Encyclopedia of Geropsychology

2017 Edition
| Editors: Nancy A. Pachana

Depression and Cognition

  • Rowena GomezEmail author
  • Garima Jhingon
Reference work entry
DOI: https://doi.org/10.1007/978-981-287-082-7_361

Synonyms

Mood disorder; Neuropsychology
Depression

A psychiatric disorder that includes symptoms of sad mood, hopelessness, poor sleep and appetite, guilt or worthlessness, low energy, and severe suicidal thoughts

Cognition

Thinking skills or abilities that include attention, processing speed, working memory, language, visuospatial skills, language, and executive functioning

Introduction

As an age group, older adults have a smaller prevalence rate for depression compared to middle-aged adults that continues to decrease with advancing age (e.g., Byers et al. 2010). Although the prevalence of depression is lower with older age, the effects of depression in the daily life of patients may be greater with advancing age due to other factors that make older adults a more vulnerable population (e.g., decrease in physical health, cognitive changes due to normal aging, comorbidity with other health/mental health disorders). In particular, cognitive declines due to age-related changes in the...

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References

  1. Alexopoulos, G. S., & Meyers, B. S. (1993). The course of geriatric depression with “reversible dementia”: A controlled study. The American Journal of Psychiatry, 150(11), 1693.PubMedCrossRefGoogle Scholar
  2. Bali, V., Holmes, H. M., Johnson, M. L., Chen, H., Fleming, M. L., & Aparasu, R. R. (2016). Comparative effectiveness of second-generation antidepressants in reducing the risk of dementia in elderly nursing home residents with depression. Pharmacotherapy, 36(1), 38–48.PubMedCrossRefGoogle Scholar
  3. Burt, T., Prudic, J., Peyser, S., Clark, J., & Sackeim, H. A. (2000). Learning and memory in bipolar and unipolar major depression: Effects of aging. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 13, 246–253.PubMedGoogle Scholar
  4. Butters, M. A., Whyte, E. M., Nebes, R. D., Begley, A. E., Dew, M. A., Mulsant, B. H., Zmuda, M. D., Bhalla, R., Meltzer, C. C., Pollock, B. G., Reynolds, C. F., III, & Becker, J. T. (2004). The nature and determinants of neuropsychological functioning in late-life depression. Archives of General Psychiatry, 61(6), 587–595.PubMedCrossRefGoogle Scholar
  5. Byers, A. L., & Yaffe, K. (2011). Depression and risk of developing dementia. Nature Reviews. Neurology, 7(6), 323–331.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Byers, A. L., Yaffe, K., Covinsky, K. E., Friedman, M. B., & Bruce, M. L. (2010). High occurrence of mood and anxiety disorders among older adults: The National Comorbidity Survey Replication. Archives of General Psychiatry, 67(5), 489–496.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Culang, M. E., Sneed, J. R., Keilp, J. G., Rutherford, B. R., Pelton, G. H., Devanand, D. P., & Roose, S. P. (2009). Change in cognitive functioning following acute antidepressant treatment in late-life depression. The American Journal of Geriatric Psychiatry, 17(10), 881–888.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Diniz, B. S., Butters, M. A., Albert, S. M., Dew, M. A., & Reynolds, C. F. (2013). Late-life depression and risk of vascular dementia and Alzheimer’s disease: Systematic review and meta-analysis of community-based cohort studies. The British Journal of Psychiatry, 202(5), 329–335.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Doraiswamy, P. M., Krishnan, K. R., Oxman, T., et al. (2003). Does antidepressant therapy improve cognition in elderly depressed patients? The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 58, M1137–M1144.PubMedCrossRefGoogle Scholar
  10. Dybedal, G. S., Tanum, L., Sundet, K., Gaarden, T. L., & Bjølseth, T. M. (2013). Neuropsychological functioning in late-life depression. Frontiers in Psychology, 4, 381.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Elderkin-Thompson, V., Mintz, J., Haroon, E., Lavretsky, H., & Kumar, A. (2007). Executive dysfunction and memory in older patients with major and minor depression. Archives of Clinical Neuropsychology, 22, 261–270.PubMedCrossRefGoogle Scholar
  12. Ellen, M., & David, C. (2010). Understanding depression and cognitive impairment in the elderly. Psychiatric Annals, 40(1), 29–40.CrossRefGoogle Scholar
  13. Herrmann, L. L., Goodwin, G. M., & Ebmeier, K. P. (2007). The cognitive neuropsychology of depression in the elderly. Psychological Medicine, 37, 1693–1702.PubMedCrossRefGoogle Scholar
  14. Hofman, M., Seifritz, E., Kräuchi, K., Hock, C., Hampel, H., Neugebauer, A., & Müller-Spahn, F. (2000). Alzheimer’s disease, depression and normal ageing: Merit of simple psychomotor and visuospatial tasks. International Journal of Geriatric Psychiatry, 15(1), 31–39.PubMedCrossRefGoogle Scholar
  15. Kang, H., Zhao, F., You, L., & Giorgetta, C. (2014). Pseudo-dementia: A neuropsychological review. Annals of Indian Academy of Neurology, 17(2), 147–154.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Köhler, S., Thomas, A. J., Barnett, N. A., & O’Brien, J. T. (2010). The pattern and course of cognitive impairment in late-life depression. Psychological Medicine, 40(4), 591–602.PubMedCrossRefGoogle Scholar
  17. Lee, J. S., Potter, G. G., Wagner, H. R., Welsh-Bohmer, K. A., & Steffens, D. C. (2007). Persistent mild cognitive impairment in geriatric depression. International Psychogeriatrics, 19(1), 125–135.PubMedCrossRefGoogle Scholar
  18. Lockwood, K. A., Alexopoulos, G. S., & van Gorp, W. G. (2002). Executive dysfunction in geriatric depression. American Journal of Psychiatry, 159, 1119–1126.PubMedCrossRefGoogle Scholar
  19. Mesholam-Gately, R. I., Giuliano, A. J., Zillmer, E. A., Barakat, L. P., Kumar, A., Gur, R. C., … & Moberg, P. J. (2012). Verbal learning and memory in older adults with minor and major depression. Archives of clinical neuropsychology, 27(2), 196–207.Google Scholar
  20. Nebes, R. D., Butters, M. A., Mulsant, B. H., Pollock, B. G., Zmuda, M. D., Houck, P. R., & Reynolds, C. F. (2000). Decreased working memory and processing speed mediate cognitive impairment in geriatric depression. Psychological Medicine, 30(3), 679–691.PubMedCrossRefGoogle Scholar
  21. Nebes, R. D., Pollock, B. G., Houck, P. R., et al. (2003). Persistence of cognitive impairment in geriatric patients following antidepressant treatment: A randomized, double-blind clinical trial with nortriptyline and paroxetine. Journal of Psychiatric Research, 37, 99–108.PubMedCrossRefGoogle Scholar
  22. Pantzar, A., Laukka, E. J., Atti, A. R., Fastbom, J., Fratiglioni, L., & Bäckman, L. (2014). Cognitive deficits in unipolar old-age depression: A population-based study. Psychological Medicine, 44(05), 937–947.PubMedCrossRefGoogle Scholar
  23. Panza, F., Frisardi, V., Capurso, C., D’Introno, A., Colacicco, A. M., Imbimbo, B. P., … & Capurso, A. (2010). Late-life depression, mild cognitive impairment, and dementia: Possible continuum?. The American Journal of Geriatric Psychiatry, 18(2), 98–116.Google Scholar
  24. Rapp, M. A., Dahlman, K., Sano, M., Grossman, H. T., Haroutunian, V., & Gorman, J. M. (2005). Neuropsychological differences between late-onset and recurrent geriatric major depression. The American Journal of Psychiatry, 162(4), 691–698.PubMedCrossRefGoogle Scholar
  25. Rosenberg, P. B., Mielke, M. M., Xue, Q. L., & Carlson, M. C. (2010). Depressive symptoms predict incident cognitive impairment in cognitive healthy older women. The American Journal of Geriatric Psychiatry, 18(3), 204–211.PubMedPubMedCentralCrossRefGoogle Scholar
  26. Saczynski, J. S., Rosen, A. B., McCammon, R. J., Zivin, K., Andrade, S. E., Langa, K. M., Vijan, S., Pirraglia, P. A., & Briesacher, B. A. (2015). Antidepressant use and cognitive decline: The health and retirement study. The American Journal of Medicine, 128(7), 739–746.PubMedPubMedCentralCrossRefGoogle Scholar
  27. Salthouse, T. A. (1996). The processing-speed theory of adult age differences in cognition. Psychological Review, 103, 403–428.PubMedCrossRefGoogle Scholar
  28. Sheline, Y. I., Barch, D. M., Garcia, K., Gersing, K., Pieper, C., Welsh-Bohmer, K., Steffens, D. C., & Doraiswamy, P. M. (2006). Cognitive function in late life depression: Relationships to depression severity, cerebrovascular risk factors and processing speed. Biological Psychiatry, 60(1), 58–65.PubMedCrossRefGoogle Scholar
  29. Sneed, J. R., & Culang-Reinlieb, M. E. (2011). The vascular depression hypothesis: An update. The American Journal of Geriatric Psychiatry, 19(2), 99–103.PubMedPubMedCentralCrossRefGoogle Scholar
  30. Thomas, A. J., & O’Brien, J. T. (2008). Depression and cognition in older adults. Current Opinion In Psychiatry, 21(1), 8–13.PubMedCrossRefGoogle Scholar
  31. Tzang, R. F., Yang, A. C., Yeh, H. L., Liu, M. E., & Tsai, S. J. (2015). Association of depression and loneliness with specific cognitive performance in non-demented elderly males. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 21, 100–104.CrossRefGoogle Scholar
  32. van den Kommer, T. N., Comijs, H. C., Aartsen, M. J., Huisman, M., Deeg, D. J., & Beekman, A. T. (2013). Depression and cognition: How do they interrelate in old age? The American Journal of Geriatric Psychiatry, 21(4), 398–410.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Singapore 2017

Authors and Affiliations

  1. 1.Pacific Graduate School of PsychologyPalo Alto UniversityPalo AltoUSA