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24 Result(s)
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Article
Transient modulation of calcium and parathyroid hormone stimulates bone formation
Intermittent administration of parathyroid hormone can stimulate bone formation. Parathyroid hormone is a natural hormone that responds to serum calcium levels. In this study, we examined whether a transient i...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Stimulation of osteoblast differentiation with guided ultrasound waves
Ultrasound induces mechanical vibration and heat, causing differentiation and proliferation in osteoblasts. All known in vitro evaluations of ultrasound are, however, performed with longitudinal ultrasound waves....
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Article
Resonance in the mouse tibia as a predictor of frequencies and locations of loading-induced bone formation
To enhance new bone formation for the treating of patients with osteopenia and osteoporosis, various mechanical loading regimens have been developed. Although a wide spectrum of loading frequencies is proposed...
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Article
Suppression of osteoclastogenesis through phosphorylation of eukaryotic translation initiation factor 2 alpha
In response to various stresses including viral infection, nutrient deprivation, and stress to the endoplasmic reticulum, eukaryotic translation initiation factor 2 alpha (eIF2α) is phosphorylated to cope with...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Knee loading reduces MMP13 activity in the mouse cartilage
Moderate loads with knee loading enhance bone formation, but its effects on the maintenance of the knee are not well understood. In this study, we examined the effects of knee loading on the activity of matrix...
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Article
RhoA GTPase interacts with beta-catenin signaling in clinorotated osteoblasts
Bone is a dynamic tissue under constant remodeling in response to various signals including mechanical loading. A lack of proper mechanical loading induces disuse osteoporosis that reduces bone mass and struct...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells
Osteoporosis is a skeletal disease leading to an increased risk of bone fracture. Using a mouse osteoporosis model induced by administration of a receptor activator of nuclear factor kappa-B ligand (RANKL), sa...
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Book and Reference Work
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Article
Salubrinal promotes healing of surgical wounds in rat femurs
Phosphorylation of eukaryotic initiation factor 2α (eIF2α), transiently activated by various cellular stresses, is known to alleviate stress-induced cellular damage. Here, we addressed a question: does elevati...
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Article
Hydroxyapatite Modulates mRNA Expression Profiles in Cultured Osteocytes
Osteocytes in vivo present a unique pattern of gene expression necessary for bone remodeling and mineral metabolism. Genes expressed in osteocytes such as Sost and fibroblast growth factor 23 (FGF23) are essentia...
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Article
Elbow loading promotes longitudinal bone growth of the ulna and the humerus
Mechanical stimulation plays a critical role in bone development and growth. In view of recently recognized anabolic responses promoted by a joint-loading modality, we examined the effects of elbow loading on ...
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Article
Mechanical Loading: Bone Remodeling and Cartilage Maintenance
Bone remodeling and cartilage maintenance are strongly influenced by biomechanical signals generated by mechanical loading. Although moderate loading is required to maintain bone mass and cartilage homeostasis...
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Article
Lengthening of mouse hindlimbs with joint loading
For devising clinical approaches to treating limb length discrepancies, strategies that will generate differential longitudinal growth need to be improved. This report addresses the following question: does kn...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Evaluation of a pig femoral head osteonecrosis model
A major cause of osteonecrosis of the femoral head is interruption of a blood supply to the proximal femur. In order to evaluate blood circulation and pathogenetic alterations, a pig femoral head osteonecrosis...
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Article
Microarray analysis of thapsigargin — induced stress to the endoplasmic reticulum of mouse osteoblasts
Activating transcription factor 4 (ATF4) protein has a dual role in osteoblasts. It functions as a responder to stress to the endoplasmic reticulum (ER) as well as a transcription factor for bone formation. Li...
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Article
Frequency-dependent enhancement of bone formation in murine tibiae and femora with knee loading
Knee loading is a relatively new loading modality in which dynamic loads are laterally applied to the knee to induce bone formation in the tibia and the femur. The specific aim of the current study was to eval...
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Article
Knee-Loading Modality Drives Molecular Transport in Mouse Femur
Mechanical loading is well known to stimulate bone remodeling. Load-driven interstitial fluid flow and molecular transport have been postulated to play a role in the enhancement of bone formation. In order to ...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Knee loading stimulates cortical bone formation in murine femurs
Bone alters its architecture and mass in response to the mechanical environment, and thus varying loading modalities have been examined for studying load-driven bone formation. The current study aimed to evalu...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Artificial ants deposit pheromone to search for regulatory DNA elements
Identification of transcription-factor binding motifs (DNA sequences) can be formulated as a combinatorial problem, where an efficient algorithm is indispensable to predict the role of multiple binding motifs....
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Principal component analysis for predicting transcription-factor binding motifs from array-derived data
The responses to interleukin 1 (IL-1) in human chondrocytes constitute a complex regulatory mechanism, where multiple transcription factors interact combinatorially to transcription-factor binding motifs (TFBM...
