28 Result(s)
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Article
Poster abstracts
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Chapter and Conference Paper
Nitric Oxide
Over the last ten years or so, a role of NO in sepsis and MOF has been established. A number of studies have been performed in animals and in patients in which the generation of NO in sepsis has been pharmacol...
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Chapter
Nitric Oxide and the Vascular Endothelium
The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric oxide (NO) from L-arginine. This action is catalysed by the action of NO synthases, of which two forms are present in the ...
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Article
Synergistic action of advanced glycation end products and endogenous nitric oxide leads to neuronal apoptosis in vitro: A new insight into selective nitrergic neuropathy in diabetes
We have previously shown that in diabetes nitrergic neurones innervating the urogenital and gastrointestinal organs undergo a selective degenerative process. This comprises an initial insulin-reversible decrea...
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Chapter
Introduction
It gives me great pleasure to write the Introduction to this book on nitric oxide (NO). Many thanks are due to Bernd Mayer, who approached me over a year ago with a request to give an overview of the discovery...
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Chapter
Therapeutic Potential of NOS Inhibitors in Septic Shock
Septic shock is a syndrome characterised by vascular collapse presumed to be initiated by infection. It is the most common cause of death in intensive care units and is associated with an overall mortality rat...
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Chapter and Conference Paper
Nitric Oxide and Hypertension: Physiology and Pathophysiology
The field of nitric oxide (NO) research has progressed rapidly and yielded many unexpected insights into cardiovascular control. In 1980 the phenomenon of endothelium-dependent relaxation and the existence of ...
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Article
Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog,Rana temporaria
Physiological and histochemical studies have recently supported the notion that nitric oxide (NO) is the transduction signal responsible for the non-adrenergic, non-cholinergic relaxation of the vasculature as...
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Article
Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria
Physiological and histochemical studies have recently supported the notion that nitric oxide (NO) is the transduction signal responsible for the non-adrenergic, non-cholinergic relaxation of the vasculature as...
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Article
Nitric oxide (NO) synthase immunoreactivity in the starfish Marthasterias glacialis
The neuroendocrine system of the starfish Marthasterias glacialis was investigated immunocytochemically using antisera specific for rat neuronal, bovine aortic endothelial, and mouse macrophage, nitric oxide (NO)...
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Article
Induction of nitric oxide synthase in rat intestine and its association with tissue injury
Induction of a calcium-independent nitric oxide synthase (NOS) has been detected in the rat small intestine and colon, 3–5 h following endotoxin (3 mg kg−1 i.v.). This was associated with an increase in vascular ...
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Chapter
Bradykinin Stimulates L-Arginine Transport and Nitric Oxide Release in Vascular Endothelial Cells
Vascular endothelial cells synthesize nitric oxide (NO) from the terminal guanidine-nitrogen atom of the cationic amino acid L-arginine (Palmer, R et al, 1988). Although basal NO synthesis is not limited by argin...
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Article
Immunological detection of nitric oxide synthase(s) in human tissues using heterologous antibodies suggesting different isoforms
Nitric oxide (NO) is generated from l-arginine by NO synthases. Localization of the brain enzyme has been carried out in the rat; however, despite data suggesting that NO is a major regulator of vascular and neur...
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Chapter
The L-Arginine: Nitric Oxide Pathway in Physiology and Pathology
The demonstration that vascular endothelial cells form nitric oxide (NO) from the amino acid L-arginine has led to the discovery that this molecule not only explains the biological properties of the so-called end...
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Chapter
Role of Nitric Oxide in Endothelial Cell - Platelet Interactions
Nitric oxide (NO) is synthesized by constitutive and inducible NO synthases. The formation of NO by the constitutive enzyme and subsequent stimulation of the soluble guanylate cyclase in the vascular system is...
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Chapter
Endothelium-Derived Vasodilators
The importance of the endothelium in vessel wall homeostasis has recently become apparent. The vascular endothelium has been discovered to generate two potent vasodilators, prostacyclin (Moncada et al., 1976) and...
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Article
Synthesis of eicosanoids by tissues of the synovial joint during the development of chronic erosive synovitis
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Article
Leukotrienes in Disease
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Article
The anti-inflammatory effect of glucocorticoid-induced phospholipase inhibitory proteins
The anti-inflammatory effect of glucocorticoids has been investigated in two standard models of experimental inflammation, i.e. rat paw oedema induced by carrageenin or dextran.
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Chapter
The Synthesis and Inhibition of Eicosanoids in Inflammation
The interest of pharmacologists and physiologists in biologically active lipids has led to the discovery of two important families of mediators, the prostaglandins and the leukotrienes. Both these groups of co...
