Abstract
Recently, remarkable progress has been witnessed in the nanoparticles-based delivery of anticancer agents to improve therapeutic outcomes. Various nanoparticles such as dendrimers, liposomes, solid lipid nanoparticles, quantum dots, carbon nanotubes, fullerenes, and polysaccharidal polymeric nanoparticles have been employed. Out of numerous polysaccharide options available to load chemotherapeutic agents, a polysaccharide named fucoidan is a promising option. Fucoidan is isolated from various marine algae species and is built of L-fucose monomeric units. This natural polysaccharide possesses numerous pharmacological outcomes like antithrombotic, antiviral, antimicrobial, anti-inflammatory, and anticancer activities. Fucoidan can be transformed into nanoparticles in combination with other polymers using polyelectrolyte complexation, emulsification, and ionic gelation. Fucoidan has good biocompatibility, biodegradability, and stability. It can be chemically and biochemically modified to enhance its adherence to the tumor tissue, improving the bioavailability of anticancer agents. This chapter focuses on the various preparation methods of fucoidan-based nanoparticles and their use as a carrier for the targeted delivery of anticancer agents. Furthermore, the chapter also discusses the mechanism of action of fucoidan toward cancer cells without having chemotherapeutic side effects. The chapter also gives insight into the nanotechnological applications and limitations of fucoidan-based nanoparticles in delivering anticancer agents.
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Chaurawal, N., Raza, K. (2024). Fucoidan-Based Nanoparticles for the Targeted Delivery of Anticancer Agents. In: Sobti, R.C., Ganguly, N.K., Kumar, R. (eds) Handbook of Oncobiology: From Basic to Clinical Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-99-6263-1_71
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