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Foxl2 Regulates Ovarian Development Through Cyp19a1a-Mediated Estrogen Biosynthesis in the Silver Pomfret (Pampus argenteus)
The silver pomfret (Pampus argenteus) is a marine species with considerable economic value. The processes involved in gonadal maturation in P....
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Dynamic Equivalent Drainage Method for Urban Flood Modeling: A Rainfall-adaptive Fusion Approach
The scarcity of detailed drainage network data severely constrains urban flood modeling and risk assessment. To address this challenge, this study...
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A theory-driven exercise intervention to improve physical performance in community-dwelling older adults: a cluster randomized controlled trial delivered by general practitioners
BackgroundAge-related physical decline demands effective community-based interventions. Theory-driven programs, especially those led by general...
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Design and evaluation of a bifunctional fusion polypeptide for targeted delivery of tigecycline against drug-resistant Klebsiella pneumoniae
The overuse of antibiotics and the continuous evolution of drug-resistant bacteria present substantial obstacles to the clinical treatment of...
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Comparative transcriptome analysis reveals the responses of sweetpotato to continuous cropping stress
BackgroundContinuous cropping obstacles (CCO) severely limit the sustainable development of sweetpotato (Ipomoea batatas(L.) Lam.) industry....
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Clinical response and risk factors of fecal microbiota transplantation in children: a systematic review and meta-analysis
The objective of this study is to investigate the clinical response and incidence of adverse events (AEs) following fecal microbiota transplantation...
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Retrospective attention suppresses reward-associated interference in visual working memory
Retrospective cues are thought to prioritize goal-relevant representations in visual working memory, yet whether they actively suppress interference...
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The evaluation of application effects of multi-algorithm collaborative architecture in distributed hydrological models
In response to the increasing complexity of hydrological modeling demands driven by climate change and human activities, this study introduces a...
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SdLDL‑C/LDL‑C discordance as a practical surrogate for triglyceride‑associated cardiovascular risk: identification of at‑risk lipid phenotypes in the CHARLS prospective cohort
BackgroundDiscordance between small dense low-density lipoprotein cholesterol (sdLDL-C) and low-density lipoprotein cholesterol (LDL-C) levels is...
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Effects of Sowing Date on Yield and Quality Formation of Indica Rice in the Jianghuai Region
The yield and quality of rice are easily affected by climatic conditions. Selecting a suitable sowing date, in accordance with local climatic...
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Methods and applications of patient-derived organoid models for immune microenvironment and immunotherapy research in multiple cancer types
Lack of pre-clinical models that simulate the complex TME and translate to human immunity is list as the top one challenge in the area of cancer...
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What stole Chinese older adults’ life satisfaction? Integrating medical statistics and machine learning with a life-course perspective using CHARLS data
BackgroundAs China enters a rapidly aging era, understanding the determinants of life satisfaction among older adults has become a pressing research...
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Spatiotemporal drought variability in Gansu Province based on reconstructed land surface temperature
To address the increasing drought risks exacerbated by climate change in arid-semiarid regions, this study proposes a novel framework integrating...
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Generation of quartet reference materials for preimplantation genetic testing for structural rearrangements
BackgroundPreimplantation genetic testing for structural rearrangements (PGT-SR) facilitates the selection of embryos with balanced karyotype prior...
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USP30 senses serine/glycine levels to regulate serine biosynthesis and colorectal tumorigenesis by deubiquitinating FTO
Our previous studies demonstrated that the fat mass and obesity-associated protein (FTO) is upregulated in colorectal cancer (CRC). It demethylates...
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Exploring new applications of toasted chestnut shells as an oak alternative in distilled spirit aging
This study investigated the potential of toasted chestnut shells as a novel and cost-effective material for aging distilled spirits. Results showed...
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Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study
Chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease (ILD) and...
