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Depression and LUT (Psychogenic LUTS)

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Handbook of Neurourology

Abstract

This chapter reviewed current concepts of LUT dysfunction due to depression/anxiety, also called “bladder somatic symptom disorder (SSD).” It should always be careful to distinguish bladder SSD (due to psychiatric cause) and “true” neurologic/organic bladder dysfunction. In order to do so, (1) situation dependence (close association with life event in some), (2) urodynamic increased bladder sensation/hypersensitivity, and (3) no neurologic/organic diseases, in addition to (4) other stress symptoms (insomnia, etc.), are the clues to suspect/diagnose “bladder SSD.” Urodynamics in those patients showed, to a lesser extent, underactive bladder without post-void residual. These findings might well reflect biological changes of the depressive brain, e.g., decrease in serotonin, GABA, and possibly increase in CRH, etc. Treatment of “bladder SSD” can follow that of general depression/anxiety and also add bladder drugs.

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Sakakibara, R., Katsuragawa, S. (2023). Depression and LUT (Psychogenic LUTS). In: Liao, L., Madersbacher, H. (eds) Handbook of Neurourology. Springer, Singapore. https://doi.org/10.1007/978-981-99-1659-7_78

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