Abstract
Transfer RNAs (tRNAs) are universal components of cells found in organisms from three domains of life. An important function of tRNAs in the cell is their involvement in the accurate translation of messenger RNA (mRNA) codons and the delivery of the corresponding amino acids to the ribosomal machinery during protein synthesis. Therefore, tRNAs are key players in the dynamic process of regulating cellular gene expression. This review focuses primarily on the specific epitranscriptome of bacterial tRNAs containing 2-thio- and 2-selenouridines in wobble position and describes recent achievements in understanding their biosynthetic pathways and their function in correct recognition of synonymous codons in mRNA.
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This review was prepared within the project funded by The National Science Center in Poland (projects UMO-2018/29/B/ST5/02509 to B.N. and UMO-2016/23/B/NZ1/02316 to M.S.).
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Nawrot, B., Sierant, M., Szczupak, P. (2023). Sulfur and Selenium modified bacterial tRNAs. In: Sugimoto, N. (eds) Handbook of Chemical Biology of Nucleic Acids. Springer, Singapore. https://doi.org/10.1007/978-981-16-1313-5_43-1
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