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34 Result(s)
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Quantitative evaluation and reversion analysis of the attractor landscapes of an intracellular regulatory network for colorectal cancer
Cancer reversion, converting the phenotypes of a cancer cell into those of a normal cell, has been sporadically observed throughout history. However, no systematic analysis has been attempted so far.
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Attractor landscape analysis of colorectal tumorigenesis and its reversion
Colorectal cancer arises from the accumulation of genetic mutations that induce dysfunction of intracellular signaling. However, the underlying mechanism of colorectal tumorigenesis driven by genetic mutations...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
An efficient algorithm for identifying primary phenotype attractors of a large-scale Boolean network
Boolean network modeling has been widely used to model large-scale biomolecular regulatory networks as it can describe the essential dynamical characteristics of complicated networks in a relatively simple way...
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Article
Discriminating between explosions and earthquakes
Earthquake, explosion, and a nuclear test data are compared with forward modeling and band-pass filtered surface wave amplitude data for exploring methodologies to improve earthquake-explosion discrimination. ...
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Article
Layer- and cell-type-specific tonic GABAergic inhibition of pyramidal neurons in the rat visual cortex
Tonic inhibition mediated by persistent activation of γ-aminobutyric acidA (GABAA) receptors by ambient GABA plays a crucial role in the regulation of network excitability and neuronal signal processing. Varying ...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Impaired coupling of local and global functional feedbacks underlies abnormal synchronization and negative symptoms of schizophrenia
Abnormal synchronization of brain oscillations is found to be associated with various core symptoms of schizophrenia. However, the underlying mechanism of this association remains yet to be elucidated.
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Book and Reference Work
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
A checkpoints capturing timing-robust Boolean model of the budding yeast cell cycle regulatory network
Cell cycle process of budding yeast (Saccharomyces cerevisiae) consists of four phases: G1, S, G2 and M. Initiated by stimulation of the G1 phase, cell cycle returns to the G1 stationary phase through a sequence ...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Computational modeling of apoptotic signaling pathways induced by cisplatin
Apoptosis is an essential property of all higher organisms that involves extremely complex signaling pathways. Mathematical modeling provides a rigorous integrative approach for analyzing and understanding suc...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in Drosophila melanogaster
Network motifs provided a “conceptual tool” for understanding the functional principles of biological networks, but such motifs have primarily been used to consider static network structures. Static networks, ...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
An optimally evolved connective ratio of neural networks that maximizes the occurrence of synchronized bursting behavior
Synchronized bursting activity (SBA) is a remarkable dynamical behavior in both ex vivo and in vivo neural networks. Investigations of the underlying structural characteristics associated with SBA are crucial to ...
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Chapter
Load-Balanced Handover with Adaptive Hysteresis in a Femto-Cell System
Recently mobile communication systems such as 3GPP LTE, IEEE802.16e have been growing interest in the femto-cell systems for increase of data rates and enhanced call quality. In a femto-cell system, frequent h...
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Chapter and Conference Paper
Load-Balanced Handover Based on Adaptive Hysteresis in a Femto-Cell System
Recently mobile communication systems such as 3GPP LTE, IEEE802.16e have been growing interest in the femto-cell systems for increase of data rates and enhanced call quality. In a femto-cell system, frequent h...
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Article
Crustal Structure of the Korean Peninsula Using Surface Wave Dispersion and Numerical Modeling
Surface wave dispersion is studied to obtain the 1-D average velocity structure of the crust in the Korean Peninsula by inverting group- and phase-velocities jointly. Group velocities of short-period Rayleigh ...
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Article
Crust and upper mantle structures of the region between Korea and Taiwan by surface wave dispersion study
We have investigated the crust and upper-mantle shear velocity structures of the region between Korea and Taiwan by analyzing the path-averaged group-velocity dispersion characteristic curves derived from surf...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
The Ninth Asia Pacific Bioinformatics Conference (APBC2011)
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Chapter and Conference Paper
Adaptive Cell Management in a Femto-Cell System
Recently mobile communication systems such as 3GPP LTE, IEEE802.16e have been growing interest in the femto-cell systems for increase of data rates and enhanced call quality. Cell management method for handove...
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Article
Identification of feedback loops embedded in cellular circuits by investigating non-causal impulse response components
Feedback circuits are crucial dynamic motifs which occur in many biomolecular regulatory networks. They play a pivotal role in the regulation and control of many important cellular processes such as gene trans...
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Article
Dermal fibrosis in male pattern hair loss: a suggestive implication of mast cells
A relationship has been suggested between mast cells (MCs) and male pattern hair loss (MPHL), because of histological evidence of perifollicular fibrosis and increased mast cell numbers. Two paired punch biops...
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Chapter
Cardiac Systems Biology and Parameter Sensitivity Analysis: Intracellular Ca2+ Regulatory Mechanisms in Mouse Ventricular Myocytes
Intracellular Ca2+ dynamics of cardiac myocytes are regulated by complexmechanisms of a variety of ion channels, transporters, and exchangers. Alterations of these Ca2+regulatory components might lead to developm...
