24 Result(s)
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Article
MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status
MicroRNAs are single-stranded small non-coding RNA molecules which regulate mammalian cell growth, differentiation, and apoptosis by altering the expression of other genes and play a role in tumor genesis and ...
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Chapter
Dual electrode spinal cord stimulation in chronic leg and back pain
Patients with chronic back and leg pain (CBLP) suffer from a disabling spinal condition of multifactorial origin and are often resistant to medical therapy. Spinal cord stimulation (SCS) is a minimally invasiv...
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Chapter
Hardware failures in spinal cord stimulation (SCS) for chronic benign pain of spinal origin
Spinal cord stimulation (SCS) has become an established clinical option for treatment of refractory chronic pain not related to cancer. Current hardware and implantation techniques for SCS are already highly d...
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Chapter
Experimental therapies for chronic pain
Chronic pain, an underestimated but complex medical and social phenomenon, is often resistant to currently used analgesic drugs. The effect of these substances is frequently self-limiting, with increasing leve...
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Chapter
Management of chronic back and leg pain by intrathecal drug delivery
Intrathecal delivery of analgesic drugs by implantable pump systems has been recognized as a treatment option for patients with chronic pain of benign or malignant origin that is resistant to oral or parentera...
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Chapter and Conference Paper
Treatment Options in Patients with Prion Disease - the Role of Long Term Cerebroventricular Infusion of Pentosan Polysulphate
Prion diseases (PrD), also known as transmissible spongiform encephalopathies, are believed to be caused by accumulation of an abnormal isoform of the prion protein (PrPSC) in the central nervous system. Creutzfe...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivoimaging of gene therapy in malignant glioma
Suicide gene therapy employing the prodrug activating system Herpes simplex virus type 1 thymidine kinase (HSV-TK)/ ganciclovir (GCV) has proven to be effective in killing experimental brain tumors. In contras...
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Article
Clinical Trials with Retrovirus Mediated Gene Therapy – what Have we Learned?
Retrovirus (RV) has been one of the earliest recombinant vectors to be investigated in the context of cancer gene therapy. Experiments in cell culture and in animal brain tumor models have demonstrated the fea...
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Article
Safety, Tolerability, and Tumor Response of IL4-Pseudomonas Exotoxin (NBI-3001) in Patients with Recurrent Malignant Glioma
Purpose: This was an open-label, dose-escalation trial of intratumoral administration of IL-4 Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma.
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Article
Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma
Purpose: This was an open-label, dose-escalation trial of intratumoral administration of IL-4Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma.
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Article
Verletzungen des okzipito-zervikalen Übergangs und des Atlas
Die obere Wirbelsäule, bestehend aus dem okzipito-zervikalen Übergang und dem atlanto-axialen Komplex, ist ein Übergangsbereich, der die Wirbelsäule mit dem Kranium verbindet. Wirbel und Gelenke unterscheiden ...
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Protocol
Experimental Strategies for Combined Suicide and Immune Cancer Gene Therapy
Suicide gene therapy systems are characterized by the transfer of therapeutic transgenes, which encode for enzymes of various origins. These enzymes are able to convert nontoxic prodrugs into highly cytotoxic ...
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Article
Traumatische Schäden am Rückenmark
Zusammenfassung
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Article
Brain Glioma and Human Leukocyte Antigens (HLA) – is There an Association
Expression of human leukocyte antigens (HLA) is important for the immune response against infectious agents and malignant cells. Association of single HLA antigens or HLA haplotypes with disease has been inves...
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Article
Bcl-2 Expression in Higher-grade Human Glioma: A Clinical and Experimental Study
Bcl-2 protein plays an important role in inhibiting apoptosis and protecting normal and neoplastic cells from toxicity. Bcl-2 overexpression in malignant tumors, on the other hand, may cause resistance against...
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Article
Improved method for transport of living cell cultures
An easy and cost-effective method for transport of living cell cultures which avoids the use of dry ice and prevents bacterial contamination is described. Cells are suspended in buffered culture medium in seal...
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Chapter
A Chimeric Fusion Protein of Cytochrome CYP4B1 and Green Fluorescent Protein for Detection of Pro-Drug Activating Gene Delivery and for Gene Therapy in Malignant Glioma
Quantity and distribution of transgene-expressing tumor cells are central issues in cancer gene therapy. These are critical for the efficiency of tumor killing and for the bystander effect. In an attempt to co...
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Article
Prognostic factors in malignant glioma: Influence of the overexpression of oncogene and tumor-suppressor gene products on survival
Despite the use of multimodal therapy, higher-grade glioma is stilluniformly fatal in the adult population. There is a considerable differencebetween the length of survival in each given patient, even within t...
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Article
Factors predicting pituitary adenoma invasiveness in acromegalic patients
Forty-four adult acromegalic patients carrying growth hormone-producing pituitary macroadenomas were investigated with neuroradiological and endocrinological techniques. Plasma growth hormone and somatomedin-C...
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Article
Local invasivity of glioblastoma multiforme with destruction of skull bone. Case report and review of the literature
Primary tumors originating from cells of the glial lineage usually affect predominantly the white matter of the brain. Only rarely do gliomas destroy the surrounding bone by invasion of the extracellular matri...
