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    Chapter

    Prostacyclin and its Analogues for the Therapy of Thromboembolic Disorders

    The discovery that blood vessels synthesize and release an unstable arachidonic acid metabolite, prostacyclin, which is a potent vasodilator and inhibitor of platelet aggregation (Moncada, Gryglewski, Bunting ...

    B. J. R. Whittle, S. Moncada in Thrombosis and Cardiovascular Disease (1984)

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    Chapter

    Biological significance and therapeutic potential of prostacyclin

    Prostacyclin and thromboxane A2 (TXA2) are both derived from arachidonic acid, a fatty acid present in the phospholipids of cell membranes. TXA2 is an unstable (t1/2 30s at 37 °C), powerful vasoconstrictor agent ...

    S. Moncada, J. R. Vane in Organ Preservation (1982)

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    Chapter

    Prostacyclin

    In 1976, the Wellcome group discovered that prostaglandin endoperoxides were transformed by a microsomal enzyme from blood vessels into an unstable substance which is a potent vasodilator and an inhibitor of p...

    S. Moncada, J. R. Vane in The Prostaglandin System (1981)

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    Chapter

    Identification of Prostacyclin, Thromboxane A2 and Prostaglandins in Pharmacological Experiments

    Many authors have determined prostaglandins (PGs) in a novel situation using only one technique, for example bioassay, radioimmunoassay or thin layer chromatography. Data from these experiments may suggest tha...

    J. A. Salmon, P. Salzman, S. Moncada in Prostaglandins, Prostacyclin, and Thrombox… (1980)

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    Chapter

    The Pharmacology and Clinical Potential of Prostacyclin

    Smith & Willis (1970) showed that aggregating platelets release, among other products, prostaglandins of the E and F type. Shortly afterwards it was shown that aspirin-like drugs inhibit prostaglandin biosynth...

    S. Moncada, J. R. Vane in Clinical Pharmacology & Therapeutics (1980)

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    Chapter

    Pain and Inflammatory Mediators

    Pain and hyperalgesia are common features of the inflammatory process. Some pain arises as an immediate sensation after tissue injury, due to direct stimulation of sensory nerve endings. Another component aris...

    S. Moncada, S. H. Ferreira, J. R. Vane in Inflammation (1978)

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    Article

    Prostaglandin endoperoxides and thromboxanes: Formation and effects

    The formation of prostaglandin (PG) endoperoxides and thromboxane A2 (TXA2) as components of rabbit aorta contracting substance is described. Their activity and their possible implication in pathophysiological pr...

    S. Moncada in Naunyn-Schmiedeberg's Archives of Pharmacology (1977)

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    Article

    The blockade of the local generation of prostaglandins explains the analgesic action of aspirin

    S. H. Ferreira, S. Moncada, J. R. Vane in Agents and Actions (1973)

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