Skip to main content
SpringerLink
Log in

Parkinson’s Disease

  • Reference work entry
  • First Online:
Handbook of Neurourology

  • 425 Accesses

Abstract

This chapter reviewed the current concepts of bladder dysfunction in Parkinson’s disease (PD). Central nervous system pathology is clearly associated with bladder dysfunction (urinary urgency/frequency) in PD. Anticholinergic agents and possibly beta-3 adrenergic receptor agonist are the choice to treat bladder dysfunction that do not easily penetrate the blood-brain barrier (BBB). These treatments are beneficial in maximizing patients’ quality of life. The International Continence Society (ICS) guideline is a good reference for urologists to manage such patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 999.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. D.S. Goldstein, L. Sewell, Y. Sharabi, Autonomic dysfunction in PD: A window to early detection? J. Neurol. Sci. (2011 Apr 27). [Epub ahead of print]

    Google Scholar 

  2. R. Sakakibara, T. Uchiyama, T. Yamanishi, K. Shirai, T. Hattori, Bladder and bowel dysfunction in Parkinson’s disease. J. Neural Transm. 115, 443–460 (2008)

    Google Scholar 

  3. S. Jain, Multi-organ autonomic dysfunction in Parkinson disease. Parkinsonism Relat. Disord. 17, 77–83 (2011)

    Article  PubMed  Google Scholar 

  4. C.W. McGrother, C. Jagger, M. Clarke, C.M. Castleden, Handicaps associated with incontinence: Implications for management. J. Epidemiol.Commun. Health 44, 246–248 (1990)

    Article  CAS  Google Scholar 

  5. R. Sakakibara, H. Shinotoh, T. Uchiyama, M. Sakuma, M. Kashiwado, M. Yoshiyama, T. Hattori, Questionnaire-based assessment of pelvic organ dysfunction in Parkinson’s disease. Auton. Neurosci. 92, 76–85 (2001)

    Article  CAS  PubMed  Google Scholar 

  6. T. Uchiyama, R. Sakakibara, T. Hattori, T. Yamanishi, Short-term effect of a single levodopa dose on micturition disturbance in Parkinson’s disease patients with the wearing-off phenomenon. Mov. Disord. 18, 573–578 (2003)

    Article  PubMed  Google Scholar 

  7. W.C. de Groat, Integrative control of the lower urinary tract: Preclinical perspective. BJP 147, S25–S40 (2006)

    PubMed  PubMed Central  Google Scholar 

  8. Sakakibara R, Fowler CJ. Brain disease (Chapter 9), in Seminars in Clinical Neurology (by World Federation of Neurology). Neurologic bladder, bowel, and sexual function, ed. by C.J. Fowler (Elsevier, Boston, 2001), pp. 229–243

    Google Scholar 

  9. R. Sakakibara, M. Mori, T. Fukutake, K. Kita, Orthostatic hypotension in a case with multiple sclerosis. Clin. Auton. Res. 7, 163–165 (1997)

    Article  CAS  PubMed  Google Scholar 

  10. P. Abrams, L. Cardozo, M. Fall, D. Griffiths, P. Rosier, U. Ulmsten, P. van Kerrebroeck, A. Victor, A. Wein, Standardisation Sub-committee of the International Continence Society, The standardization of terminology of lower urinary tract function: Report from the standardization sub-committee of the International Continence Society. Neurourol. Urodyn. 21, 167–178 (2002)

    Article  PubMed  Google Scholar 

  11. B.F. Blok, G. Holstege, The central control of micturition and continence: Implications for urology. Br. J. Urol. Int. 83(Suppl 2), 1–6 (1999)

    Google Scholar 

  12. R. Sakakibara, K. Nakazawa, K. Shiba, Y. Nakajima, T. Uchiyama, M. Yoshiyama, T. Yamanishi, T. Hattori, Firing patterns of micturition-related neurons in the pontine storage centre in cats. Auton. Neurosci. 99, 24–30 (2002)

    Article  PubMed  Google Scholar 

  13. R.B.C. Kavia, R. Dasgupta, C.J. Fowler, Functional imaging and the central control of the bladder. J. Comp. Neurol. 493, 27–32 (2005)

    Article  PubMed  Google Scholar 

  14. R. Sakakibara, T. Hattori, K. Yasuda, T. Yamanishi, M. Tojo, M. Mori, Micturitional disturbance in Wernicke’s encephalopathy. Neurourol. Urodyn. 16, 111–115 (1997)

    Article  CAS  PubMed  Google Scholar 

  15. S. Matsuura, J.W. Downie, G.V. Allen, Volume-evoked micturition reflex is mediated by the ventrolateral periaqueductal gray in anesthetized rat. Am. J. Phys. 275, R2049–R2055 (1998)

    CAS  Google Scholar 

  16. Z. Liu, R. Sakakibara, K. Nakazawa, T. Uchiyama, T. Yamamoto, T. Ito, T. Hattori, Micturition-related neuronal firing in the periaqueductal gray area in cats. Neuroscience 126, 1075–1082 (2004)

    Article  CAS  PubMed  Google Scholar 

  17. H. Yaguchi, H. Soma, Y. Miyazaki, J. Tashiro, I. Yabe, S. Kikuchi, H. Sasaki, H. Kakizaki, F. Moriwaka, K. Tashiro, A case of acute urinary retention caused by periaqueductal grey lesion. J. Neurol. Neurosurg. Psychiatry 75, 1202–1203 (2004)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. C.D. Betts, R. Kapoor, C.J. Fowler, Pontine pathology and voiding dysfunction. Br. J. Urol. 70, 100–102 (1992)

    Article  CAS  PubMed  Google Scholar 

  19. R. Sakakibara, T. Hattori, K. Yasuda, T. Yamanishi, Micturitional disturbance and pontine tegmental lesion; urodynamic and MRI analyses of the vascular cases. J. Neurol. Sci. 141, 105–110 (1996)

    Article  CAS  PubMed  Google Scholar 

  20. M. Sasaki, Role of Barrington’s nucleus in micturition. J. Comp. Neurol. 493, 21–26 (2005)

    Article  PubMed  Google Scholar 

  21. G. Matsumoto, T. Hisamitsu, W.C. De Groat, Role of glutamate and NMDA receptors in the descending limb of the spinobulbospinal micturition reflex pathway of the rat. Neurosci. Lett. 183, 58–61 (1995)

    Article  CAS  PubMed  Google Scholar 

  22. B.F. Blok, H. de Weerd, G. Holstege, The pontine micturition center projects to sacral cord GABA immunoreactive neurons in the cat. Neurosci. Lett. 233, 109–112 (1997)

    Article  CAS  PubMed  Google Scholar 

  23. C.J. Fowler, Integrated control of lower urinary tract: Clinical perspective. BJP 147, S14–S24 (2006)

    CAS  PubMed  PubMed Central  Google Scholar 

  24. W.D. Steers, Pathophysiology of overactive and urge urinary incontinence. Rev. Urol. 4(Suppl 4), S7–S18 (2002)

    PubMed  PubMed Central  Google Scholar 

  25. K.E. Andersson, Mechanisms of disease: Central nervous system involvement in overactive bladder syndrome. Nat. Clin. Pract. Urol. 1, 103–108 (2004)

    Article  PubMed  Google Scholar 

  26. O. Yokoyama, S. Yotsuyanagi, H. Akino, H. Moriyama, Y. Matsuta, M. Namiki, RNA synthesis in pons necessary for maintenance of bladder overactivity after cerebral infarction in rat. J. Urol. 169, 1878–1884 (2003)

    Article  CAS  PubMed  Google Scholar 

  27. O. Yokoyama, M. Yoshiyama, M. Namiki, W.C. de Groat, Changes in dopaminergic and glutamatergic excitatory mechanisms of micturition reflex after middle cerebral artery occlusion in conscious rats. Exp. Neurol. 173, 129–135 (2002)

    Article  CAS  PubMed  Google Scholar 

  28. S. Seki, Y. Igawa, K. Kaidoh, O. Ishizuka, O. Nishizawa, K.E. Andersson, Role of dopamine D1 and D2 receptors in the micturition reflex in conscious rats. Neurourol. Urodyn. 20, 105–113 (2001)

    Article  CAS  PubMed  Google Scholar 

  29. N. Yoshimura, S. Kuno, M.B. Chancellor, W.C. de Groat, S. Seki, Dopaminergic mechanisms underlying bladder hyperactivity in rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. Br. J. Pharmacol. 139, 1425–1432 (2003)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. N. Yoshimura, E. Mizuta, O. Yoshida, S. Kuno, Therapeutic effects of dopamine D1/D2 receptor agonists on detrusor hyperreflexia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinsonian cynomolgus monkeys. J. Pharmacol. Exp. Ther. 286, 228–233 (1998)

    CAS  PubMed  Google Scholar 

  31. S. Nour, C. Svarer, J.K. Kristensen, O.B. Paulson, I. Law, Cerebral activation during micturition in normal men. Brain 123, 781–789 (2000)

    Article  PubMed  Google Scholar 

  32. T. Kitta, H. Kakizaki, T. Furuno, K. Moriya, H. Tanaka, T. Shiga, N. Tamaki, N. Yabe, H. Sasaki, K. Nonomura, Brain activation during detrusor overactivity in patients with parkinson’s disease: A PET study. J. Urol. 175, 994–998 (2006)

    Article  PubMed  Google Scholar 

  33. R. Sakakibara, H. Shinotoh, T. Uchiyama, M. Yoshiyama, T. Hattori, T. Yamanishi, SPECT imaging of the dopamine transporter with [123I]-beta-CIT reveals marked decline of nigrostriatal dopaminergic function in Parkinson’s disease with urinary dysfunction. J. Neurol. Sci. 187, 55–59 (2001)

    Article  CAS  PubMed  Google Scholar 

  34. K. Winge, L. Friberg, L. Werdelin, K.K. Nielsen, H. Stimpel, Relationship between nigrostriatal dopaminergic degeneration, urinary symptoms, and bladder control in Parkinson’s disease. Eur. J. Neurol. 12, 842–850 (2005)

    Article  CAS  PubMed  Google Scholar 

  35. F. Tateno, R. Sakakibara, T. Ogata, Y. Aiba, O. Takahashi, M. Sugiyama, The relationship between lower urinary tract function and (123) ioflupane scintigraphy in drug-naïve Parkinson’s disease. Auton. Neurosci. 233, 102813 (2021). https://doi.org/10.1016/j.autneu.2021.102813. Online ahead of print

    Article  CAS  PubMed  Google Scholar 

  36. R. Sakakibara, K. Nakazawa, T. Uchiyama, M. Yoshiyama, T. Yamanishi, T. Hattori, Micturition-related electrophysiological properties in the substantia nigra pars compacta and the ventral tegmental area in cats. Auton. Neurosci. 102, 30–38 (2002)

    Article  PubMed  Google Scholar 

  37. T. Yamamoto, R. Sakakibara, K. Hashimoto, K. Nakazawa, T. Uchiyama, Z. Liu, T. Ito, T. Hattori, Striatal dopamine level increases in the urinary storage phase in cats: An in vivo microdialysis study. Neuroscience 135, 299–303 (2005)

    Article  CAS  PubMed  Google Scholar 

  38. Y. Smith, M.D. Bevan, E. Shink, J.P. Bolam, Microcircuitry of the direct and indirect pathways of the basal ganglia. Neuroscience 86, 353–387 (1998)

    CAS  PubMed  Google Scholar 

  39. R. Sakakibara, K. Nakazawa, T. Uchiyama, M. Yoshiyama, T. Yamanishi, T. Hattori, Effects of subthalamic nucleus stimulation on the micturation reflex in cats. Neuroscience 120, 871–875 (2003)

    Article  CAS  PubMed  Google Scholar 

  40. A.L. Dalmose, C.R. Bjarkam, J.C. Sorensen, J.C. Djurhuus, T.M. Jorgensen, Effects of high frequency deep brain stimulation on urine storage and voiding function in conscious minipigs. Neurourol. Urodyn. 23, 265–272 (2004)

    Article  CAS  PubMed  Google Scholar 

  41. T. Kitta, M. Matsumoto, H. Tanaka, T. Mitsui, M. Yoshioka, K. Nonomura, GABAergic mechanism mediated via D receptors in the rat periaqueductal gray participates in the micturition reflex: An in vivo microdialysis study. Eur. J. Neurosci. 27, 3216–3225 (2008)

    Article  PubMed  Google Scholar 

  42. K. Hashimoto, T. Oyama, Y. Ukay, K. Kimura, T. Sugiyama, Y.C. Park, T. Kurita, Selective destruction of dopamine neurones of the ventral tegmental area, but not the substantia nigra, impairs reflex micturition in rats. Neurourol. Urodyn. 16, 470–471 (1997)

    Google Scholar 

  43. K. Hashimoto, T. Oyama, T. Sugiyama, Y.C. Park, T. Kurita, Neuronal excitation in the ventral tegmental area modulates the micturition reflex mediated via the dopamine D(1) and D(2) receptors in rats. J. Pharmacol. Sci. 92, 143–148 (2003)

    Article  CAS  PubMed  Google Scholar 

  44. T. Yamamoto, R. Sakakibara, K. Nakazawa, T. Uchiyama, E. Shimizu, T. Hattori, S. Kuwabara, Neuronal activities of forebrain structures with respect to bladder contraction in cats. Neurosci. Lett. 473, 42–47 (2010)

    Article  CAS  PubMed  Google Scholar 

  45. J. Andrew, P.W. Nathan, Lesions of the anterior frontal lobes and disturbances of micturition and defaecation. Brain 87, 233–262 (1964)

    Article  CAS  PubMed  Google Scholar 

  46. J. Andrew, P.W. Nathan, The cerebral control of micturition. Proc. R. Soc. Med. 58, 553–555 (1965)

    CAS  PubMed  PubMed Central  Google Scholar 

  47. R. Dasgupta, R.B. Kavia, C.J. Fowler, Cerebral mechanisms and voiding function. BJU Int. 99, 731–734 (2007)

    Article  PubMed  Google Scholar 

  48. D. Griffiths, S.D. Tadic, Bladder control, urgency, and urge incontinence: Evidence from functional brain imaging. Neurourol. Urodyn. 27, 466–474 (2008)

    Article  PubMed  Google Scholar 

  49. T. Yamamoto, R. Sakakibara, K. Nakazawa, T. Uchiyama, E. Shimizu, T. Hattori, Effects of electrical stimulation of the striatum on bladder activity in cats. Neurourol. Urodyn. 28, 549–554 (2009)

    Article  PubMed  Google Scholar 

  50. J. Herzog, P.H. Weiss, A. Assmus, B. Wefer, C. Seif, P.M. Braun, H. Herzog, J. Volkmann, G. Deuschl, G.R. Fink, Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson’s disease. Brain 129, 3366–3375 (2006)

    Article  PubMed  Google Scholar 

  51. J. Herzog, P.H. Weiss, A. Assmus, B. Wefer, C. Seif, P.M. Braun, M.O. Pinsker, H. Herzog, J. Volkmann, G. Deuschl, G.R. Fink, Improved sensory gating of urinary bladder afferents in Parkinson’s disease following subthalamic stimulation. Brain 131, 132–145 (2008)

    Article  PubMed  Google Scholar 

  52. G.F. Murnaghan, Neurogenic disorders of the bladder in parkinsonism. Br. J. Urol. 33, 403–409 (1961)

    Article  CAS  PubMed  Google Scholar 

  53. T. Hattori, K. Yasuda, K. Kita, K. Hirayama, Voiding dysfunction in Parkinson’s disease. Jpn. J. Psychiatry Neurol. 46, 181–186 (1992)

    CAS  PubMed  Google Scholar 

  54. R. Gray, G. Stern, J. Malone-Lee, Lower urinary tract dysfunction in Parkinson’s disease: Changes relate to age and not disease. Age Ageing 24, 499–504 (1995)

    Article  CAS  PubMed  Google Scholar 

  55. T. Hald, B. We, The Urinary Bladder, Neurology and Dynamics (Williams and Wilkins, Baltimore, 1982)

    Google Scholar 

  56. J.T. Andersen, Disturbances of bladder and urethral function in Parkinson’s disease. Int. Urol. Nephrol. 17, 35–41 (1985)

    Article  CAS  PubMed  Google Scholar 

  57. Y. Berger, J.G. Blaivas, E.R. DeLaRocha, J.M. Salinas, Urodynamic findings in Parkinson’s disease. J. Urol. 138, 836–838 (1987)

    Article  CAS  PubMed  Google Scholar 

  58. R. Sakakibara, T. Hattori, T. Uchiyama, T. Yamanishi, Urinary function in the elderly with and without leukoaraiosis; in relation to cognitive and gait function. J. Neurol. Neurosurg. Psychiatry 67, 658–660 (1999)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. S. Gilman, P.A. Low, N. Quinn, A. Albanese, Y. Ben-Shlomo, C.J. Fowler, H. Kaufmann, T. Klockgether, A.E. Lang, P.L. Lantos, I. Litvan, C.J. Mathias, E. Oliver, D. Robertson, I. Schatz, G.K. Wenning, Consensus statement on the diagnosis of multiple system atrophy. J. Auton. Nerv. Syst. 74, 189–192 (1998)

    CAS  PubMed  Google Scholar 

  60. I. Araki, S. Kuno, Assessment of voiding dysfunction in Parkinson’s disease by the international prostate symptom score. J. Neurol. Neurosurg. Psychiatry 68, 429–433 (2000)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. G.E. Lemack, R.B. Dewey, C.G. Roehrborn, P.E. O’Suilleabhain, P.E. Zimmern, Questionnaire-based assessment of bladder dysfunction in patients with mild to moderate Parkinson’s disease. Urology 56, 250–254 (2000)

    Article  CAS  PubMed  Google Scholar 

  62. R.N. Campos-Sousa, E. Quagliato, B.B. da Silva, C.R. De Jr., S.C. Ribeiro, D.F. de Carvalho, Urinary symptoms in Parkinson’s disease: Prevalence and associated factors. Arq. Neuropsiquiatr. 61, 359–363 (2003)

    Article  PubMed  Google Scholar 

  63. I. Araki, M. Kitahara, T. Oida, S. Kuno, Voiding dysfunction and parkinson’s disease: Urodynamic abnormalities and urinary symptoms. J. Urol. 164, 1640–1643 (2000)

    Article  CAS  PubMed  Google Scholar 

  64. F. Stocchi, A. Carbone, M. Inghilleri, A. Monge, S. Ruggieri, A. Berardelli, M. Manfredi, Urodynamic and neurophysiological evaluation in Parkinson’s disease and multiple system atrophy. J. Neurol. Neurosurg. Psychiatry 62, 507–511 (1997)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. R. Sakakibara, T. Hattori, T. Uchiyama, T. Yamanishi, Videourodynamic and sphincter motor unit potential analyses in Parkinson’s disease and multiple system atrophy. J. Neurol. Neurosurg. Psychiatry 71, 600–606 (2001)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. A.J. Pavlakis, M.B. Siroky, I. Goldstein, R.J. Krane, Neurourologic findings in Parkinson’s disease. J. Urol. 129, 80–83 (1983)

    Article  CAS  PubMed  Google Scholar 

  67. H. Fitzmaurice, C.J. Fowler, D. Rickards, R.S. Kirby, N.P. Quinn, C.D. Marsden, E.J. Milroy, R.T. Turner-Warwick, Micturition disturbance in Parkinson’s disease. Br. J. Urol. 57, 652–656 (1985)

    Article  CAS  PubMed  Google Scholar 

  68. T. Uchiyama, R. Sakakibara, T. Hattori, Lower urinary tract dysfunctions of Parkinson’s disease model rat (6-hydroxydopamine treated rat) and effects of drugs. Auton. Nerv. Syst. 43, 302–308 (2006) (in Japanese, review with clinical data)

    Google Scholar 

  69. G. Palleschi, A.L. Pastore, F. Stocchi, G. Bova, M. Inghilleri, S. Sigala, A. Carbone, Correlation between the Overactive Bladder questionnaire (OAB-q) and urodynamic data of Parkinson disease patients affected by neurogenic detrusor overactivity during antimuscarinic treatment. Clin. Neuropharmacol. 29, 220–229 (2006)

    Article  PubMed  Google Scholar 

  70. T. Yamamoto, R. Sakakibara, T. Uchiyama, Z. Liu, T. Ito, Y. Awa, T. Yamanishi, T. Hattori, Neurological diseases that cause detrusor hyperactivity with impaired contractile function. Neurourol. Urodyn. 25, 356–360 (2006)

    Article  PubMed  Google Scholar 

  71. N.T. Galloway, Urethral sphincter abnormalities in parkinsonism. Br. J. Urol. 55, 691–693 (1983)

    Article  CAS  PubMed  Google Scholar 

  72. V.A. Chandiramani, J. Palace, C.J. Fowler, How to recognize patients with parkinsonism who should not have urological surgery. Br. J. Urol. 80, 100–104 (1997)

    Article  CAS  PubMed  Google Scholar 

  73. S.S. O’Sullivan, J.L. Holton, L.A. Massey, D.R. Williams, T. Revesz, A.J. Lees, Parkinson’s disease with Onuf’s nucleus involvement mimicking multiple system atrophy. J. Neurol. Neurosurg. Psychiatry 79, 232–234 (2008)

    Article  PubMed  Google Scholar 

  74. I.G. McKeith, D.W. Dickson, J. Lowe, M. Emre, J.T. O’Brien, H. Feldman, J. Cummings, J.E. Duda, C. Lippa, E.K. Perry, D. Aarsland, H. Arai, C.G. Ballard, B. Boeve, D.J. Burn, D. Costa, T. Del Ser, B. Dubois, D. Galasko, S. Gauthier, C.G. Goetz, E. Gomez-Tortosa, G. Halliday, L.A. Hansen, J. Hardy, T. Iwatsubo, R.N. Kalaria, D. Kaufer, R.A. Kenny, A. Korczyn, K. Kosaka, V.M. Lee, A. Lees, I. Litvan, E. Londos, O.L. Lopez, S. Minoshima, Y. Mizuno, J.A. Molina, E.B. Mukaetova-Ladinska, F. Pasquier, R.H. Perry, J.B. Schulz, J.Q. Trojanowski, M. Yamada, Consortium on DLB, Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium. Neurology 65, 1863–1872 (2005)

    Article  CAS  PubMed  Google Scholar 

  75. F. Tateno, R. Sakakibara, T. Ogata, M. Kishi, Y. Tsuyusaki, O. Takahashi, M. Sugiyama, A. Tateno, Lower urinary tract function in dementia with Lewy bodies (DLB). Mov. Disord. 30, 411–415 (2015)

    Article  PubMed  Google Scholar 

  76. J.C. Routh, C.R. Crimmins, B.C. Leibovich, D.S. Elliott, Impact of Parkinson’s disease on continence after radical prostatectomy. Urology 68, 575–577 (2006)

    Article  PubMed  Google Scholar 

  77. B. Roth, U.E. Studer, C.J. Fowler, T.M. Kessler, Benign prostatic obstruction and parkinson’s disease – should transurethral resection of the prostate be avoided? J. Urol. 181, 2209–2213 (2009)

    Article  PubMed  Google Scholar 

  78. C. Magerkurth, R. Schnitzer, S. Braune, Symptoms of autonomic failure in Parkinson’s disease: Prevalence and impact on daily life. Clin. Auton. Res. 15, 76–82 (2005)

    Article  PubMed  Google Scholar 

  79. H. Matsui, K. Nishinaka, M. Oda, K. Komatsu, T. Kubori, F. Udaka, Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinson’s disease correlate with major autonomic symptoms? Parkinsonism Relat. Disord. 12, 284–288 (2006)

    Article  PubMed  Google Scholar 

  80. Y. Balash, C. Peretz, G. Leibovich, T. Herman, J.M. Hausdorff, N. Giladi, Falls in outpatients with Parkinson’s disease: Frequency, impact and identifying factors. J. Neurol. 252, 1310–1315 (2005)

    Article  CAS  PubMed  Google Scholar 

  81. K. Terayama, R. Sakakibara, A. Ogawa, H. Haruta, T. Akiba, T. Nagao, O. Takahashi, M. Sugiyama, A. Tateno, F. Tateno, M. Yano, M. Kishi, Y. Tsuyusaki, T. Uchiyama, T. Yamamoto, Weak detrusor contractility correlates with motor disorders in Parkinson’s disease. Mov. Disord. 27, 1775–1780 (2012)

    Article  PubMed  Google Scholar 

  82. R.N. Campos-Sousa, I. Araújo de Sousa, K. James Almeida, I. Augusto Dias de Castro, M. Cosme Soares de Oliveira-Filho, E. M A B Quagliato, Longitudinal analysis of functional disabilities, cognitive decline and risk of dementia in women with Parkinson’s disease and detrusor overactivity. J. Clin. Neurosci. 75, 85–88 (2020)

    Article  PubMed  Google Scholar 

  83. H. Haruta, R. Sakakibara, T. Ogata, F. Tateno, M. Kishi, Y. Aiba, T. Uchiyama, T. Yamamoto, Frontal executive function and the bladder: A study of dementia with Lewy bodies. Neurol. Clin. Neurosci. 7, 22–25. First published: 01 October 2018 (2018). https://doi.org/10.1111/ncn3.12237

    Article  Google Scholar 

  84. Z. Tkaczynska, S. Becker, W. Maetzler, M. Timmers, L. Van Nueten, P. Sulzer, G. Salvadore, E. Schäffer, K. Brockmann, J. Streffer, D. Berg, I. Liepelt-Scarfone, Executive function is related to the urinary urgency in non-demented patients With Parkinson’s disease. Front. Aging Neurosci. 12, 55 (2020). https://doi.org/10.3389/fnagi.2020.00055. eCollection 2020

    Article  PubMed  PubMed Central  Google Scholar 

  85. R. Sakakibara, F.C. Lee, H. Suzuki, F. Tateno, M. Kishi, Y. Aiba, Parkinson’s disease and prostate enlargement: Both contribute to overactive bladder in the elderly. Int. J. Urol. 25, 982–983 (2018)

    Article  PubMed  Google Scholar 

  86. R. Sakakibara, T. Ogata, Y. Aiba, F. Tateno, T. Uchiyama, T. Yamamoto, Does depression contribute to the bladder and bowel complaint in Parkinson’s disease patients? Mov. Disord. Clin. Pract. 8, 240–244 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  87. S. Kuno, E. Mizuta, S. Yamasaki, I. Araki, Effects of pergolide on nocturia in Parkinson’s disease: Three female cases selected from over 400 patients. Parkinsonism Relat. Disord. 10, 181–187 (2004)

    Article  PubMed  Google Scholar 

  88. R. Sakakibara, F. Tateno, T. Nagao, T. Yamamoto, T. Uchiyama, T. Yamanishi, M. Yano, M. Kishi, Y. Tsuyusaki, Y. Aiba, Bladder function of patients with Parkinson’s disease. Int. J. Urol. 21, 638–646 (2014)

    Article  CAS  PubMed  Google Scholar 

  89. T. Uchiyama, R. Sakakibara, M. Yoshiyama, T. Yamamoto, T. Ito, Z. Liu, C. Yamaguchi, Y. Awa, H.M. Yano, M. Yanagisawa, T. Yamanishi, T. Hattori, S. Kuwabara, Biphasic effect of apomorphine, an anti-parkinsonian drug, on bladder function in rats. Neuroscience 162, 1333–1338 (2009)

    Article  CAS  PubMed  Google Scholar 

  90. L. Brusa, F. Petta, A. Pisani, V. Moschella, C. Iani, P. Stanzione, R. Miano, E. Finazzi-Agrò, Acute vs chronic effects of L-dopa on bladder function in patients with mild Parkinson disease. Neurology 68, 1455–1459 (2007)

    Article  CAS  PubMed  Google Scholar 

  91. T. Uchiyama, R. Sakakibara, T. Yamamoto, T. Ito, C. Yamaguchi, Y. Awa, M. Yano, M. Yanagisawa, M. Kobayashi, Y. Higuchi, T. Ichikawa, T. Yamanishi, T. Hattori, S. Kuwabara, Comparing bromocriptine effects with levodopa effects on bladder function in Parkinson’s disease. Mov. Disord. 24, 2386–2390 (2009)

    Article  PubMed  Google Scholar 

  92. L. Brusa, S. Musco, G. Bernardi, C. Iani, M. Pierantozzi, P. Stanzione, A. Stefani, Finazzi Agro’ E Rasagiline effect on bladder disturbances in early mild Parkinson’s disease patients. Parkinsonism Relat. Disord. 20, 931–932 (2014)

    Article  CAS  PubMed  Google Scholar 

  93. T. Kitta, I. Yabe, Y. Kanno, M. Higuchi, M. Ouchi, M. Togo, K. Moriya, I. Takahashi, M. Matsushima, H. Sasaki, N. Shinohara, Long-term outcome of adenosine A2A receptor antagonist on lower urinary tract symptoms in male Parkinson disease patients. Clin. Neuropharmacol. 41, 98–102 (2018)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. L. Brusa, V. Ponzo, A. Stefani, R. Ceravolo, G. Palermo, E.F. Agrò, F. Viselli, M.C. Altavista, C. Iani, F. Stocchi, P. Stanzione, C. Vitale, Extended release levodopa at bedtime as a treatment for nocturiain Parkinson’s disease: An open label study. J. Neurol. Sci. 410, 116625 (2020). https://doi.org/10.1016/j.jns.2019.116625. Epub 2019 Dec 16

    Article  CAS  PubMed  Google Scholar 

  95. P. Abrams, K.E. Andersson, J.J. Buccafusco, C. Chapple, W.C. de Groat, A.D. Fryer, G. Kay, A. Laties, N.M. Nathanson, P.J. Pasricha, A.J. Wein, Muscarinic receptors: Their distribution and function in body systems, and the implications for treating overactive bladder. Br. J. Pharmacol. 148, 565–578 (2006)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. C.A. Donnellan, L. Fook, P. McDonald, J.R. Playfer, Oxybutynin and cognitive dysfunction. BMJ 315, 1363–1364 (1997)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. R. Sakakibara, T. Uchiyama, T. Yamanishi, M. Kishi, Dementia and lower urinary dysfunction: With a reference to anticholinergic use in elderly population. Int. J. Urol. 15, 778–788 (2008)

    Google Scholar 

  98. T. Yonguc, E. Sefik, I. Inci, O.Y. Kusbeci, S. Celik, M.E. Aydın, S. Polat, Randomized, controlled trial of fesoterodine fumarate for overactive bladder in Parkinson’s disease. World J. Urol. 38, 2013–2019 (2020)

    Article  CAS  PubMed  Google Scholar 

  99. M. Kono, Y. Nakamura, Y. Ishiura, K. Komatsu, H. Kontani, M. Namiki, Central muscarinic receptor subtypes regulating voiding in rats. J. Urol. 175, 353–357 (2006)

    Article  CAS  PubMed  Google Scholar 

  100. R. Sakakibara, T. Uchiyama, M. Yoshiyama, T. Yamanishi, T. Hattori, Preliminary communication: urodynamic assessment of donepezil hydrochloride in patients with Alzheimer’s disease. Neurourol. Urodyn. 24, 273–275 (2005)

    Article  CAS  PubMed  Google Scholar 

  101. R. Sakakibara, T. Ogata, T. Uchiyama, M. Kishi, E. Ogawa, S. Isaka, J. Yuasa, T. Yamamoto, T. Ito, T. Yamanishi, Y. Awa, C. Yamaguchi, O. Takahashi, How to manage overactive bladder in elderly individuals with dementia? A combined use of donepezil, a central AChE inhibitor, and propiverine, a peripheral muscarine receptor antagonist. J. Am. Geriatr. Soc. 57, 1515–1517 (2009)

    Article  PubMed  Google Scholar 

  102. B. Peyronnet, G. Vurture, J.A. Palma, D.R. Malacarne, A. Feigin, R.D. Sussman, M.C. Biagioni, R. Palmerola, R. Gilbert, N. Rosenblum, S. Frucht, H. Kaufmann, V.W. Nitti, B.M. Brucker, Mirabegron in patients with Parkinson disease and overactive bladder symptoms: A retrospective cohort. Parkinsonism Relat. Disord. 57, 22–26 (2018)

    Article  PubMed  Google Scholar 

  103. M. Gubbiotti, A. Conte, S.M. Di Stasi, N. Tambasco, A. Giannantoni, Feasibility of mirabegron in the treatment of overactive bladder in patients affected by Parkinson’s disease: A pilot study. Ther. Adv. Neurol. Disord. 12, 1756286419843458 (2019). https://doi.org/10.1177/1756286419843458. eCollection 2019

    Article  PubMed  PubMed Central  Google Scholar 

  104. S.Y. Cho, S.J. Jeong, S. Lee, J. Kim, S.H. Lee, M.S. Choo, S.J. Oh, Mirabegron for treatment of overactive bladder symptoms in patients with Parkinson’s disease: A double-blind, randomized placebo-controlled trial (Parkinson’s Disease Overactive bladder Mirabegron, PaDoMi Study). Neurourol. Urodyn. 40, 286–294 (2021)

    Article  PubMed  Google Scholar 

  105. A. Kanai, I. Zabbarova, M. Oefelein, P. Radziszewski, Y. Ikeda, K.E. Andersson, Mechanisms of action of botulinum neurotoxins, β3-adrenergic receptor agonists, and PDE5 inhibitors in modulating detrusor function in overactive bladders: ICI-RS 2011. Neurourol. Urodyn. 31, 300–308 (2012)

    Article  CAS  PubMed  Google Scholar 

  106. S. Proietti, A. Giannantoni, A. Sahai, M.S. Khan, P. Dasgupta, Overactive bladder and sexual function: A nightmare couple. BJU Int. 110, 921–924 (2012)

    Article  PubMed  Google Scholar 

  107. M. Quik, S. Wonnacott, 62 and 42 nicotinic acetylcholine receptors as drug targets for Parkinson’s disease. Pharmacol. Rev. 63, 938–966 (2011)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. A. Fink-Jensen, L.S. Schmidt, D. Dencker, C. Schülein, J. Wess, G. Wörtwein, D.P. Woldbye, Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor. Eur. J. Pharmacol. 656, 39–44 (2011)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. K. Haraguchi, K. Ito, H. Kotaki, Y. Sawada, T. Iga, Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies. Drug Metab. Dispos. 25, 675–684 (1997)

    CAS  PubMed  Google Scholar 

  110. R.A. Hauser, C.W. Olanow, Orobuccal dyskinesia associated with trihexyphenidyl therapy in a patient with Parkinson’s disease. Mov. Disord. 8, 512–514 (1993)

    Article  CAS  PubMed  Google Scholar 

  111. H. Matsuo, A. Matsui, R. Nasu, H. Takanaga, N. Inoue, F. Hattori, H. Ohtani, Y. Sawada, Propiverine-induced parkinsonism: A case report and a pharmacokinetic/pharmacodynamic study in mice. Pharm. Res. 17, 565–571 (2000)

    Article  CAS  PubMed  Google Scholar 

  112. Y. Yoshiyama, A. Kojima, K. Itoh, T. Uchiyama, K. Arai, Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model. Neurobiol. Dis. 45, 329–336 (2012)

    Article  CAS  PubMed  Google Scholar 

  113. T. Ito, R. Sakakibara, K. Nakazawa, T. Uchiyama, T. Yamamoto, Z. Liu, E. Shimizu, T. Hattori, Effects of electrical stimulation of the raphe area on the micturition reflex in cats. Neuroscience 142, 1273–1280 (2006)

    Article  CAS  PubMed  Google Scholar 

  114. G.M. Halliday, P.C. Blumbergs, R.G. Cotton, W.W. Blessing, L.B. Geffen, Loss of brainstem serotonin- and substance P-containing neurons in Parkinson’s disease. Brain Res. 510, 104–107 (1990)

    Article  CAS  PubMed  Google Scholar 

  115. R. Sakakibara, T. Ito, T. Uchiyama, Y. Awa, C. Yamaguchi, T. Hattori, Effects of milnacipran and paroxetine on overactive bladder due to neurologic diseases: A urodynamic assessment. Urol. Int. 81, 335–339 (2008)

    Article  CAS  PubMed  Google Scholar 

  116. T. Hineno, M. Mizobuchi, K. Hiratani, Y. Inami, Y. Kakimoto, Disappearance of circadian rhythms in Parkinson’s disease model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in dogs. Brain Res. 580, 92–99 (1992)

    Article  CAS  PubMed  Google Scholar 

  117. O. Suchowersky, S. Furtado, G. Rohs, Beneficial effect of intranasal desmopressin for nocturnal polyuria in Parkinson’s disease. Mov. Disord. 10, 337–340 (1995)

    Article  CAS  PubMed  Google Scholar 

  118. A. Batla, S. Simeoni, T. Uchiyama, L. deMin, J. Baldwin, C. Melbourne, S. Islam, K.P. Bhatia, M. Pakzad, S. Eriksson, J.N. Panicker, Exploratory pilot study of exogenous sustained-release melatonin on nocturia in Parkinson’s disease. Eur. J. Neurol. (2021). https://doi.org/10.1111/ene.14774. Online ahead of print

  119. J.O. Dostrovsky, A.M. Lozano, Mechanisms of deep brain stimulation. Mov. Disord. 17(Suppl 3), S63–S68 (2002)

    Article  PubMed  Google Scholar 

  120. E. Finazzi-Agro, A. Peppe, A. d’Amico, F. Petta, P. Mazzone, P. Stanzione, F. Micali, C. Caltagirone, Effects of subthalamic nucleus stimulation on urodynamic findings in patients with Parkinson’s disease. J. Urol. 169, 1388–1391 (2003)

    Article  PubMed  Google Scholar 

  121. C. Seif, J. Herzog, H.C. van der, B. Schrader, J. Volkmann, G. Deuschl, K.P. Juenemann, P.M. Braun, Effect of subthalamic deep brain stimulation on the function of the urinary bladder. Ann. Neurol. 55, 118–120 (2004)

    Article  PubMed  Google Scholar 

  122. K. Winge, K.K. Nielsen, H. Stimpel, A. Lokkegaard, S.R. Jensen, L. Werdelin, Lower urinary tract symptoms and bladder control in advanced Parkinson’s disease: Effects of deep brain stimulation in the subthalamic nucleus. Mov. Disord. 22, 220–225 (2007)

    Article  PubMed  Google Scholar 

  123. H.M. Fritsche, R. Ganzer, J. Schlaier, W.F. Wieland, A. Brawanski, M. Lange, Acute urinary retention in two patients after subthalamic nucleus deep brain stimulation (STN-DBS) for the treatment of advanced Parkinson’s disease. Mov. Disord. 24, 1553–1554 (2009)

    Article  PubMed  Google Scholar 

  124. S.C. Kabay, S. Kabay, M. Yucel, H. Ozden, Acute urodynamic effects of percutaneous posterior tibial nerve stimulation on neurogenic detrusor overactivity in patients with Parkinson’s disease. Neurourol. Urodyn. 28, 62–67 (2009)

    Article  PubMed  Google Scholar 

  125. D. McClurg, J. Panicker, R.W. Walker, A. Cunnington, K.H.O. Deane, D. Harari, A. Elders, J. Booth, S. Hagen, H. Mason, S. Stratton, Stimulation of the tibial nerve: a protocol for a multicentred randomised controlled trial for urinary problems associated with Parkinson’s disease-STARTUP. BMJ Open 10(2), e034887 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  126. T.G. Araujo, A.P. Schmidt, P.R.S. Sanches, D.P. Silva Junior, C.R.M. Rieder, J.G.L. Ramos, Transcutaneous tibial nerve home stimulation for overactive bladder in women with Parkinson’s disease: A randomized clinical trial. Neurourol. Urodyn. 40, 538–548 (2021)

    Article  PubMed  Google Scholar 

  127. L. Brusa, E. Finazzi Agrò, F. Petta, F. Sciobica, S. Torriero, E. Lo Gerfo, C. Iani, P. Stanzione, G. Koch, Effects of inhibitory rTMS on bladder function in Parkinson’s disease patients. Mov. Disord. 24, 445–448 (2009)

    Article  PubMed  Google Scholar 

  128. A. Giannantoni, A. Rossi, E. Mearini, M. Del Zingaro, M. Porena, A. Berardelli, Botulinum toxin A for overactive bladder and detrusor muscle overactivity in patients with Parkinson’s disease and multiple system atrophy. J. Urol. 182, 1453–1457 (2009)

    Article  PubMed  Google Scholar 

  129. H. Kulaksizoglu, Y. Parman, Use of botulinum toxin-A for the treatment of overactive bladder symptoms in patients with Parkinson’s disease. Parkinsonism Relat. Disord. 16, 531–534 (2010)

    Article  PubMed  Google Scholar 

  130. G. Vurture, B. Peyronnet, A. Feigin, M.C. Biagioni, R. Gilbert, N. Rosenblum, S. Frucht, A. Di Rocco, V.W. Nitti, B.M. Brucker, Outcomes of intradetrusor onabotulinum toxin A injection in patients with Parkinson’s disease. Neurourol. Urodyn. 37, 2669–2677 (2018)

    Article  CAS  PubMed  Google Scholar 

  131. D.R. Greenberg, E.M. Sohlberg, C.A. Zhang, V.E. Santini, C.V. Comiter, E.A. Enemchukwu, Sacral nerve stimulation in Parkinson’s disease patients with overactive bladder symptoms. Urology 144, 99–105 (2020)

    Article  PubMed  Google Scholar 

  132. R. Sakakibara, J. Panicker, E. Finazzi-Agro, et al., A guideline for the management of bladder dysfunction in Parkinson’s disease and other gait disorders. Neurourol. Urodyn. 35, 551–563 (2016)

    Article  PubMed  Google Scholar 

  133. C.P. Vaughan, J.L. Juncos, K.L. Burgio, P.S. Goode, R.A. Wolf, T.M. Johnson 2nd, Behavioral therapy to treat urinary incontinence in Parkinson disease. Neurology 76, 1631–1634 (2011)

    Article  CAS  PubMed  Google Scholar 

  134. C.P. Vaughan, K.L. Burgio, P.S. Goode, J.L. Juncos, G. McGwin, L. Muirhead, A.D. Markland, T.M. Johnson 2nd, Behavioral therapy for urinary symptoms in Parkinson’s disease: A randomized clinical trial. Neurourol. Urodyn. 38, 1737–1744 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  135. C. McDonald, J. Rees, K. Winge, J.L. Newton, D.J. Burn, Bladder training for urinary tract symptoms in Parkinson disease: A randomized controlled trial. Neurology 94, e1427–e1433 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

  136. D. Duncan, Role of the community nurse in Parkinson’s disease and lower urinary disorders. Br. J. Community Nurs. 26, 251–254 (2021)

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurology, Neurology Clinic Tsudanuma & Dowakai Chiba Hospital, Funabashi, Japan

    Ryuji Sakakibara

  2. Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan

    Tatsuya Yamamoto

  3. Neurology, Chiba Prefectural University of Health Sciences, Chiba, Japan

    Tatsuya Yamamoto

  4. Neurology, International University of Health and Welfare, Narita, Japan

    Tomoyuki Uchiyama

Authors
  1. Ryuji Sakakibara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tatsuya Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomoyuki Uchiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ryuji Sakakibara .

Editor information

Editors and Affiliations

  1. Department of Urology Department of Neurourology, China Rehabiliation Research Center China Rehabilitation Science InstituteCapital Medical University, Beijing, China

    Limin Liao

  2. Department of Urology, Medical University Innsbruck, University Hospital, Innsbruck, Austria

    Helmut Madersbacher

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer Nature Singapore Pte Ltd.

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Sakakibara, R., Yamamoto, T., Uchiyama, T. (2023). Parkinson’s Disease. In: Liao, L., Madersbacher, H. (eds) Handbook of Neurourology. Springer, Singapore. https://doi.org/10.1007/978-981-99-1659-7_60

Download citation

  • DOI: https://doi.org/10.1007/978-981-99-1659-7_60

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-1658-0

  • Online ISBN: 978-981-99-1659-7

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation