98,660 Result(s)
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Article
Does spinal excitability scale to the difficulty of the dual-task?
This study examined whether spinal excitability, as measured by the soleus Hoffmann reflex (H-reflex), is scaled to the difficulty level of the dual-task being performed.
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation
Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secr...
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Article
Hepatic Uptake Mechanism of Ophiopogonin D Mediated by Organic Anion Transporting Polypeptides
Ophiopogonin D (OPD) is one of the main active ingredients of SMI (Shenmai injection) which is widely used in clinical practice in China. Our previous study indicated that OPD might be transported from blood ...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Movement amplitude on the Functional Re-adaptive Exercise Device: deep spinal muscle activity and movement control
Lumbar multifidus (LM) and transversus abdominis (TrA) show altered motor control, and LM is atrophied, in people with low-back pain (LBP). The Functional Re-adaptive Exercise Device (FRED) involves cyclical l...
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Article
Perioperative hypothalamic pituitary adrenal function in patients with silent corticotroph adenomas
Silent corticotroph adenomas (SCAs) are characterized by strong ACTH immunostaining without clinical manifestations of hypercortisolism. Patients with SCAs often present with mechanical symptoms related to tum...
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Article
Estimation of respiratory volume from thoracoabdominal breathing distances: comparison of two models of machine learning
The purposes of this study were to both improve the accuracy of respiratory volume (V) estimates using the respiratory magnetometer plethysmography (RMP) technique and facilitate the use of this technique.
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
T-regulatory cells exhibit a biphasic response to prolonged endurance exercise in humans
T-regulatory cells (Tregs) are a sub-population of lymphocytes that act to suppress aberrant immune responses. We investigated changes in the numbers of naïve and terminally differentiated Tregs in the periphe...
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Article
The longest stalk: preserved pituitary function after regression of a giant prolactinoma
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Article
Bed rest and resistive vibration exercise unveil novel links between skeletal muscle mitochondrial function and insulin resistance
Physical inactivity has broad implications for human disease including insulin resistance, sarcopenia and obesity. The present study tested the hypothesis that (1) impaired mitochondrial respiration is linked ...
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Article
The influence of vitamin C on the interaction between acute mental stress and endothelial function
To determine whether orally administered vitamin C attenuates expected mental stress-induced reductions in brachial artery endothelial function as measured by flow-mediated dilation (FMD).
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Effects of semaglutide on beta cell function and glycaemic control in participants with type 2 diabetes: a randomised, double-blind, placebo-controlled trial
Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glyc...
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Article
Pharmacokinetic Drug Interactions with Panax ginseng
Panax ginseng is widely used as an adaptogen throughout the world. The major active constituents of P. ginseng are ginsenosides. Most naturally occurring ginsenosides are deglycosylated b...
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Article
SGLT2 inhibitors and diabetic ketoacidosis: data from the FDA Adverse Event Reporting System
Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are indicated for the treatment of type 2 diabetes and may also improve glucose control in type 1 diabetes. In 2015, regulatory agencies warned that SGLT2i m...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Retinal oxygen extraction in individuals with type 1 diabetes with no or mild diabetic retinopathy
The aim of this study was to compare retinal oxygen extraction in individuals with diabetes with no or mild non-proliferative diabetic retinopathy and healthy age- and sex-matched volunteers.
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Article
Mixed Micelles Loaded with Bile Salt: An Approach to Enhance Intestinal Transport of the BCS Class III Drug Cefotaxime in Rats
Cefotaxime is a class III drug according to the Biopharmaceutical Classification System due to low intestinal permeability based on poor oral bioavailability. Bile salt compounds have been shown to be effectiv...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Antibodies to post-translationally modified insulin as a novel biomarker for prediction of type 1 diabetes in children
We have shown that autoimmunity to insulin in type 1 diabetes may result from neoepitopes induced by oxidative post-translational modifications (oxPTM). Antibodies specific to oxPTM-insulin (oxPTM-INS-Ab) are ...
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Article
Absorption, Distribution, Metabolism, and Excretion of the Androgen Receptor Inhibitor Enzalutamide in Rats and Dogs
Enzalutamide is an androgen receptor inhibitor that has been approved in several countries. Absorption, distribution, metabolism, and excretion (ADME) data in animals would facilitate understanding of the effi...
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Article
Novel Antiretroviral Drugs in Patients with Renal Impairment: Clinical and Pharmacokinetic Considerations
Highly active antiretroviral therapy (HAART) has dramatically increased the survival of HIV-infected patients from Western countries reducing the incidence of opportunistic infections and AIDS-related malignan...
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Article
Erratum to: Exercise increases lactoferrin, but decreases lysozyme in salivary granulocytes
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
The effects of strength training versus ski-ergometer training on double-poling capacity of elite junior cross-country skiers
To compare the effects of strength training versus ski-ergometer training on double-poling gross efficiency (GE), maximal speed (V max), peak oxygen uptake (
