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Z-DNA

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Handbook of Chemical Biology of Nucleic Acids

Abstract

Z-DNA, a left-handed form of double-stranded DNA formed by CG repeat sequences, was discovered more than 50 years ago. Since then, the presence of several Z-DNA-binding proteins and Z-DNA-forming sequences in the genome have confirmed the biological relevance of Z-DNA. Over the last five decades, enormous scientific achievements have been made by outstanding scientists to reveal the chemical nature of Z-DNA and the role of Z-DNA and Z-DNA-binding proteins in cells. In this chapter, various chemical biology approaches used to evaluate the physicochemical characteristics and biological roles of Z-DNA/Z-RNA and their binding proteins are comprehensively reviewed. Finally, the clinical implications and perspectives regarding Z-DNA are discussed.

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Acknowledgments

This work was supported by National Research Foundation of Korea (NRF) grants funded by the Ministry of Education, Science, and Technology (MSIT) of the Korean government (2020RC1C1C1007371 to D.K.; 2020R1A4A1018019 and 2021R1A2C3011644 to K.K.; 2020R1A2C1006909 and 2022R1A4A1021817 to J.-H.L).

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Author notes

  1. Doyoun Kim and Vinod Kumar Subramani contributed equally with all other contributors.

Authors and Affiliations

  1. Therapeutics and Biotechnology Department, Drug Discovery Platform Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon, Republic of Korea

    Doyoun Kim

  2. Medicinal Chemistry and Pharmacology, Korea University of Science and Technology (UST), Daejeon, Republic of Korea

    Doyoun Kim

  3. Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea

    Vinod Kumar Subramani & Kyeong Kyu Kim

  4. Immunology Frontier Research Center, Osaka University, Osaka, Japan

    Soyoung Park

  5. Department of Chemistry and RINS, Gyeongsang National University, Jinju, Republic of Korea

    Joon-Hwa Lee

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  1. Doyoun Kim
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  2. Vinod Kumar Subramani
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  3. Soyoung Park
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  4. Joon-Hwa Lee
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  5. Kyeong Kyu Kim
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Corresponding authors

Correspondence to Soyoung Park , Joon-Hwa Lee or Kyeong Kyu Kim .

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Editors and Affiliations

  1. Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, Kobe, Japan

    Naoki Sugimoto

Section Editor information

  1. Slovenian NMR Centre, National Institute of Chemistry, Ljubljana, Slovenia

    Janez Plavec

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Kim, D., Subramani, V.K., Park, S., Lee, JH., Kim, K.K. (2023). Z-DNA. In: Sugimoto, N. (eds) Handbook of Chemical Biology of Nucleic Acids. Springer, Singapore. https://doi.org/10.1007/978-981-19-9776-1_9

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