Encyclopedia of Geropsychology

Living Edition
| Editors: Nancy A. Pachana

Neurotrophic Factors in Aging

  • Natália Pessoa RochaEmail author
  • Antônio Lúcio Teixeira
Living reference work entry
DOI: https://doi.org/10.1007/978-981-287-080-3_263-1

Definition

Neurotrophic factors (NFs) are polypeptides involved in the maintenance and adequate function of neurons and neuron-supporting cells. Mechanisms underlying NFs signaling may fail during neuronal repair and aging, resulting in neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) (Lanni et al. 2010).

Introduction

Neurotrophic factors (NFs) are a group of soluble polypeptides with a range of functions in nervous system development and maintenance, and survival of neurons and neuron-supporting cells.

NFs are divided into different families according to structure and function: (i) neurotrophins (NTs): nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, and NT-4; (ii) transforming growth factor (TGF)-β superfamily which includes the glial-cell-line-derived neurotrophic factor (GDNF); (iii) neurokine superfamily comprising ciliary neurotrophic factor (CNTF), interleukin (IL)-6, and IL-11, among others; and (iv) nonneuronal...

Keywords

Neurotrophic factors Neurotrophins Aging Alzheimer’s disease Parkinson’s disease 
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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • Natália Pessoa Rocha
    • 1
    Email author
  • Antônio Lúcio Teixeira
    • 1
  1. 1.Laboratório Interdisciplinar de Investigação Médica, Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo HorizonteBrazil