Skip to main content

Disc Disease

  • Reference work entry
  • First Online:
Handbook of Neurourology

Abstract

Urinary complaints and voiding abnormalities are well-known sequelae of intervertebral disc disease and can have a substantial impact on patients’ overall quality of life. Common bladder changes include detrusor overactivity, incontinence, and detrusor areflexia, with the long-term possibility of decreased bladder capacity and compliance which may lead to deleterious effects on renal function. Prompt evaluation and management of the underlying spinal condition are important for long-term bladder outcomes; however, bladder dysfunction may still persist even after surgical decompression. Therefore, it is important for urologists to be familiar with these disease processes and outcomes, in addition to the appropriate urologic evaluation, management options, and follow-up in order to offer the best comprehensive care for these complex patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 999.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. National Institute of Neurological Disorders and Stroke 2015

    Google Scholar 

  2. D.F. Fardon, A.L. Williams, E.J. Dohring, F.R. Murtagh, S.L.G. Rothman, G.K. Sze, Lumbar disc nomenclature: Version 2.0: Recommendations of the combined task forces of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology. Spine J. 14(11), 2525–2545 (2014)

    Article  PubMed  Google Scholar 

  3. W. Lauerman, S. Scherpink, S. Wiesel, The Spine. Essentials of Orthopedic Surgery, 1st. edn. (Springer, New York, 2011), pp. 103–118

    Google Scholar 

  4. G. Siracusa, A. Sparacino, V. Lentini, Neurogenic bladder and disc disease: A brief review. Curr. Med. Res. Opin. 29(8), 1025–1031 (2013)

    Article  CAS  PubMed  Google Scholar 

  5. H. Goldman, R. Appell, Voiding dysfunction in women with lumbar disc prolapse. Int. Urogynecol. J. 10(2), 134–138 (1999)

    Article  CAS  Google Scholar 

  6. F. Tamburrelli, M. Genitiempo, M. Bochicchio, L. Donisi, C. Ratto, Cauda equina syndrome: Evaluation of the clinical outcome. Eur. Rev. Med. Pharmacol. Sci. 18(7), 1098–1105 (2014)

    CAS  PubMed  Google Scholar 

  7. S. Fraser, L. Roberts, E. Murphy, Cauda equina syndrome: A literature review of its definition and clinical presentation. Arch. Phys. Med. Rehabil. 90(11), 1964–1968 (2009)

    Article  PubMed  Google Scholar 

  8. U.M. Ahn, N.U. Ahn, J.M. Buchowski, E.S. Garrett, A.N. Sieber, J.P. Kostuik, Cauda equina syndrome secondary to lumbar disc herniation: A meta-analysis of surgical outcomes. Spine 25(12), 1515–1522 (2000)

    Article  CAS  PubMed  Google Scholar 

  9. H. Bečulić, R. Skomorac, A. Jusić, F. Alić, M. Imamović, A. Mekić-Abazović, et al., Impact of timing on surgical outcome in patients with cauda equina syndrome caused by lumbar disc herniation. Med. Glas. (Zenica) 13(2), 136–141 (2016)

    PubMed  Google Scholar 

  10. N. Srikandarajah, M.A. Boissaud-Cooke, S. Clark, M.J. Wilby, Does early surgical decompression in cauda equina syndrome improve bladder outcome? Spine 40(8), 580–583 (2015)

    Article  PubMed  Google Scholar 

  11. A. Ahad, M. Elsayed, H. Tohid, The accuracy of clinical symptoms in detecting cauda equina syndrome in patients undergoing acute MRI of the spine. Neuroradiol. J. 28(4), 438–442 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  12. P. Sylvester, J. McLoughlin, G. Sibley, P. Dorman, J. Kabala, I. Ormerod, Neuropathic urinary retention in the absence of neurological signs. Postgrad. Med. J. 71(842), 747–748 (1995)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. T. Yamanishi, K. Yasuda, T. Yuki, R. Sakakibara, T. Uchiyama, T. Kamai, et al., Urodynamic evaluation of surgical outcome in patients with urinary retention due to central lumbar disc prolapse. Neurourol. Urodyn. 22(7), 670–675 (2003)

    Article  PubMed  Google Scholar 

  14. D.A. Ginsberg, T.B. Boone, A.P. Cameron, A. Gousse, M.R. Kaufman, E. Keays, et al., The AUA/SUFU guideline on adult neurogenic lower urinary tract dysfunction: Diagnosis and evaluation. J. Urol. 206(5), 1097–1105 (2021)

    Article  PubMed  Google Scholar 

  15. J. Pannek, J. Blok, D. Castro-Diaz, G. Del Popolo, G. Kramer, P. Radziszewski, et al., Neurogenic lower urinary tract dysfunction, in European Association of Urology (EAU) Guidelines, (Elsevier, Cham, 2013)

    Google Scholar 

  16. Z. Bartolin, I. Savic, Z. Persec, Relationship between clinical data and urodynamic findings in patients with lumbar intervertebral disk protrusion. Urol. Res. 30(4), 219–222 (2002)

    Article  CAS  PubMed  Google Scholar 

  17. D. Dong, Z. Xu, B. Shi, J. Chen, X. Jiang, H. Wang, Clinical significance of urodynamic studies in neurogenic bladder dysfunction caused by intervertebral disk hernia. Neurourol. Urodyn. 25(5), 446–450 (2006)

    Article  PubMed  Google Scholar 

  18. G.R. Buttermann, Treatment of lumbar disc herniation: Epidural steroid injection compared with discectomy: A prospective, randomized study. JBJS 86(4), 670–679 (2004)

    Article  Google Scholar 

  19. V. Kumar, V. Baburaj, R.K. Rajnish, S.S. Dhatt, Outcomes of cauda equina syndrome due to lumbar disc herniation after surgical management and the factors affecting it: A systematic review and meta-analysis of 22 studies with 852 cases. Eur. Spine J. 31, 1–11 (2021)

    Google Scholar 

  20. T.P. Barker, N. Steele, G. Swamy, A. Cook, A. Rai, R. Crawford, et al., Long-term core outcomes in cauda equina syndrome. Bone Joint J. 103(9), 1464–1471 (2021)

    Article  PubMed  Google Scholar 

  21. M.E. Brooks, M. Moreno, A. Sidi, Z.F. Braf, Urologic complications after surgery on lumbosacral spine. Urology 26(2), 202–204 (1985)

    Article  CAS  PubMed  Google Scholar 

  22. M.J. Drake, A. Apostolidis, A. Cocci, A. Emmanuel, J.B. Gajewski, S.C. Harrison, et al., Neurogenic lower urinary tract dysfunction: Clinical management recommendations of the neurologic incontinence Committee of the Fifth International Consultation on incontinence 2013. Neurourol. Urodyn. 35(6), 657–665 (2016)

    Article  PubMed  Google Scholar 

  23. N. Vásquez, S. Knight, J. Susser, A. Gall, P. Ellaway, M. Craggs, Pelvic floor muscle training in spinal cord injury and its impact on neurogenic detrusor over-activity and incontinence. Spinal Cord 53(12), 887–889 (2015)

    Article  PubMed  Google Scholar 

  24. D. McClurg, R. Ashe, K. Marshall, A. Lowe-Strong, Comparison of pelvic floor muscle training, electromyography biofeedback, and neuromuscular electrical stimulation for bladder dysfunction in people with multiple sclerosis: A randomized pilot study. Neurourol. Urodyn. 25(4), 337–348 (2006)

    Article  CAS  PubMed  Google Scholar 

  25. R.S. Lavelle, B. Coskun, C.D. Bacsu, L.A. Gliga, A.L. Christie, G.E. Lemack, Quality of life after suprapubic catheter placement in patients with neurogenic bladder conditions. Neurourol. Urodyn. 35(7), 831–835 (2016)

    Article  PubMed  Google Scholar 

  26. M.J. Kennelly, W.B. DeVoe, Overactive bladder: Pharmacologic treatments in the neurogenic population. Rev. Urol. 10(3), 182 (2008)

    PubMed  PubMed Central  Google Scholar 

  27. V. Khullar, G. Amarenco, J.C. Angulo, J. Cambronero, K. Høye, I. Milsom, et al., Efficacy and tolerability of mirabegron, a β3-adrenoceptor agonist, in patients with overactive bladder: results from a randomised European–Australian phase 3 trial. Eur. Urol. 63(2), 283–295 (2013)

    Article  CAS  PubMed  Google Scholar 

  28. S. Herschorn, J. Barkin, D. Castro-Diaz, J.M. Frankel, M. Espuna-Pons, A.E. Gousse, et al., A phase III, randomized, double-blind, parallel-group, placebo-controlled, multicentre study to assess the efficacy and safety of the β3 adrenoceptor agonist, mirabegron, in patients with symptoms of overactive bladder. Urology 82(2), 313–320 (2013)

    Article  PubMed  Google Scholar 

  29. J. Wöllner, J. Pannek, Initial experience with the treatment of neurogenic detrusor overactivity with a new β-3 agonist (mirabegron) in patients with spinal cord injury. Spinal Cord 54(1), 78–82 (2016)

    Article  PubMed  Google Scholar 

  30. T. Cheng, W.-b. Shuang, D.-d. Jia, M. Zhang, X.-n. Tong, W.-d. Yang, et al., Efficacy and safety of onabotulinumtoxinA in patients with neurogenic detrusor overactivity: A systematic review and meta-analysis of randomized controlled trials. PLoS One 11(7), e0159307 (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  31. T.M. Kessler, D. La Framboise, S. Trelle, C.J. Fowler, G. Kiss, J. Pannek, et al., Sacral neuromodulation for neurogenic lower urinary tract dysfunction: Systematic review and meta-analysis. Eur. Urol. 58(6), 865–874 (2010)

    Article  PubMed  Google Scholar 

  32. D.S. Engeler, D. Meyer, D. Abt, S. Müller, H.-P. Schmid, Sacral neuromodulation for the treatment of neurogenic lower urinary tract dysfunction caused by multiple sclerosis: A single-Centre prospective series. BMC Urol. 15(1), 1–6 (2015)

    Article  Google Scholar 

  33. P. Zhang, J.Y. Wang, Y. Zhang, L. Liao, L. Jw, Q. Ling, et al., Results of sacral neuromodulation therapy for urinary voiding dysfunction: Five-year experience of a retrospective, multicenter study in China. Neuromodulation: Technology at the Neural. Interface 22(6), 730–737 (2019)

    Google Scholar 

  34. F.M. Martens, P.P. Den Hollander, G.J. Snoek, E.L. Koldewijn, P.E. Van Kerrebroeck, J.P. Heesakkers, Quality of life in complete spinal cord injury patients with a Brindley bladder stimulator compared to a matched control group. Neurourol. Urodyn. 30(4), 551–555 (2011)

    Article  PubMed  Google Scholar 

  35. E. Opisso, A. Borau, A. Rodriguez, J. Hansen, N. Rijkhoff, Patient controlled versus automatic stimulation of pudendal nerve afferents to treat neurogenic detrusor overactivity. J. Urol. 180(4), 1403–1408 (2008)

    Article  CAS  PubMed  Google Scholar 

  36. F.F. Farag, F.M. Martens, N.J. Rijkhoff, J.P. Heesakkers, Dorsal genital nerve stimulation in patients with detrusor overactivity: A systematic review. Curr. Urol. Rep. 13(5), 385–388 (2012)

    Article  PubMed  Google Scholar 

  37. T.M. Fandel, A. Trivedi, C.R. Nicholas, H. Zhang, J. Chen, A.F. Martinez, et al., Transplanted human stem cell-derived interneuron precursors mitigate mouse bladder dysfunction and central neuropathic pain after spinal cord injury. Cell Stem Cell 19(4), 544–557 (2016)

    Article  CAS  PubMed  Google Scholar 

  38. H.Y. Yu, J.H. Shin, H. Yun, C.-M. Ryu, S. Lee, J. Heo, et al., A preclinical study of human embryonic stem cell-derived mesenchymal stem cells for treating detrusor underactivity by chronic bladder ischemia. Stem Cell Rev. Rep. 17(6), 2139–2152 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Roger R. Dmochowski .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer Nature Singapore Pte Ltd.

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Sebesta, E.M., Gleicher, S., Kowalik, C.G., Cohn, J.A., Dmochowski, R.R. (2023). Disc Disease. In: Liao, L., Madersbacher, H. (eds) Handbook of Neurourology. Springer, Singapore. https://doi.org/10.1007/978-981-99-1659-7_66

Download citation

  • DOI: https://doi.org/10.1007/978-981-99-1659-7_66

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-1658-0

  • Online ISBN: 978-981-99-1659-7

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics