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Botulinum Toxin and the Bladder: Future Research Directions

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Handbook of Neurourology

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Abstract

As the intradetrusor injections of BoNT/A remain a minimally invasive with associated patient discomfort and transient injection-related complications, several novel injection-free techniques are being tested in preclinical and clinical studies. These aim at passive diffusion (plain intravesical instillation), disrupting the urothelial barrier (protamine sulfate, dimethyl sulfoxide), increasing urothelial permeability (electromotive drug administration – EMDA, low-energy shock waves – LESW), or transportation via new carrier formulations (liposomes+BoNT/A, thermosensitive hydrogel+BoNT/A, hyaluronic acid+phosphatidylethanolamine+ BoNT/A). Promising, albeit short-lived, results have been reported in small non-neurogenic OAB and interstitial cystitis/bladder pain syndrome studies mostly, with only reports with EMDA existing in neurogenic populations to-date.

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Authors and Affiliations

  1. 2nd Department of Urology, Aristotle University of Thessaloniki, General Hospital ‘Papageorgiou’, Thessaloniki, Greece

    Sotirios Gatsos & Apostolos Apostolidis

Authors
  1. Sotirios Gatsos
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  2. Apostolos Apostolidis
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Corresponding author

Correspondence to Apostolos Apostolidis .

Editor information

Editors and Affiliations

  1. Department of Urology Department of Neurourology, China Rehabiliation Research Center China Rehabilitation Science InstituteCapital Medical University, Beijing, China

    Limin Liao

  2. Department of Urology, Medical University Innsbruck, University Hospital, Innsbruck, Austria

    Helmut Madersbacher

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Gatsos, S., Apostolidis, A. (2023). Botulinum Toxin and the Bladder: Future Research Directions. In: Liao, L., Madersbacher, H. (eds) Handbook of Neurourology. Springer, Singapore. https://doi.org/10.1007/978-981-99-1659-7_34

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  • DOI: https://doi.org/10.1007/978-981-99-1659-7_34

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-1658-0

  • Online ISBN: 978-981-99-1659-7

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