Abstract
In this chapter, biomaterial development based on DNA-sugar and DNA-peptide conjugates and DNA assemblies is highlighted. The conjugation of sugar chains to double-strand DNA conferred nuclease resistance and lectin recognition abilities on the DNA without affecting its transcription ability. On-off control of the transcription and translation of plasmid DNA was achieved by adding sugar chains to complexes of DNA-sugar conjugates and lectins. Novel glyco-clusters with regular intervals were developed by the self-assembly of sugar-conjugated oligodeoxyribonucleotides with half-sliding complementary DNAs. The lectin recognition ability of the sugar-conjugated DNA assembly was controlled by changing sugar arrangement using DNA as a molecular ruler. The self-assembly of β-annulus peptide conjugated with DNA at the C-terminal produced DNA-decorated artificial viral capsids, which could partially hybridize complementary polynucleotides to form aggregates. The N-terminal modification of β-annulus peptide with dT20 through a disulfide bond enabled encapsulating mRNA bearing a poly-A tail into the artificial viral capsid through hybridization. DNA three-way junctions bearing self-complementary sticky ends were self-assembled into nanometer-to-micrometer-sized “nucleo-spheres” based on concentration. The nucleo-spheres encapsulated anionic dyes into their interior with low polarity and released them according to duplex melting. The installation of photo-responsive and reduction-cleavable moieties enabled the disassembly of nucleo-spheres controlled by light and reducing agents. A spatiotemporal light-induced peptide nanofiber growth system was developed using conjugates comprising β-sheet-forming peptide and dA20, linked by a photocleavable amino acid. The modification of the conjugates on the nucleo-spheres enabled negative phototaxis of the nucleo-spheres due to the photo-induced asymmetric growth of peptide nanofibers on the surface.
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Matsuura, K., Inaba, H. (2022). Biomaterials Based on DNA Conjugates and Assemblies. In: Sugimoto, N. (eds) Handbook of Chemical Biology of Nucleic Acids. Springer, Singapore. https://doi.org/10.1007/978-981-16-1313-5_86-1
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