammatory Effects of Valproic Acid in a Rat Model of Renal Ischemia/Reperfusion Injury: Alteration in Cytokine Profile
Valporic acid (VPA) has been implicated to have anti-inflammatory and anti-oxidant activities in several ischemic/reperfusion (I/R) injury models. This study intended to evaluate whether VPA could affect the i...
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Article
Management of Heart Failure with Preserved Ejection Fraction: Current Challenges and Future Directions
Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF in patients older than 65 years. Among elderly women living in the community, HFpEF comprises nearly 90% of incident HF...
