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Neurotrophic Factors in Aging

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Encyclopedia of Geropsychology

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Definition

Neurotrophic factors (NFs) are polypeptides involved in the maintenance and adequate function of neurons and neuron-supporting cells. Mechanisms underlying NFs signaling may fail during neuronal repair and aging, resulting in neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) (Lanni et al. 2010).

Introduction

Neurotrophic factors (NFs) are a group of soluble polypeptides with a range of functions in nervous system development and maintenance, and survival of neurons and neuron-supporting cells.

NFs are divided into different families according to structure and function: (i) neurotrophins (NTs): nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, and NT-4; (ii) transforming growth factor (TGF)-β superfamily which includes the glial-cell-line-derived neurotrophic factor (GDNF); (iii) neurokine superfamily comprising ciliary neurotrophic factor (CNTF), interleukin (IL)-6, and IL-11, among others; and (iv) nonneuronal...

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References

  • Aloe, L., Rocco, M. L., Bianchi, P., & Manni, L. (2012). Nerve growth factor: From the early discoveries to the potential clinical use. Journal of Translational Medicine, 10, 239. doi:10.1186/1479-5876-10-239. Review.

    Article  Google Scholar 

  • Chakravarthy, B., Ménard, M., Ito, S., Gaudet, C., Dal Prà, I., Armato, U., & Whitfield, J. (2012). Hippocampal membrane-associated p75NTR levels are increased in Alzheimer’s disease. Journal of Alzheimer’s Disease, 30(3), 675–684.

    Google Scholar 

  • Diniz, B. S., Teixeira, A. L., Machado-Vieira, R., Talib, L. L., Gattaz, W. F., & Forlenza, O. V. (2013). Reduced serum nerve growth factor in patients with late-life depression. The American Journal of Geriatric Psychiatry, 21(5), 493–496.

    Article  Google Scholar 

  • Diniz, B. S., Teixeira, A. L., Machado-Vieira, R., Talib, L. L., Radanovic, M., Gattaz, W. F., & Forlenza, O. V. (2014). Reduced cerebrospinal fluid levels of brain-derived neurotrophic factor is associated with cognitive impairment in late-life major depression. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 69(6), 845–851.

    Article  Google Scholar 

  • Eriksdotter-Jönhagen, M., Linderoth, B., Lind, G., Aladellie, L., Almkvist, O., Andreasen, N., Blennow, K., Bogdanovic, N., Jelic, V., Kadir, A., Nordberg, A., Sundström, E., Wahlund, L. O., Wall, A., Wiberg, M., Winblad, B., Seiger, A., Almqvist, P., & Wahlberg, L. (2012). Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 33(1), 18–28.

    Article  Google Scholar 

  • Faria, M. C., Gonçalves, G. S., Rocha, N. P., Moraes, E. N., Bicalho, M. A., Gualberto Cintra, M. T., Jardim de Paula, J., José Ravic de Miranda, L. F., Clayton de Souza Ferreira, A., Teixeira, A. L., Gomes, K. B., Carvalho, M. G., & Sousa, L. P. (2014). Increased plasma levels of BDNF and inflammatory markers in Alzheimer’s disease. Journal of Psychiatric Research, 53, 166–172.

    Article  Google Scholar 

  • Forlenza, O. V., Teixeira, A. L., Miranda, A. S., Barbosa, I. G., Talib, L. L., Diniz, B. S., & Gattaz, W. F. (2015). Decreased neurotrophic support is associated with cognitive decline in non-demented subjects. Journal of Alzheimer’s Disease, 46, 423. [Epub ahead of print].

    Article  Google Scholar 

  • Frade, J. M., & Barde, Y. A. (1999). Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord. Development, 126(4), 683–690.

    Google Scholar 

  • Henderson, C. E., Phillips, H. S., Pollock, R. A., Davies, A. M., Lemeulle, C., Armanini, M., Simpson, L. C., Moffet, B., Vandlen, R. A., Koliatsos, V. E., & Rosenthal, A. (1994). GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle. Science, 266(5187), 1062–1064.

    Article  Google Scholar 

  • Huang, E. J., & Reichardt, L. F. (2001). Neurotrophins: Roles in neuronal development and function. Annual Review of Neuroscience, 24, 677–736.

    Article  Google Scholar 

  • Kalia, L. V., Kalia, S. K., & Lang, A. E. (2015). Disease-modifying strategies for Parkinson’s disease. Movement Disorders. doi:10.1002/mds.26354. [Epub ahead of print].

    Google Scholar 

  • Kao, P. F., Banigan, M. G., Vanderburg, C. R., McKee, A. C., Polgar, P. R., Seshadri, S., & Delalle, I. (2012). Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. Journal of Neuropathology and Experimental Neurology, 71(7), 654–664.

    Article  Google Scholar 

  • Karami, A., Eyjolfsdottir, H., Vijayaraghavan, S., Lind, G., Almqvist, P., Kadir, A., Linderoth, B., Andreasen, N., Blennow, K., Wall, A., Westman, E., Ferreira, D., Kristoffersen Wiberg, M., Wahlund, L. O., Seiger, Å., Nordberg, A., Wahlberg, L., Darreh-Shori, T., & Eriksdotter, M. (2015). Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer’s disease. Alzheimers Dement. doi:10.1016/j.jalz.2014.11.008. pii: S1552-5260(15)00007-2. [Epub ahead of print].

    Google Scholar 

  • Lanni, C., Stanga, S., Racchi, M., & Govoni, S. (2010). The expanding universe of neurotrophic factors: Therapeutic potential in aging and age-associated disorders. Current Pharmaceutical Design, 16(6), 698–717.

    Article  Google Scholar 

  • Mori, M., Jefferson, J. J., Hummel, M., & Garbe, D. S. (2008). CNTF: A putative link between dopamine D2 receptors and neurogenesis. The Journal of Neuroscience, 28(23), 5867–5869.

    Article  Google Scholar 

  • Parikh, V., Howe, W. M., Welchko, R. M., Naughton, S. X., D’Amore, D. E., Han, D. H., Deo, M., Turner, D. L., & Sarter, M. (2013). Diminished trkA receptor signaling reveals cholinergic-attentional vulnerability of aging. The European Journal of Neuroscience, 37(2), 278–293. doi:10.1111/ejn.12090. Epub 2012 Dec 11.

    Article  Google Scholar 

  • Pereira, D. S., de Queiroz, B. Z., Miranda, A. S., Rocha, N. P., Felício, D. C., Mateo, E. C., Favero, M., Coelho, F. M., Jesus-Moraleida, F., Gomes Pereira, D. A., Teixeira, A. L., & Máximo Pereira, L. S. (2013). Effects of physical exercise on plasma levels of brain-derived neurotrophic factor and depressive symptoms in elderly women – A randomized clinical trial. Archives of Physical Medicine and Rehabilitation, 94(8), 1443–1450.

    Article  Google Scholar 

  • Reichardt, L. F. (2006). Neurotrophin-regulated signalling pathways. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 361(1473), 1545–1564. Review.

    Article  Google Scholar 

  • Svendsen, C. N., Cooper, J. D., & Sofroniew, M. V. (1991). Trophic factor effects on septal cholinergic neurons. Annals of the New York Academy of Sciences, 640, 91–94.

    Article  Google Scholar 

  • Yaar, M., Zhai, S., Pilch, P. F., Doyle, S. M., Eisenhauer, P. B., Fine, R. E., & Gilchrest, B. A. (1997). Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer’s disease. The Journal of Clinical Investigation, 100(9), 2333–2340.

    Article  Google Scholar 

  • Yankner, B. A., Lu, T., & Loerch, P. (2008). The aging brain. Annual Review of Pathology, 3, 41–66.

    Article  Google Scholar 

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Authors and Affiliations

  1. Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190, Sala 281, 30130-100, Belo Horizonte, MG, Brazil

    Natália Pessoa Rocha & Antônio Lúcio Teixeira

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  1. Natália Pessoa Rocha
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  2. Antônio Lúcio Teixeira
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Correspondence to Natália Pessoa Rocha .

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Editors and Affiliations

  1. The University of Queensland, Brisbane, Queensland, Australia

    Nancy A. Pachana

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Rocha, N.P., Teixeira, A.L. (2016). Neurotrophic Factors in Aging. In: Pachana, N. (eds) Encyclopedia of Geropsychology. Springer, Singapore. https://doi.org/10.1007/978-981-287-080-3_263-1

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  • DOI: https://doi.org/10.1007/978-981-287-080-3_263-1

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  • Online ISBN: 978-981-287-080-3

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