Definition
Neurotrophic factors (NFs) are polypeptides involved in the maintenance and adequate function of neurons and neuron-supporting cells. Mechanisms underlying NFs signaling may fail during neuronal repair and aging, resulting in neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) (Lanni et al. 2010).
Introduction
Neurotrophic factors (NFs) are a group of soluble polypeptides with a range of functions in nervous system development and maintenance, and survival of neurons and neuron-supporting cells.
NFs are divided into different families according to structure and function: (i) neurotrophins (NTs): nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, and NT-4; (ii) transforming growth factor (TGF)-β superfamily which includes the glial-cell-line-derived neurotrophic factor (GDNF); (iii) neurokine superfamily comprising ciliary neurotrophic factor (CNTF), interleukin (IL)-6, and IL-11, among others; and (iv) nonneuronal...
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Rocha, N.P., Teixeira, A.L. (2016). Neurotrophic Factors in Aging. In: Pachana, N. (eds) Encyclopedia of Geropsychology. Springer, Singapore. https://doi.org/10.1007/978-981-287-080-3_263-1
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DOI: https://doi.org/10.1007/978-981-287-080-3_263-1
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