Abstract
Oxidative DNA modifications are a major challenge to genomic stability. One of the most abundant oxidative DNA base damage is the 8-oxoG, a mutagenic lesion that needs to be efficiently removed to avoid G/C to T/A transversions. It has recently been postulated that 8-oxoG could also act as an epigenetic mark. There is indeed increasing evidence for the key roles played by 8-oxoG and OGG1, the DNA glycosylase responsible for initiating its removal through the base excision repair (BER) pathway, in the regulation of transcription. While it seems clear that there should be a tight coordination between both processes to avoid collision between DNA repair and transcription machineries, there is a real need in the field to better conciliate both aspects that are essential for the maintenance and the expression of our genome. In this review, we will discuss the present knowledge concerning the role of OGG1 in both DNA repair and transcriptional regulation in order to shed light on the coordination between these two major cellular processes.
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Acknowledgments
We thank Bernd Epe and Juan Pablo Radicella for the critical reading of the manuscript and for fruitful discussions. We apologize to the authors of many excellent manuscripts that could not be cited during this review because of strong restrictions in the number of references. A.C. lab is funded by Agence National de la Recherche (project ANR TG-TOX), CEA Radiobiology program, Foncer contre le cancer, and Electricité de France.
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Di Guilmi, AM., Fonknechten, N., Campalans, A. (2023). OGG1 at the Crossroads Between Repair and Transcriptional Regulation. In: Sugimoto, N. (eds) Handbook of Chemical Biology of Nucleic Acids. Springer, Singapore. https://doi.org/10.1007/978-981-16-1313-5_50-1
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