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Fungal Endophyte-Mediated Green Synthesis of Silver Nanoparticles as Potential Anticancer Agent: Current Perspective and Challenges

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Handbook of Oncobiology: From Basic to Clinical Sciences

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Abstract

Endophytic microorganisms establish symbiotic relationship with their host plants and also have a unique ability to mimic bioactive metabolite produced from host plants. Bioactive compounds produced from fungal endophyte have tendency to reduce metallic ions such as silver, gold, platinum, and zinc into nanoparticles. Biosynthesis of fungal endophyte-mediated silver nanoparticles (AgNPs) has evolved as a frontier of nanotechnology. For decades, silver has been observed as a nontoxic and harmless inorganic agent which is utilized as antibacterial or antifungal agent. Silver exhibits an exceptional physical, chemical, and a wide range of potential biological activities, predominantly in the form of nanoparticles. Although the effective biosynthesis of fungal endophyte-mediated AgNPs and their antiapoptotic and antiproliferative property have been accounted as of now, the exact mechanism of synthesis of nanoparticles remains unclear. The current chapter gives a brief outline of the possible mechanism of fungal endophyte-mediated synthesis of AgNPs and its anticancer properties. Moreover, it also provides an insight for the mycogenic synthesis and characterization of AgNPs mediated by fungal endophyte using various high-throughput techniques including UV-Visible spectrophotometer, Fourier transform infrared spectroscopy (FT-IR), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM) equipped with energy dispersive X-ray analysis (EDAX), and X-ray Powder Diffraction (XRD). Additionally, it also describes bottlenecks in the field of myconanotechnology including manufacturing at large scale, improved stability, and reduced time to acquire compatible size and shape of AgNPs and their potential uses in cancer research.

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Acknowledgments

NR would like to thank University Grants Commission, New Delhi, India, for Junior and Senior Research Fellowship. PG would like to thank the Science and Engineering Research Board (SERB), New Delhi, India, for Junior Research Fellowship under Empowerment and Equity Opportunities for Excellence in Science (EMEQ) scheme (EEQ/2019/000025) and non-NET research fellowship from Banaras Hindu University, Varanasi, India, under University Grants Commission. AV would like to thank Council of Scientific and Industrial Research, New Delhi, India, for Junior Research Fellowship. SS would like to thank University Grants Commission, New Delhi, India, for Junior Research Fellowship. Research in the VG laboratory is supported by the SERB-EMEQ project (EEQ/2019/000025), BSR-UGC Start-Up grant from University Grants Commission, New Delhi, India, and internal funding (Seed Grant) from Banaras Hindu University, Varanasi, India, under the Institution of Eminence Scheme.

Conflict of interest

The corresponding author on behalf of all the authors declares no potential conflict of interest.

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  1. Nilesh Rai, Priyamvada Gupta, and Ashish Verma contributed equally to this work

Authors and Affiliations

  1. Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Nilesh Rai, Priyamvada Gupta, Ashish Verma, Swati Singh, Harshita Tiwari, Rajiv Kumar, Santosh Kumar Singh & Vibhav Gautam

  2. Department of Botany, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Harshita Tiwari

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  1. Nilesh Rai
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Correspondence to Vibhav Gautam .

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  1. Dept. Biotechnology, Panjab University, Chandigarh, Chandigarh, India

    R. C. Sobti

  2. NCR Biotech Science Cluster, Translational Health Sci & Tech Inst, Faridabad, Haryana, India

    Nirmal K. Ganguly

  3. Cancer Research Institute, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India

    Rakesh Kumar

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  1. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

    Indu Pal Kaur

  2. Department of Biotechnology, Panjab University, Chandigarh, India

    Ranbir Chander Sobti

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Rai, N. et al. (2024). Fungal Endophyte-Mediated Green Synthesis of Silver Nanoparticles as Potential Anticancer Agent: Current Perspective and Challenges. In: Sobti, R.C., Ganguly, N.K., Kumar, R. (eds) Handbook of Oncobiology: From Basic to Clinical Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-99-6263-1_70

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