40 Result(s)
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Article
Parasympathetic cardio-regulation during social interactions in individuals with obesity—The influence of negative body image
Individuals with obesity in Western societies often face weight-related stigmatization and social exclusion. Recurrent exposure to prejudice and negative social feedback alters one’s behavior in future social ...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Outcomes of stable and unstable patterns of subjective cognitive decline – results from the Leipzig Longitudinal Study of the Aged (LEILA75+)
Subjective cognitive decline (SCD), i.e., the self-perceived feeling of worsening cognitive function, may be the first notable syndrome of preclinical Alzheimer’s disease and other dementias. However, not all ...
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Article
Feasibility and acceptance of simultaneous amyloid PET/MRI
Established Alzheimer’s disease (AD) biomarker concepts classify into amyloid pathology and neuronal injury biomarkers, while recent alternative concepts classify into diagnostic and progression AD biomarkers....
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Article
Das Kompetenznetz Schlaganfall
Kompetenznetze in der Medizin sind ab 1999 vom Bundesministerium für Bildung und Forschung initiiert worden, mit dem Ziel, Forschungspotenziale zu bestimmten Krankheitsbildern, die durch eine hohe Morbidität o...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany
The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, a major city with 550,000 inhabitants in th...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Genetic variants in AKR1B10 associate with human eating behavior
The human Aldoketoreductase 1B10 gene (AKR1B10) encodes one of the enzymes belonging to the family of aldoketoreductases and may be involved in detoxification of nutrients during digestion. Further, AKR1B10 mRNA ...
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Article
Identifying neural correlates of memory and language disturbances in herpes simplex encephalitis: a voxel-based morphometry (VBM) study
Herpes simplex encephalitis (HSE) is a severe neurological disease that often leads to persistent cognitive deficits in survivors. Memory and naming impairments have been reported most, although direct associa...
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Chapter and Conference Paper
The Path from Obesity and Hypertension to Dementia
Hypertension and obesity are two major risk factors for the development of vascular diseases such as coronary artery disease or stroke. Traditionally, it has been assumed that neurodegenerative disorders such ...
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Article
Role of genetic variants in ADIPOQ in human eating behavior
The beneficial effects of adiponectin and its negative correlation with BMI are well described. Adiponectin serum levels are altered in eating disorders such as anorexia nervosa, bulimia nervosa or binge eati...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Association between mental demands at work and cognitive functioning in the general population – results of the health study of the Leipzig research center for civilization diseases (LIFE)
The level of mental demands in the workplace is rising. The present study investigated whether and how mental demands at work are associated with cognitive functioning in the general population.
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Alexithymia and the labeling of facial emotions: response slowing and increased motor and somatosensory processing
Alexithymia is a personality trait that is characterized by difficulties in identifying and describing feelings. Previous studies have shown that alexithymia is related to problems in recognizing others’ emoti...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Patient-reported outcomes in adequately treated hypothyroidism – insights from the German versions of ThyDQoL, ThySRQ and ThyTSQ
Disease-specific patient-reported outcome measures (PROMs) have been developed as important research tools in the study of various diseases. For hypothyroidism there exist three validated disease-specific ques...
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Article
Physical and organizational provision for installation, regulatory requirements and implementation of a simultaneous hybrid PET/MR-imaging system in an integrated research and clinical setting
The implementation of hybrid imaging systems requires thorough and anticipatory planning at local and regional levels. For installation of combined positron emission and magnetic resonance imaging systems (PET...
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Chapter and Conference Paper
Virtual Cerebellar Lesions Influence Verbal Working Memory a tDCS Study
Several studies suggest that the cerebellum is involved in cognitive functions. Findings in cerebellar patient studies are inconsistent due to small group sizes and different location of lesions. Here we used ...
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Article
A software tool for interactive exploration of intrinsic functional connectivity opens new perspectives for brain surgery
Functional connectivity analysis of resting-state functional magnetic resonance imaging data (fcrs-fMRI) has been shown to be a robust non-invasive method for localization of functional networks (without using...
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Open Access This content is freely available online to anyone, anywhere at any time.
Article
Enhancing the effect of repetitive I-wave paired-pulse TMS (iTMS) by adjusting for the individual I-wave periodicity
Repeated application of paired-pulse TMS over the primary motor cortex (M1) in human subjects with an inter-pulse interval (IPI) of 1.5 ms (iTMS1.5 ms) has been shown to significantly increase paired-pulse MEP (p...
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Article
Inverse mismatch and lesion growth in small subcortical ischaemic stroke
Infarction typically develops within the borders of an initial hypoperfused tissue. We prospectively investigated whether in small subcortical stroke patients infarct growth can occur beyond the margins of the...
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Article
Resting developments: a review of fMRI post-processing methodologies for spontaneous brain activity
Analytic tools for addressing spontaneous brain activity, as acquired with fMRI during the “resting-state,” have grown dramatically over the past decade. Along with each new technique, novel hypotheses about t...
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Chapter
Visual System
Combining both EEG and fMRI is still a challenging task. A large number of studies on the feasibility of EEG–fMRI for the visual system have been performed because it is an accessible and well-described system...
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Chapter
Principles of Multimodal Functional Imaging and Data Integration
In a system as complex as the human brain, one cannot conceive of meaningful events involving a change in a single observable (physiological parameter). Therefore, achieving the ultimate aim of a complete unde...
