4 Result(s)
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Chapter
Nitric Oxide and the Vascular Endothelium
The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric oxide (NO) from L-arginine. This action is catalysed by the action of NO synthases, of which two forms are present in the ...
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Chapter
Nitric Oxide in the Cardiovascular System
Between 1987 and 1988, we found that vascular endothelial cells generate nitric oxide (NO) from the amino acid L-arginine. The formation of NO by this L-arginine: NO pathway was subsequently found to occur in ...
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Chapter
The L-Arginine: Nitric Oxide Pathway in Physiology and Pathology
The demonstration that vascular endothelial cells form nitric oxide (NO) from the amino acid L-arginine has led to the discovery that this molecule not only explains the biological properties of the so-called end...
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Chapter
Endothelium-Derived Vasodilators
The importance of the endothelium in vessel wall homeostasis has recently become apparent. The vascular endothelium has been discovered to generate two potent vasodilators, prostacyclin (Moncada et al., 1976) and...
